Author(s): Herin Setianingsih, Erina Yatmasari, M. Fathi Ilmawan


DOI: 10.52711/0974-360X.2023.00672   

Address: Herin Setianingsih*, Erina Yatmasari, M. Fathi Ilmawan
Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023

The rise and fall of the COVID-19 wave continue to be watched because the right antiviral drug has not yet been found. Remdesivir is an antiviral drug that is much sought after, especially when the number of COVID-19 cases is spreading worldwide. Until now, the US Food and Drug Administration (FDA) and the Drugs Controller General of India (DCGI) have confirmed the treatment for COVID-19 infection is remdesivir; because of that, remdesivir is very expensive and difficult to find, so that other similar or alternative drugs are needed. Even better ones with better potential too. Based on studies, insilico meridine and xestosaprol M have the same potential as remdesivir as an anti-COVID-19 virus.

Cite this article:
Herin Setianingsih, Erina Yatmasari, M. Fathi Ilmawan. Meridine and Xestosaprol M have Potential Anti-Virus Resembling Remdesivir. Research Journal of Pharmacy and Technology 2023; 16(9):4112-8. doi: 10.52711/0974-360X.2023.00672

Herin Setianingsih, Erina Yatmasari, M. Fathi Ilmawan. Meridine and Xestosaprol M have Potential Anti-Virus Resembling Remdesivir. Research Journal of Pharmacy and Technology 2023; 16(9):4112-8. doi: 10.52711/0974-360X.2023.00672   Available on:

1.    Ansori ANM, Kharisma VD, Fadholly A, Tacharina MR, Antonius Y, Parikesit AA. Severe Acute Respiratory Syndrome Coronavirus-2 Emergence and Its Treatment with Alternative Medicines: A Review. Research Journal of Pharmacy and Technology. 2021; 14(10):5551-7. doi: 10.52711/0974-360X.2021.00967
2.    Kharisma VD, Kharisma SD, Ansori ANM, Kurniawan HP, Witaningrum AM, Fadholly A, Tacharina MR. Antiretroviral Effect Simulation from Black Tea (Camellia sinensis) via Dual Inhibitors Mechanism in HIV-1 and its Social Perspective in Indonesia. Res J Pharm Technol. 2021; 14(1): 455-460. doi: 10.5958/0974-360X.2021.00083.4
3.    SoaresD, Nursalam, Carvalho JGde, Oqui M, Barros I, Silva Vda. Nursing care and the psychology effects on post-care nurses serving COVID-19 patients in Vera Cruz isolation room, Dili, Timor-Leste. Bali Medical Journal. 2022; 11(2): 905–909. DOI: 10.15562/bmj.v11i2.3411 More Citation Formats
4.    Hanardi DYP, Rochmawati E. Tracing management and epidemiological characteristics of close contact COVID-19 in primary health care. Bali Medical Journal. 2022; 11(3): 1614–1619. DOI: 10.15562/bmj.v11i3.3705
5.    Santosa D, Sofro MAU, Retnaningsih R, Pangarsa EA, Setiawan B, Farhanah N, Kholis FN, Handoyo T, Rahardjo S, Nindhita LR, Puspitasari I, Naibaho RM, Kharismasari R, Kartiyani L, Yunarvika V, Rizky D,Suhartono S.Convalescent plasma as an adjunctive treatment for severe and critically ill COVID-19. Bali Medical Journal. 2021; 10(3): 851–859. DOI: 10.15562/bmj.v10i3.2590
6.    Kadriyan H, PrasedyaES, Pieter NAL, Gaffar M, PunagiAQ, BukhariA. The potential role of exosome on cytokine storm and treatment of severe COVID-19 infection. Bali Medical Journal. 2020; 9(3): 630–636. DOI: 10.15562/bmj.v9i3.1966
7.    Setianingsih H, Yatmasari E, Ilmawan MF, Zahroh H & Lestari EDP. Targeting multiple SARS-Cov-2 and human proteins: in silico approach for COVID-19 drug repurposing. International Journal of Pharmaceutical Research. 2020;12(2):3184–3192. doi: 10.31838/ijpr/2020.12.02.427
8.    Sijbesma E, Hallenbeck KK, Leysen S, de Vink PJ, Skóra L, Jahnke W, Brunsveld L, Arkin MR and Ottmann C. Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers. Journal of the American Chemical Society. 2019;141(8):3524–3531. doi: 10.1021/jacs.8b11658
9.    Fadholly A, Ansori ANM, Kharisma VD, Rahmahani J, Tacharina MR. Immunobioinformatics of Rabies Virus in Various Countries of Asia: Glycoprotein Gene. Res J Pharm Technol. 2021; 14(2): 883-886. doi: 10.5958/0974-360X.2021.00157.8
10.    Ansori ANM, Fadholly A, Proboningrat A, Hayaza S, Susilo RJK, Naw SW, Posa GAV, Yusrizal YF, Sibero MT, Sucipto TH, Soegijanto S. In vitro antiviral activity of Pinus merkusii (Pinaceae) stem bark and cone against dengue virus type-2 (DENV-2). Res J Pharm Technol. 2021; 14(7):3705-8. doi: 10.52711/0974-360X.2021.00641
11.    Proboningrat A, Kharisma VD, Ansori ANM, Rahmawati R, Fadholly A, Posa GAV, Sudjarwo SA, Rantam FA, Achmad AB. In silico Study of Natural inhibitors for Human papillomavirus-18 E6 protein. Res J Pharm Technol. 2022; 15(3):1251-6. doi: 10.52711/0974-360X.2022.00209
12.    Kharisma VD, Ansori ANM, Jakhmola V, Rizky WC, Widyananda MH, Probojati RT, Murtadlo AAA, Rebezov M, Scherbakov P, Burkov P, Matrosova Y, Romanov A, Sihombing MAEM, Antonius Y, Zainul R. Multi-strain human papillomavirus (HPV) vaccine innovation via computational study: A mini review. Res J Pharm Technol. 2022; 15(8).
13.    Pires DEV, Blundell TL and Ascher DB. pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. Journal of Medicinal Chemistry. 2015;58(9):4066–4072. doi: 10.1021/acs.jmedchem.5b00104
14.    Sulaiman M, Nissapatorn V, Rahmatullah M, Paul AK, Rajagopal M, Rusdi NA, Seelan JSS, Suleiman M, Zakaria ZA, Wiart C. Antimicrobial Secondary Metabolites from the Mangrove Plants of Asia and the Pacific. Mar Drugs. 2022; 20(10):643. doi: 10.3390/md20100643.
15.    Gaurav A, Agrawal N, Al-Nema M, Gautam V. Computational Approaches in the Discovery and Development of Therapeutic and Prophylactic Agents for Viral Diseases. Curr Top Med Chem. 2022;22(26):2190-2206. doi: 10.2174/1568026623666221019110334.
16.    Zhao RZ, Yuan D, Liu SJ, Chen YJ, Liu LJ and Zhao Y. Liver targeting effect of vinegar-baked Radix Bupleuri on rhein in rats. Journal of Ethnopharmacology. 2010; 132(2):421–428. doi: 10.1016/j.jep.2010.08.021
17.    Chia LY, Kumar PV, Maki MAA, Ravichandran G, Thilagar S. A Review: The Antiviral Activity of Cyclic Peptides. Int J Pept Res Ther. 2023; 29(1): 7. doi: 10.1007/s10989-022-10478-y.
18.    Fadholly A, Ansori ANM, Utomo B. Anticancer Effect of Naringin on Human Colon Cancer (WiDr Cells): In Vitro Study. Research Journal of Pharmacy and Technology. 2022; 15(2): 885-888. DOI: 10.52711/0974-360X.2022.00148
19.    McCarthy PJ, Pitts TP, Gunawardana GP, Kelly-Borges M & Pomponi SA. Antifungal activity of meridine, a natural product from the marine sponge Corticium sp. Journal of Natural Products. 1992;55(11):1664–1668. doi: 10.1021/np50089a016
20.    Ahadini PA, Reihan AI, Utama MBW, Khaerunnisa S, Fadilah F. In-Silico Study: Potential Inhibitor of Cyclin-Dependent Kinase 6 (CDK6) from Natural Plant Compounds for Melanoma Treatment. JUXTA. 2022; 13(2): 93-99. DOI: 10.20473/juxta.V13I22022.93-99

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available