Author(s): Kopparesh Rao Deshpande, Subhashree Ray, Swarup Kumar Panda, Sudeshna Behera, Subrat Kumar Tripathy, Samir Sahu

Email(s): subhashreeray@soa.ac.in

DOI: 10.52711/0974-360X.2023.00666   

Address: Kopparesh Rao Deshpande1, Subhashree Ray2*, Swarup Kumar Panda2, Sudeshna Behera2, Subrat Kumar Tripathy2, Samir Sahu3
1Sri Sai College of Dental Surgery, Kothrepally, Opposite to Shiv Sagar Lake, Vikarabad, Telangana - 501102, India.
2Department of Biochemistry, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Sector - 8, Kalinga Nagar, Ghatikia, Bhubaneswar - 751003, India.
3Department of Medicine, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Sector - 8, Kalinga Nagar, Ghatikia, Bhubaneswar - 751003, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
Oral submucous fibrosis is a type of chronic oral pathological ailment, which is having insidious onset. It possesses high rate of malignant transformation, which gets accentuated by pernicious oral habits like chewing of areca nut in betel. OSMF predisposes to marked hematological abnormalities, leading to anemia and reduction in levels of serum iron and proteins. The aim of this study was to measure the hemoglobin, serum iron and protein levels among OSMF patients and also to compare these parameters with healthy controls.In the hospital-based study, among 100 study subjects, 45 OSMF patients were selected as cases, whereas 55 apparently healthy individuals were chosen as controls. The hemoglobin, serum iron and protein levels were estimated using hematological and biochemical autoanalyzers. Significantly lower levels of hemoglobin, serum iron, and protein levels were observed in OSMF patients in comparison with apparently healthy subjects.Findings of this study focus on the necessity and rationale of assessing hemoglobin, serum iron and protein amongst OSMF patients. These biochemical assessments in the precancerous condition of OSMF may help in early diagnosis and prognosis. Besides that, iron therapy should be initiated at the earliest with the initial diagnosis, which can be helpful to check further deterioration of the aforesaid premalignant condition. Further extensive studies are required for fine delineation of hematological alterations in OSMF patients.


Cite this article:
Kopparesh Rao Deshpande, Subhashree Ray, Swarup Kumar Panda, Sudeshna Behera, Subrat Kumar Tripathy, Samir Sahu. Evaluation of Iron Deficiency in OSMF patients: A Cross-sectional Study. Research Journal of Pharmacy and Technology 2023; 16(9):4065-9. doi: 10.52711/0974-360X.2023.00666

Cite(Electronic):
Kopparesh Rao Deshpande, Subhashree Ray, Swarup Kumar Panda, Sudeshna Behera, Subrat Kumar Tripathy, Samir Sahu. Evaluation of Iron Deficiency in OSMF patients: A Cross-sectional Study. Research Journal of Pharmacy and Technology 2023; 16(9):4065-9. doi: 10.52711/0974-360X.2023.00666   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-9-10


REFERENCES:
1.    V. Padmaharish. Salivary Biomarkers of Oral Cancer – A Review. Research J. Pharm. and Tech. 2016; 9(7):1007-1012. doi: 10.5958/0974-360X.2016.00190.6
2.    Swain SK, Kar D. Vocal fold leukoplakia–An underestimated premalignant lesion of the larynx: A narrative review. Cancer Research, Statistics, and Treatment. 2021;4(2):321-327.
3.    Lakshman Sivakumar Vijay, J. Ravi Sankar. Fuzzy Logic Approach for The Simultaneous Analysis of trends in oral Cancer Victims. Research J. Pharm. and Tech. 2019; 12(8):3825-3828 doi: 10.5958/0974-360X.2019.00655.3
4.    Antioxidants and Oral Cancer - A Review. Research J. Pharm. and Tech. 2016; 9(8):1287-1290. doi: 10.5958/0974-360X.2016.00244.4
5.    Khanna SS, Karjodkar FR. Circulating immune complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer: A randomized, controlled clinical trial. Head and Face Medicine. 2006;2(33):1-10.
6.    Rajalalitha P, Vali S. Molecular pathogenesis of oral submucous fibrosis: A collagen metabolic disorder. J Oral Pathol Med. 2005;34:321-8.
7.    KayalviliSanmugam. A Study of Lipid Profile Levels in Oral Cancer. Research J. Pharm. and Tech. 2015; 8(9): 1259-1263. doi: 10.5958/0974-360X.2015.00228.0
8.    Nandakumar. E, G. Savitha. A study of Salivary Lactate Dehydragenase (LDH) level in normal individuals and the Oral Cancer Patients. Research J. Pharm. and Tech. 2015; 8(7): 932-934. doi: 10.5958/0974-360X.2015.00155.9
9.    Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: Review on aetiology and pathogenesis. Oral Oncol. 2006;42:561-8.
10.    Chiu CJ, Chang ML, Chiang CP, Hahn LJ, Hsieh LL, Chen CJ. Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. Cancer Epidemiol Biomarkers Prev. 2002;11:646-53.
11.    Murti PR, Bhonsle RB, Pindborg JJ, Daftary DK, Gupta PC, Mehta FS. Malignant transformation rate in oral submucous fibrosis over a 17-year period. Community Dent Oral Epidemiol1. 985; 13:340-41.
12.    Modi MA, Dave VR, Prajapa VG, Mehta KA. A clinical profile of oral submucous fibrosis. NJIRM. 2012; 3:152‑5.
13.    More CB, Gupta S, Joshi J, Varma SN. Classification system for oral submucous fibrosis. J Indian Acad Oral Med Radiol. 2012;24:24‑9.
14.    S. Senthilkumar, S. Tarun. A Study on Effectiveness of Therabite Exercises to improve the Jaw Range of Motion in Trismus among Oral Cancer Patients. Research J. Pharm. and Tech. 2020; 13(2): 519-522. doi: 10.5958/0974-360X.2020.00098.0
15.    Nauma Hafeez. Creatine phosphokinase levels in Oral cancer Patients. Research J. Pharm. and Tech. 2016; 9(10):1577-1580. doi: 10.5958/0974-360X.2016.00310.3
16.    Lakshman Sivakumar Vijay, J. Ravi Sankar. Fuzzy Logic Approach for The Simultaneous Analysis of trends in oral Cancer Victims. Research J. Pharm. and Tech. 2019; 12(8):3825-3828 doi: 10.5958/0974-360X.2019.00655.3
17.    Gupta MK, Mhaske S, Ragavendra R, Imtiyaz. Oral submucous fibrosis – Current concepts in etiopathogenesis. Peoples J Sci Res. 2008;1:39‑44.
18.    Savita JK, Girish HC, Murgod S, Kumar H. Oral submucous fibrosis – A review (part 2). J Health Sci Res. 2011;2:37‑48.
19.    Pandya S, Chaudhary AK, Singh M, Singh M, Mehrotra R. Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis. Head Neck Oncol. 2009;1:10.
20.    V. Papadopol, O. Damian, I. Palamaru, C. Adam, N. lorescu, and D. Dam˘ aceanu. Maternal biomineral status and newborn data. The Journal of Preventive Medicine. 2002; 10(1): 41– 46.
21.    P. V. Angadi and S. S. Rao. Areca nut in pathogenesis of oral submucous fibrosis: revisited.  Oral and Maxillofacial Surgery.  2011; 10(1–9).
22.    K. Ranganathan, M. U. Devi, E. Joshua, K. Kirankumar, and T. R. Saraswathi. Oral submucous fibrosis: a case-control study in Chennai, South India. Journal of Oral Pathology and Medicine.  2004; 33(5); 274–277, 2004.
23.    C. W. Van Wyk, H. A. Seedat, and V. M. Phillips.  Collagen in submucous fibrosis: an electron-microscopic study. Journal of Oral Pathology and Medicine. 1990; 19(4): 182–187.
24.    D. K. Paissat. Oral submucous fibrosis. International Journal of Oral Surgery. 1981; 10(5): 307–312.
25.    Chandran V, Anitha M, Avinash SS, Rao GM, Shetty BV, Sudha K. Protein oxidation: A potential cause of hypoalbuminemia in oral cancer. Biomedical Research. 2012; 23(2):227-30.
26.    Nayyar AS, Khan M, Vijayalaxmi KR, Suman B, Gayitri HC, Anitha M. Serum total protein, albumin and advanced oxidation protein products – Implications in oral squamous cell carcinoma. Malaysian J Pathol. 2012; 34(1): 47-52.
27.    Singh P, Gharote H, Nair P, Hegde K, Saawarn N, Guruprasad R. Evaluation of cachexia in oral submucous fibrosis. J Indian Aca Oral Med Radiol. 2012; 24(2):130-32.
28.    Felix, J. Ravi Sankar, G. Mokesh Rayalu. Fuzzy Associative Memories Approach to Analyze the Oral Cancer. Research J. Pharm. and Tech. 2018; 11(2):523-526. doi: 10.5958/0974-360X.2018.00097.5
29.    Rath S, Das M, Kar D, Bhuyan R. Computational Genomic Analysis of Oral Squamous Cell Carcinoma - A New Diagnostic Approach. Int J Cur Res Rev. Research on Emerging Diseases in the Indian Context: Clinico-Pathological and Technical Aspects. 2021: 85-90, http://dx.doi.org/10.31782/IJCRR.2021.SP247
30.    C. D. Anuradha and C. S. Devi. Serum protein, ascorbic acid and iron and tissue collagen in oral submucous fibrosis—a preliminary study,” The Indian Journal of Medical Research. 1993;  98: 147–151.
31.    R.Maher, P. Aga, N.W. Johnson, R. Sankaranarayanan, and S.Warnakulasuriya .Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan. Nutrition and Cancer. 1997; 27(1): 41–47.  
32.    S. K. Katharia, S. P. Singh, and V. K. Kulshreshtha, “The effects of placenta extract in management of oral submucous fibrosis,” Indian Journal of Pharmacology. 1992; 24: 181–183.
33.    M. Ahmad, S. Ali, A. Ali, and K. Chaubey. Epidemiological and etiological study of oral submucous fibrosis among gutkha chewers of Patna, Bihar, India.  Journal of Indian Society of Pedodontics and Preventive Dentistry. 2006; 24(2): 84–89.
34.    S. Meghji, A. Scutt, J. P. Canniff, W. Harvey, and J. D. Phillipson. Inhibition of collagenase activity by areca nut tannins:a mechanism of collagen accumulation in oral submucous fibrosis? Journal of Dental Research. 1982;  61: 545.
35.    Moos KS, Madan DK. Oral Submucous Fibrosis. Br Dent J. 1968; 124: 313-317.
36.    Ranganathan K, Gauri M. An overview of classification schemes for oral submucous fibrosis. J Oral Pathol Med. 2006; 10:55-58.
37.    R. Rajendran. Oral submucous fibrosis. Journal of Oral and Maxillofacial Pathology. 2003;7: 1–4.
38.    Rajendran R, Vasudevan DM, Vijayakumar T. Serum levels of iron and proteins in oral submucous fibrosis (OSMF). Ann Dent. 1990;49(2):23-25.
39.    Balpande AR, Sathawane RS. Estimation and comparative evaluation of serum iron, copper, zinc and copper/ zinc ratio in oral leukoplakia, submucous fibrosis and squamous cell carcinoma. Journal of Indian Academy of Oral Medicine and Radiology. 2010; 22(2): 73-76.
40.    Ganapathy KS, Gurudath S, Balikai B, Ballal S, Sujatha D. Role of iron deficiency in oral submucous fibrosis: An initiating or accelerating factor. Journal of Indian Academy of Oral Medicine and Radiology. 2011; 23(1): 25-28.
41.    Rupak S, Baby GG, Padiyath S, Kiran Kumar KR. Oral submucous fibrosis and iron deficiency anaemia relationship revisited- Results from an Indian study. E-Journal of Dentistry. 2012; 2(2): 159-65.
42.    Taneja L, Anjana B, Vaishali K. Haemoglobin levels in patients with oral submucous fibrosis. Journal of Indian Academy of Oral Medicine and Radiology. 2007;19:329-33.
43.    Karthik H, Nair P, Gharote HP, Aggarwal K, Bhatt GR, Rajaram DK. Role of haemoglobin and serum iron in oral submucous fibrosis: A clinical study. Scientific World Journal. 2012; 2012: 254013.
44.    Tadakamadla J, Kumar S, Mamatha GP. Evaluation of serum copper and iron levels among oral submucous fibrosis patients. Med Oral Patol Oral Cir Bucal. 2011; 16(7):870-73.
45.    P. K. Kakar, R. K. Puri, and V. P. Venkatachalam. Oral submucous fibrosis—treatment with hyalase. Journal of Laryngology and Otology. 1985; 99(1): 57–59.
46.    C. Trivedy, K. A. A. S. Warnakulasuriya, V. K. Hazarey, M. Tavassoli, P. Sommer, and N. W. Johnson. The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma. Journal of Oral Pathology and Medicine. 1999; 28(6): 246–251.
47.    Chandran V, Anitha M, Avinash SS, Rao GM, Shetty BV, Sudha K. Protein oxidation: A potential cause of hypoalbuminemia in oral cancer. Biomedical research. 2012;23(2):227-30.
48.    Nayyar AS, Khan M, Vijayalaxmi KR, Suman B, Gayitri HC, Anitha M. Serum total protein, albumin and advanced oxidation protein products – Implications in oral squamous cell carcinoma. Malaysian J Pathol. 2012; 34(1): 47-52.
49.    Patidar KA, Parwani RN, Wanjari SP. Correlation of salivary and serum IgG, IgA levels with oral protein in oral submucous fibrosis. J Oral Sci. 2011; 53: 97-102.
50.    Dawood RM, Hasan HR. Assessment of salivary and serum proteins in patients with oral tumours. Baghdad Science Journal. 2013; 10(3): 934-43.

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