Author(s):
Kamal, Deepika, Neha, Ritu, Shubham
Email(s):
kamal@kuk.ac.in , nehamph2015@kuk.ac.in , ritumph2018@kuk.ac.in , shubhammph2010@kuk.ac.in
DOI:
10.52711/0974-360X.2023.00654 
Address:
Dr. Kamal, Deepika, Neha*, Ritu, Shubham
Institute of Pharmaceutical Science, Kurukshetra University, Kurukshetra (Haryana-136119).
*Corresponding Author
Published In:
Volume - 16,
Issue - 8,
Year - 2023
ABSTRACT:
The new medication delivery technology relies heavily on mucoadhesive microspheres. Certain medication delivery issues can be solved by offering a regulated drug delivery system that boosts a drug's therapeutic efficacy. One option is to use mucoadhesive microspheres as a support system for medication administration, which can be done in a range of techniques. Mucoadhesive microsphere stays at the application or absorption site for a long time. It aids to improve and boost the therapeutic effectiveness of medications by facilitating direct contact with the underlying absorbent surface beneath. It is an excellent navigation system with a excessive level of safety. Microspheres are transporter-connected medication drug delivery architecture with a centre of medication and totally exterior layers of polymer as a covering material, with molecular sizes ranging from 1-1000 micrometer in breadth.
Cite this article:
Kamal, Deepika, Neha, Ritu, Shubham. Mucoadhesive microspheres: An innovative approach to enhance Gastro-retention. Research Journal of Pharmacy and Technology. 2023; 16(8):3983-9. doi: 10.52711/0974-360X.2023.00654
Cite(Electronic):
Kamal, Deepika, Neha, Ritu, Shubham. Mucoadhesive microspheres: An innovative approach to enhance Gastro-retention. Research Journal of Pharmacy and Technology. 2023; 16(8):3983-9. doi: 10.52711/0974-360X.2023.00654 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-8-74
REFERENCES:
1. Mayavanshi AV. Gajjar SS. Floating drug delivery systems to increase gastric retention of drugs: A Review. Research J. Pharm. and Tech. 2008; 1(4): 345-348,
2. Mahajan Sakshi, Mandloi Rampal, Birla Nikhlesh, Pillai Sujit. A Review on Mucosal Drug Delivery System. Res. J. Pharmacognosy and Phytochem. 2019; 11(4):251-257. doi: 10.5958/0975-4385.2019.00042.6.
3. Rahaman ST. Mukherjee J. A review on mucoadhesive microspheres as an efficient drug delivery system. Indo American Journal of Pharmaceutical Research. 2020; 10(01), 573-579. doi:10.5281/zenodo.3632437 or 2231-6876.
4. Bansal H. Kaur SP. Gupta AK. Microspheres: Methods of preparation and applications: A comparative study. Int J Pharm Sci Rev Res. 2011; 10(1): 69 Available online at www.globalresearchonline.net;0976 – 044X.
5. Gholap SB. Banarjee SK. Gaikwad DD. Jadhav SL. Thorat RM. Hollow microsphere: A review. International Journal of Pharmaceutical Sciences Review and Research. 2010; 1(1): 74-9. Available online at www.globalresearchonline.net.
6. Choudhury A. Deka D . Sonowal K. Laskar RE. Microsphere: a promising approach for drug delivery. Journal of Applied Pharmaceutical Research. 2019;7(2):01-6.8 doi : https://doi.org/10.18231/j.joapr.2019.001.
7. Sahil K. Akanksha M. Premjeet S .Bilandi A .Kapoor B. Microsphere: A review. Int. J. Res. Pharm. Chem. 2011; 1(4):1184-98. Corpus ID: 16035491.
8. Chowdary KP. Rao YS. Mucoadhesive microspheres for controlled drug delivery. Biological and Pharmaceutical Bulletin. 2004; 27(11):1717-24. doi: https://doi.org/10.1248/bpb.27.1717.
9. Ratnaparkhi M. Wattamwar M. Jadhav A. Chaudhari S. Mucoadhesive microsphere review. Drug Dev. and Res. 2014 Apr; 6(2):10-19. Int. J. 0975-9344.
10. Alai M.S. Shinkar D.M. Saudagar R.B. A Review on Floating Mucoadhesive Drug Delivery System. Research J. Pharm. and Tech. 2017; 10(10):3567-3572. doi: https://doi.org/10.5958/0974-360X.2017.00646.1.
11. Mohammed M Husain. Nappinai M. Development and Method Validation of an Unconventional In-Vitro Test To Measure Mucoadhesive Strength of Tablets. Research J. Pharm. and Tech. 2009; 2 (2): 363-365.
12. Raj H. Sharma A. Sharma S. Verma KK. Chaudhari A. Mucoadhesive Microspheres: A Targeted Drug Delivery System. 2021 Apr 15; (2-S):150-5.Journal of Drug Delivery and Therapeutics.doi: https://doi.org/10.22270/jddt.v11i2-S.4791.
13. Albrecht K. Zirm EJ .Palmberger TF. Schlocker W. Bernkop-Schnürch A. Preparation of thiomer micro particles and in vitro evaluation of Parameters influencing their mucoadhesive properties. 2006 Jan 1; 32(10):1149-57. Drug development and industrial pharmacy. doi: https://doi.org/10.1080/03639040600712334.
14. Punitha S .Girish Y. Polymers in mucoadhesive buccal drug delivery system: A review. Int J Res Pharm Sci. 2010; 1(2):170-86. Available online on :https://ijrps.com/index.php/home/search or 0975-7538.
15. Alagusundaram M. Chetty MS .Umashankari K .Badarinath AV. Lavanya C. Ramkanth S. Microspheres as a novel drug delivery system-a review. Int J Chem Tech Res. 2009 ;1(3):526-34.
16. MHG Dehghan. Baby H Dandge .Varsha M Gaikwad. Sachin Jagdale. Bioadhesive Drug Delivery Systems - Background, Applications and Trends. Research J. Pharm. and Tech. 2010; 3(1): 234-238.
17. Kumari N. Aggarwal G. Harikumar SL. Mucoadhesive microspheres: A review. Journal of Drug Delivery and Therapeutics. 2014; 4(5): 48-54. doi: https://doi.org/10.22270/jddt.v4i5.953.
18. Radha GV. Samantha L. Swetha Y. Praveen K. Formulation and in vitro evaluation of mucoadhesive microspheres of nifedipine. Journal of Pharmaceutical and Scientific Innovation. 2012; 1(5): 39-43. Available on: http://www.jpsionline.com/; 2277-4572.
19. Yadav VK. Kumar B. Prajapati SK. Shafaat K. Design and evaluation of mucoadhesive microspheres of repaglinide for oral controlled release. International Journal of Drug Delivery. 2011; 3(2):357. doi :http://dx.doi.org/10.5138/ijdd.v3i2.232.
20. Nagahara N. Akiyama Y. Nakao M . Tada M .Kitano M .Ogawa Y. Mucoadhesive microspheres containing amoxicillin for clearance of Helicobacter pylori. Antimicrobial agents and chemotherapy. 1998; 42(10): 2492-4. doi: https://doi.org/10.1128/AAC.42.10.2492.
21. Nagpal Navneet. Arora Manisha.Rahar Sandeep. Swami Gaurav. Sharma Dinesh. Kapoor Reni . Mucoadhesion Based Solid Dosage Form: The Next Generation. Research J. Pharma. Dosage Forms and Tech. 2010;2(5): 323-328. https://rjpdft.com/AbstractView.aspx?PID=2010-2-5-2 .
22. Parmar HK . Pandya KK. Pardasani LJ. Panchal VS. Tandel T. A systematic review on mucoadhesive drug delivery system. World J Pharm Res. 2017; 6(9): 337-66. doi: 10.20959/wjpr20179-9281.
23. Asane GS. Nirmal SA .Rasal KB. Naik AA. Mahadik MS. Rao YM. Polymers for mucoadhesive drug delivery system: a current status. Drug Development and Industrial Pharmacy. 2008; 34(11): 1246-66. doi : https://doi.org/10.1080/03639040802026012.
24. Grabovac V. Guggi D. Bernkop-Schnürch A . Comparison of the mucoadhesive properties of various polymers. Advanced Drug Delivery Reviews. 2005; 57(11):1713-23. doi : https://doi.org/10.1016/j.addr.2005.07.006.
25. Gyanesh Sahu. Harish Sharma. Chanchal Deep Kaur. A Novel Approach of Magnetic Modulated Microspheres. Asian J. Pharm. Res. 2013; 3(4): 220-224.
26. Reddy PC, Chaitanya KS. Rao YM. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. DARU Journal of Pharmaceutical Sciences. 2011; 19(6):385–403.
27. Saraswathi B. Balaji A. Umashankar MS. Polymers in mucoadhesive drug delivery system-latest updates. Int J Pharm Sci. 2013; 5:423-30.
28. Bernkop-Schnürch A. Thiomers : a new generation of mucoadhesive polymers. Advanced drug delivery reviews. 2005; 57(11): 1569-82. doi : http://dx.doi.org/10.1016/j.addr.2005.07.002.
29. Prajapati SK. Tripathi P. Ubaidulla U. Anand V. Design and development of gliclazide mucoadhesive microcapsules: in vitro and in vivo Evaluation. AAPS Pharmscitech. 2008; 9(1): 224-30. doi: http://dx.doi.org/10.1208/s12249-008-9041-0.
30. Sachan NK. Pushkar S. Jha A, Bhattcharya A. Sodium alginate: the wonder polymer for controlled drug delivery. J Pharm Res. 2009 ; 2(8):1191-9.
31. Parenteau-Bareil R, Gauvin R, Berthod F. Collagen-based biomaterials for tissue engineering applications. Materials. 2010; 3(3): 1863-87. doi: https://doi.org/10.3390/ma3031863.
32. Kaurav H, Harikumar SL, Kaur A. Mucoadhesive microspheres as carriers in drug delivery: a review. International Journal of Drug Development and Research. 2012;4(2): 21-34. Available online http://www.ijddr.in or ISSN 0975-9344.
33. Roy S. Pal K. Anis A. Pramanik K. Prabhakar B. Polymers in mucoadhesive drug delivery systems: A brief note. Designed Monomers and Polymers. 2009; 12(6): 483-95. doi : https://doi.org/10.1163/138577209X12478283327236.
34. Prasad BS.Gupta VR. Devanna N. Jayasurya K. Microspheres as drug delivery system-a review. J Glob Trends Pharm Sci. 2014; 5: 1961-72. 2230-7346.
35. Namdev A. Issarani R. Khinchi MP. Microsphere as a novel drug delivery system: A review. Asian Journal of Pharmaceutical Research and Development. 2015:15-24.; http://www.ajprd.com/index.php/journal/index;2320-4850.
36. Virmani T. Gupta J. Pharmaceutical application of microspheres: An approach for the treatment of various diseases. Int J Pharm Sci Res. 2017; 8(8): 3253-60. doi: http://dx.doi.org/10.13040/IJPSR.0975-8232.
37. Sharma M. Dev SK. Kumar M. Shukla AK. Microspheres as suitable drug carrier in sustained release drug delivery: an overview. Asian Journal of Pharmacy and Pharmacology. 2018; 4(2):102-8. doi: http://dx.doi.org/10.31024/ajpp.2018.4.2.2.
38. Garg A. Upadhyay P. Mucoadhesive microspheres: A short review. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5(3):24-7. 0974-2441.
39. Sharma S. Barman M. Singh N. Bhardwaj A, Mishra R, Singh MC, Saxena PK. A Review on Mucoadhesive Microspheres as an Optimised Targeted Drug Delivery System. Indian Journal of Pharmaceutical and Biological Research. 2018; 6(04):01-4. doi :https://doi.org/10.30750/ijpbr.6.4.1.
40. AA. Shirwaikar A. Lakshmana Prabu S. Shirwaikar Kumari A. Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. ARS Pharmaceutica. 2009; 50(2): 51-62. 0004-2927.
41. Ramteke KH. Jadhav VB. Dhole SN. Microspheres: as carriers used for novel drug delivery system. IOSRPHR. 2012; 2(4): 44-8. doi:http://dx.doi.org/10.9790/3013-24204448.
42. Jayaprakash S. Halith SM. Firthouse PM. Kulaturanpillai K. Abhijith A. Nagarajan M. Preparation and evaluation of biodegradable microspheres of methotrexate. Asian Journal of Pharmaceutics. 2014; 3(1) doi : http://dx.doi.org/10.4103/0973-8398.49171.
43. Shital S. Shinde. Girishchandra R. Mandake. Manoj M.Nitalikar. Spray Drying: A Promising Technique to Enhance Solubility. Asian J Pharm. Tech. 2018; 8(4):255-260. doi: 10.5958/2231-5713.2018.00039.9.
44. Peppas NA. Buri PA. Surface Interfacial and molecular aspects of polymer Bioadhesion on soft tissues. Journal of Controlled Release. 1985. doi: https://doi.org/10.1016/0168-3659(85)90050-1
45. Vyas TK, Babbar AK. Sharma RK. Singh S. Misra A. Intranasal mucoadhesive micro emulsions of clonazepam : preliminary studies on brain targeting. Journal of Pharmaceutical Sciences. 2006; 95(3):570-80. doi: 10.1002/jps.20480 .
46. Bogataj M. Vovk T. Kerec M. Dimnik A. Grabnar I. Mrhar A. The correlation between zeta potential and mucoadhesion strength on pig vesical mucosa. Biological and Pharmaceutical Bulletin. 2003; 26(5):743-6. doi : https://doi.org/10.1248/bpb.26.743.
47. Rajput GC. Majmudar FD. Patel JK, Patel KN, Thakor RS, Patel BP, Rajgor NB. Stomach specific mucoadhesive tablets as controlled drug delivery system–A review work. Int J Pharm Biol Res. 2010; 1(1):30-41. doi : 10.4103/0975-8453.59515.
48. Meena KP, Dangi JS, Samal PK, Namedo KP. Recent advances in microsphere manufacturing technology. International Journal of Pharmacy and Technology. 2011; 3(1):854-5.; 0995-766X
49. Shaji J. Poddar A. Iyer S. Brain-targeted nasal clonazepam microspheres. Indian Journal of pharmaceutical Sciences. 2009; 71(6):715. PMCID: PMC2846487.
50. Murtaza G. Ahamd M. Akhtar N. Rasool F. A comparative study of various microencapsulation techniques: Effect of polymer viscosity on microcapsule characteristics. Pak. J. Pharm. Sci. 2009; 22(3):291-300. Corpus ID:3901741.
51. Soni ML. Kumar M. Namdeo KP. Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation. International Journal of Drug Delivery. 2010; 2(1). http://dx.doi.org/10.5138/ijdd.2010.0975.0215.02013.
52. Kaurav H. Hari Kumar SL. Kaur A. Mucoadhesive microspheres as carriers in drug delivery: a review. International Journal of Drug Development and Research. 2012; 4(2): 21-34.
53. D. Ashwini, Gayathri Mahalingam. Green Synthesized Metal Nanoparticles, Characterization and its Antidiabetic activities - A Review. Research J. Pharm. and Tech. 2020; 13(1): 468-474. doi: 10.5958/0974-360X.2020.00091.8
54. Jagdish K Arun, Dharmajit Pattanayak, B. Shrivastava, Ramesh Adepu. A Systemic review on Floating Mucoadhesive drug Delivery system and its Present Scenario. Research J. Pharm. and Tech 2020; 13(9):4509-4516. doi: 10.5958/0974-360X.2020.00795.7
55. Basini Nikunja Pati, Patel Jitendra, Qureshi Md Shamim, Kumar G.S. Preparation of Double Coated Multiparticulate Delivery System for an Anti-ulcerative Drug. Research J. Pharma. Dosage Forms and Tech. 2010; 2(5): 335-339
56. Nanne Chandrakanth, T.S. Ashwinkumr, G. Velrajan, , Balasubramaniam. Formulation and Evaluation of Bio-adhesive Buccal Drug Delivery of Esomeprazole Magnesium Tablets. Research J. Pharm. and Tech. 2013; 6(2): 220-224.