Author(s):
Bayyinatul Muchtaromah, Eko Budi Minarno, Rahmi Annisa, Arif Nur Muhammad Ansori, Ely Nuril Fajriyah, Prilya Dewi Fitriasari, Listiani Suhargo, Kenji Mishima
Email(s):
bayyinatul@bio.uin-malang.ac.id
DOI:
10.52711/0974-360X.2023.00635 
Address:
Bayyinatul Muchtaromah1*, Eko Budi Minarno1, Rahmi Annisa2, Arif Nur Muhammad Ansori3,4, Ely Nuril Fajriyah1, Prilya Dewi Fitriasari1, Listiani Suhargo5, Kenji Mishima6
1Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim, Malang, Indonesia.
2Department of Pharmacy, Faculty of Medical and Health Sciences, State Islamic University of Maulana Malik Ibrahim, Malang, Indonesia.
3Professor Nidom Foundation, Surabaya, Indonesia.
4Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
5Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
6Faculty of Chemical Engineering, Fukuoka University, Japan.
*Corresponding Author
Published In:
Volume - 16,
Issue - 8,
Year - 2023
ABSTRACT:
Nanoparticles from natural polymer materials chitosan are widely applied in drug delivery systems because of their unique properties, such as biocompatible, biodegradable, mucoadhesive, and increased permeation. This study aimed to synthesize chitosan nanoparticles Centella asiatica. The method used is ionic gelation using the crosslinker polyanion tripolyphosphate (TPP) with a difference in sonification time: 90, 120, 150 minutes. The difference in sonification to obtain the preparation conditions that can produce particles under 200nm with a good level of dispersion and stability, a study on the effect of sonification time on chitosan nanoparticles physical characteristics is performed. The PSA analysis result showed that the average particle size of C.asiatica extracts at 90, 120, 150 minutes sonication was 286.2nm, 269.2nm, 299.1nm. The results of the examination using FTIR showed that the C. asiatica extract had N-H and P = O groups, which meant that the ammonium ion had interaction of chitosan with the polyanion of TPP and C. asiatica extract. N-H absorption of pure chitosan shifted from 1597.06cm-1 to 1640.56cm-1, indicating a crosslinking between ammonium ions in chitosan and phosphate ions from TPP and C. asiatica extract. The formulation of using XRD showed that the amorf form of nanoparticle C. asiatica extracts is supported by particle morphology imaged using SEM. Based on the results obtained, the synthesis of nanoparticles C. asiatica extract in this study has been successful.
Cite this article:
Bayyinatul Muchtaromah, Eko Budi Minarno, Rahmi Annisa, Arif Nur Muhammad Ansori, Ely Nuril Fajriyah, Prilya Dewi Fitriasari, Listiani Suhargo, Kenji Mishima. Synthesis and Optimization of Nanoparticle Chitosan-Tripolyphospate Centella asiatica using Ionic Gelation Method with Difference Sonification Time. Research Journal of Pharmacy and Technology. 2023; 16(8):3847-1. doi: 10.52711/0974-360X.2023.00635
Cite(Electronic):
Bayyinatul Muchtaromah, Eko Budi Minarno, Rahmi Annisa, Arif Nur Muhammad Ansori, Ely Nuril Fajriyah, Prilya Dewi Fitriasari, Listiani Suhargo, Kenji Mishima. Synthesis and Optimization of Nanoparticle Chitosan-Tripolyphospate Centella asiatica using Ionic Gelation Method with Difference Sonification Time. Research Journal of Pharmacy and Technology. 2023; 16(8):3847-1. doi: 10.52711/0974-360X.2023.00635 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-8-55
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