Author(s): Alyaa Ulaa Dhiya Ul Haq, Etty Hary Kusumastuti, Nila Kurniasari, Isnin Anang Marhana


DOI: 10.52711/0974-360X.2023.00630   

Address: Alyaa Ulaa Dhiya Ul Haq1, Etty Hary Kusumastuti2, Nila Kurniasari2, Isnin Anang Marhana3*
1Medical Program, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
2Department of Pathological Anatomy, Faculty of Medicine - Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia.
3Department of Pulmonology, Faculty of Medicine - Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 8,     Year - 2023

Histopathological diagnosis is needed to determine the most appropriate prognosis and therapy for lung and mediastinal tumors, one of the procedures to obtain specimens needed for the examination is a core biopsy. However, core biopsy still requires further evaluation regarding the accuracy and benefits of the technique. This study aims to determine the histopathological features of core biopsy specimens in lung and mediastinal tumors. Designed as a descriptive study using a retrospective approach, we collected medical records of core biopsy results in patients with lung and mediastinal tumors diagnosis at Dr. Soetomo Hospital Surabaya, Indonesia during 1st July 2015-30th June 2020 with total sampling. Of the total 320 cases, 67.8% (n=217) lesions were found in the lung and 32.2% (n=103) in the mediastinum. The most common age distribution for lung tumors was 51-60 years old (34.6%, n=75), while mediastinal tumors were 11-20 years old (20.4%, n=21). Male were more common, both in lung tumors (77.0%, n=167) and mediastinal tumors (61.2%, n=63). The most common histopathological features of lung tumors were lung adenocarcinoma (46.5%, n=101), while in the mediastinum was indeterminate (41.7%, n=43). The age profile of lung tumors is different from that of mediastinal tumors, both are dominated by male. The core biopsy procedure is very useful in establishing the diagnosis of lung and mediastinal tumors. In the indeterminate result, the tissue sample obtained through the core biopsy procedure allows for further molecular examinations including immunohistochemistry, so that a definitive diagnosis can be established.

Cite this article:
Alyaa Ulaa Dhiya Ul Haq, Etty Hary Kusumastuti, Nila Kurniasari, Isnin Anang Marhana. Lung and Mediastinal Tumor Core Biopsies: Histopathological Features of 320 Cases. Research Journal of Pharmacy and Technology. 2023; 16(8):3818-4. doi: 10.52711/0974-360X.2023.00630

Alyaa Ulaa Dhiya Ul Haq, Etty Hary Kusumastuti, Nila Kurniasari, Isnin Anang Marhana. Lung and Mediastinal Tumor Core Biopsies: Histopathological Features of 320 Cases. Research Journal of Pharmacy and Technology. 2023; 16(8):3818-4. doi: 10.52711/0974-360X.2023.00630   Available on:

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