Ibrenna G. Manik, Jansen Silalahi, Yuandani, Denny Satria
Ibrenna G. Manik1, Jansen Silalahi1*, Yuandani2, Denny Satria3
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan 20222, North Sumatera, Indonesia.
2Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan 20222, North Sumatera, Indonesia.
3Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Sumatera Utara, Medan 20222, North Sumatera, Indonesia.
Volume - 16,
Issue - 8,
Year - 2023
Wound healing is a complex process involving many cells consisting of four phases namely hemostasis, inflammation, proliferation, and remodeling. The usage of natural resources that have pharmacological features can hasten the wound's physiological healing procedure. The example of natural resources is virgin coconut oil (VCO) and ethanol extract of Artocarpus lakoocha Roxb. leaves (EEAL) which have the potential for wound healing. This study aimed to examine the combination of VCO and EEAL in an ointment formulation for wound healing in male Wistar rats. The ointment was divided into five formulas with different concentrations of VCO and EEAL and underwent stability and homogeneity evaluation. In vivo animal testing was divided into five groups according to the number of formulas. The wound healing activity was evaluated by using white male rats in the aspect of wound healing percentage and epithelial diameter from a histopathology study. The results showed that all formulas are stable and F3 by using the ratio of 3:1 (VCO: EEAL) has the best wound healing activity in the aspect of wound healing percentage and epithelial diameter compared to the other groups. In conclusion, our findings suggest that the VCO and EEAL in ointment preparation have great potential for wound healing activity.
Cite this article:
Ibrenna G. Manik, Jansen Silalahi, Yuandani, Denny Satria. Wound healing potential of formulated ointment by using virgin coconut oil in combination with Ethanol extract of Artocarpus lakoocha Roxb. leaves. Research Journal of Pharmacy and Technology 2023; 16(8):3530-4. doi: 10.52711/0974-360X.2023.00583
Ibrenna G. Manik, Jansen Silalahi, Yuandani, Denny Satria. Wound healing potential of formulated ointment by using virgin coconut oil in combination with Ethanol extract of Artocarpus lakoocha Roxb. leaves. Research Journal of Pharmacy and Technology 2023; 16(8):3530-4. doi: 10.52711/0974-360X.2023.00583 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-8-3
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