Author(s): Pritam Rajkumar Siraskar, Dinesh Kumar Mishra

Email(s): ,

DOI: 10.52711/0974-360X.2023.00608   

Address: Pritam Rajkumar Siraskar1*, Dinesh Kumar Mishra2
1School of Health Science and Pharmacy, Career Point University, Kota, Rajasthan.
2Professor, Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur (C.G.) 495009.
*Corresponding Author

Published In:   Volume - 16,      Issue - 8,     Year - 2023

In order to regulate its release, avoid repeated dosing, and consequently maximize bioavailability, it is essential to develop and construct floating microspheres of glipizide. According to Strubel et al., HPMC and EC were combined to form glipizide-loaded floating microspheres using a solvent evaporation technique. Drug loading, particle size, and percent drug release were used as response factors in the formulation optimization process, which took into account polymer concentration and stirring rate as independent variables.The bulk density, tapped density, flowability, and particle size of the formulation batches were all evaluated. Its in-vitro performance was assessed using the standard pharmacopoeal assays as well as other procedures, including yield (%), drug polymer compatibility (FTIR scan), and tapped density (%). Analysis of compressibility particle size, drug entrapment effectiveness, surface topography (SEM), and an in vitro release research. with a yield of 88.30±0.53%, an ideal drug loading of 85.50±0.55%, and a preferred buoyancy of 91.93±0.61%, tiny to big and spherical microspheres were created at 40°C using a 1:6 polymer, 2% Tween 80, and that temperature. The development of a stable emulsion and equally sized internal phase droplets was largely dependent on the emulsifying agent. A crucial element in the emulsification process is the propeller's stirring speed. Additionally, it influences the droplets' size and shape, which has an impact on the microspheres. The decision was made to incorporate stirring rate and polymer concentration as independent variables in the experimental design while keeping the other variables fixed as a result of the debate that was just had. Measurements of the hypoglycemic response brought on by oral administration were used to determine the in vivo effectiveness of the optimized batch in healthy normal Wistar rats (250–300gm).

Cite this article:
Pritam Rajkumar Siraskar, Dinesh Kumar Mishra. In-vivo Estimation of Optimized Floating Microspheres Design by QBD approach. Research Journal of Pharmacy and Technology 2023; 16(8):3697-0. doi: 10.52711/0974-360X.2023.00608

Pritam Rajkumar Siraskar, Dinesh Kumar Mishra. In-vivo Estimation of Optimized Floating Microspheres Design by QBD approach. Research Journal of Pharmacy and Technology 2023; 16(8):3697-0. doi: 10.52711/0974-360X.2023.00608   Available on:

1.    American Diabetes Association. Diagnosis and classification for diabetes mellitus. Diabetes Care. 2004; 27: 5-10.
2.    Bonner-Weir S, Orei L. New perspectives on the microvasculature of the islets of langerhans in the rat diabetes. Diabetologia. 1982; 31: 883-889.
3.    Kawashima Y., Niwa T., Takeuchi H., Hino T., Ito Y., Preparation of multiple unit hollow microspheres (microballoons) with acrylic resins containing tranilast and their drug release characteristics (in vivo). J Control Release. 16(1991), 279-290.
4.    Khan G. M., Controlled Release Oral Dosage Forms. Some Recent Advances in matrix type drug delivery systems. The Sciences, 1 (5) (2001), 350-354.
5.    A. J. Moes, Gastroretentive dosage forms, Crit. Rev. Ther. Drug. Carrier Syst. 10 (1993) 143-195.
6.    A. A. Deshpande, C.T. Rhodes, N.H. Shah and A.W. Malick, Controlled release drug delivery system for prolonged gastric residence an overview. Drug Dev. Ind. Pharm. 22. (1996) 531-539.
7.    Lee J. W., Park J .H, Robinson J.R., Bioadhesive-Based Dosage forms: The Next Generation. J. Pharm. Sci. 89(7), (2000), 850-866
8.    Shrivastava A. K., Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation. Acta Pharm. 55(2005), 277-285.
9.    Ray S., In vitro evaluation and optimization of controlled release drug delivery system of Metformin Hydrochloride. DARU, 14(2), (2006).
10.    Ozdemir N., Ordu S., Ozkan Y., Studies of floating dosage forms of furosemide: in vitro and in vivo evaluation of bilayer tablet formulation. Drug Dev Ind Pharm. 26(2000), 857-866.
11.    Streubel A, Siepmann J, Bodmeier R. Multiple unit Gastroretentive drug delivery: a new preparation method for low density microparticles. J Microencapsul. 2003; 20: 329-347.
12.    Williams DA, Lemke TL, Williams L. Insulin and Oral Hypoglycemic drugs. In Foye’s Principles of Medicinal Chemistry, 5th Ed. New York Lippincott Williams and Wilkins: 2002. P. 641-648.
13.    Foster RH, Plosker GL, Glipizide: a review of the pharmacoeconomic implication of the extended release formulation in type 2 diabetes mellitus capsules encapsulated excipients.
14.    Kahn C.R., Shechter Y., Oral hypoglycemic agents and the pharmacology of the endocrine pancreas. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. New York, NY: McGraw-Hil; 8(1991), 1461-1495.
15.    Sonia Chauhan, Rupa Mazumder, Rakhi Mishra, Avijit Mazumder, Nidhi Srivastava. Formulation, Development and Release Enhancement of Sustained Release Tablet of Antidiabetic Drug Glipizide by the use of Natural Polymers. Research Journal of Pharmacy and Technology. 2022; 15(4):1588-3.
16.    VedanshuMalviya, Ankit Arya, Prashant Burange, Kalpak Gajbhiye, GauriRathod, MukundTawar. To Evaluate the Cardioprotective effect of Hydroalcoholic Extract of Matricariachamomilla Linn in Isoproterenol Induced Myocardial Infarction in Wistar Rats. Research Journal of Pharmacy and Technology. 2022; 15(9):3887-2.
17.    A. Anka Rao, K. Pavan Kumar, A. Narayana Rao, NarenderMalothu, B. Prassana Kumar Desu, Naga RajuBandaru. Rapid Quantitative Estimation of Glipizide and Sitagliptin in Rat Plasma by Liquid Chromatography and Mass spectroscopy (LC-MS). Research Journal of Pharmacy and Technology. 2022; 15(4):1675-9.
18.    Vikas B Gawali, Niraj S Vyawahare. Anti-Hyperglycemic effect of Polyherbal Formulation in Glucose Loaded and Epinephrine Induced Hyperglycemic Wistar rats. Research Journal of Pharmacy and Technology. 2022; 15(1):365-9.
19.    Himani Gupta, Manish Kumar Shakya, Gyanendra Kumar Sharma. Evaluation of Anti-ulcer activity of Polyherbal preparation in Ulcerogenic Wistar rats. Research Journal of Pharmacy and Technology. 2022; 15(8):3471-4.
20.    Khushbu Patel, Ujashkumar A. Shah, Hirak V. Joshi, Jayvadan K. Patel, Chhaganbhai N. Patel. QbD Stressed Development and Validation of Stability-Indicating RP- HPLC Method for the Simultaneous Estimation of Linagliptin and Metformin HCl in Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2022; 15(5):1917-3.
21.    PushprajMujalde, Sourabh Jain, Karunakar Shukla. Evaluation of Toxicity and Antidiabetic Activity of Ethanolic Extract of Flowers of Moringaoleifera against Dexamethasone Induced Hyperglycemia in Albino Wistar Rats. Research Journal of Pharmacy and Technology. 2022; 15(2):517-4.
22.    S. Sivaprasad, V. Alagarsamy, M. PrathibhaBharathi, P.V. Murali Krishna, K. SandeeepKanna. Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11):5673-9.
23.    Ajeet Singh, Ranjit Singh. Development and Characterization of Repaglinide Loaded Floating Microparticles. Research Journal of Pharmacy and Technology. 2021; 14(12):6573-8.
24.    Anupam K Sachan, Saurabh Singh, KiranKumari, Pratibha Devi. Floating Microsphere of Curcumin as Targeted Gastro-retentive Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(10):5202-6.
25.    Sagar Firke, Ashish Roge, Nitin Ghiware, S.B. Dhoot, S.M. Vadwalkar. Floating Microspheres as Gastro-Retentive Drug Delivery System: A Review. Research J. Pharm. and Tech. 6(12): Dec. 2013; Page 1452-1458.

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