Author(s):
Haritha P H, T. Lakshmi Narayanan, Amrita Babu, G. Ariharasivakumar, Dithu Thekkekkara
Email(s):
dithuthekkekkara@jssuni.edu.in
DOI:
10.52711/0974-360X.2023.00602 
Address:
Haritha P H1, T. Lakshmi Narayanan2, Amrita Babu2, G. Ariharasivakumar3, Dithu Thekkekkara4*
1M. Pharm, Dept. of Pharmacology, KMCH College of Pharmacy, Coimbatore, India.
2M. Pharm, Dept. of Pharmacology, JSS College of Pharmacy, Mysuru, India.
3Professor, Dept. of Pharmacology, KMCH College of Pharmacy, Coimbatore, India.
4Lecturer, Dept. of Pharmacology, JSS College of Pharmacy, Mysuru, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 8,
Year - 2023
ABSTRACT:
Aim: The current research aims to evaluate and scientifically validate the ani-amnestic potential of ayruvedic formulation Saraswathaghrita (SG) in the scopolamine-induced rat model. Materials and methods: The animals were pretreated with different doses of SG (100mg/kg, 200mg/kg, and 400mg/kg) for seven days before scopolamine induction. For induction of amnesia, scopolamine was injected i.p (single dose of 2mg/kg) in rats for seven consecutive days. 1 hour before induction different doses of SG were administrated (p.o). On the 7th day after 1-hour of induction, various behavioral studies, biochemical estimations, neurotransmitter evaluations, and histopathological studies were performed. Results: The escape latency time in the Morris water maze was significantly increased in 400mg/kg SG treated group compared to the scopolamine-induced group (31.667± 1.174). Treatment with various doses of SG significantly decreases the no. of attempts and latency time (3.167± 0.307 and 7.700±0.383, 2.667±0.211 and 6.617±0.387 and 2.333±0.211 5.267±0.616). Treatment with SG results in regaining the levels of endogenous antioxidant levels to normal values compared to the scopolamine-induced group. In the case of acetylcholinesterase activity, SG treated group, there was a significantly decreased level of acetylcholinesterase (0.611±0.027) compared with the scopolamine-induced group (1.142±0.049). The neuroprotective effect of SG was confirmed by histopathology. The inflammatory cells were absent, glial and astrocytes possess proper morphological features in SG treated group. Conclusion: SG possesses potent anti-cholinesterase inhibition potential and anti-oxidant properties which leads to its anti-amnestic property in the scopolamine-induced rat model.
Cite this article:
Haritha P H, T. Lakshmi Narayanan, Amrita Babu, G. Ariharasivakumar, Dithu Thekkekkara. Evaluvation of Anti-amnesic activity of Ayurvedic formulation Saraswathaghrita in the scopolamine-induced rat model. Research Journal of Pharmacy and Technology 2023; 16(8):3658-4. doi: 10.52711/0974-360X.2023.00602
Cite(Electronic):
Haritha P H, T. Lakshmi Narayanan, Amrita Babu, G. Ariharasivakumar, Dithu Thekkekkara. Evaluvation of Anti-amnesic activity of Ayurvedic formulation Saraswathaghrita in the scopolamine-induced rat model. Research Journal of Pharmacy and Technology 2023; 16(8):3658-4. doi: 10.52711/0974-360X.2023.00602 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-8-22
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