Author(s): Saira Asghar, Nousheen Mushtaq, Ahsaan Ahmad, Rabya Munawwar, Sumaira Ansari, Syeda Abiha Rizvi


DOI: 10.52711/0974-360X.2023.00597   

Address: Saira Asghar1,2, Nousheen Mushtaq1, Ahsaan Ahmad3, Rabya Munawwar4, Sumaira Ansari1, Syeda Abiha Rizvi5l
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan.
3Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan.
4Dow College of Pharmacy, Dow University of Health Science, Karachi, Pakistan.
5Jinnah College of Pharmacy, Sohail University, Karachi, Pakistan.
*Corresponding Author

Published In:   Volume - 16,      Issue - 8,     Year - 2023

Oxidative stress is one of the main causative factors for pathogenesis of numerous disorders including psychological and neurodegenerative diseases (Alzheimer’s disease and Parkinsonism). Amyloid aggregates induced oxidative stress is involved in disfunction and degeneration of brain cells in Alzheimer’s disease. Antioxidants are important natural or synthetic molecules having tendency to curb free radicals and discontinuing their chain reactions prior to the damage of essential biomolecules. Drugs possessing antioxidant activity are being extensively anticipated for developing novel therapeutic agents in numerous pathological conditions accompanying oxidative stress like AD. In this study twelve tryptamine derivatives were synthesized and investigated for antioxidant, fibril inhibition and disaggregation potential. In vitro antioxidant potential of the derivatives was examined by using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and revealed that SR10, SR14, SR23 and SR42 displayed better antioxidant activity (IC50 in the range of 0.75±0.05µM-14.43±0.77µM) than the standard ascorbic acid (IC50 =15.83±0.88µM). In vitro amyloid fibril inhibition and disaggregation assay was carried out by using HEWL (Hen egg white lysozyme) presenting moderate to high inhibition/disaggregation activities. Molecular dockingassessment recognized themode of bindingswithin active site of human antioxidant enzyme peroxiredoxin (PDB ID: 3MNG). These tryptamine derivatives with potential antioxidant and inhibition/disaggregation activitieswill be beneficialto develop and designdrug molecules forneurodegenerative disorders.

Cite this article:
Saira Asghar, Nousheen Mushtaq, Ahsaan Ahmad, Rabya Munawwar, Sumaira Ansari, Syeda Abiha Rizvi. Design, Synthesis and Therapeutic investigation of Tryptamine derivatives as Potential Antioxidant and Amyloid inhibitor/disaggregator. Research Journal of Pharmacy and Technology 2023; 16(8):3622-2. doi: 10.52711/0974-360X.2023.00597

Saira Asghar, Nousheen Mushtaq, Ahsaan Ahmad, Rabya Munawwar, Sumaira Ansari, Syeda Abiha Rizvi. Design, Synthesis and Therapeutic investigation of Tryptamine derivatives as Potential Antioxidant and Amyloid inhibitor/disaggregator. Research Journal of Pharmacy and Technology 2023; 16(8):3622-2. doi: 10.52711/0974-360X.2023.00597   Available on:

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