Author(s): Jastria Pusmarani, Citra Dewi, Risky Juliansyah Putri, Nur Hatidjah Awaliyah Halid, Sasri Intan Febriani, Febrianti Husni, Setyo Purwono, Zullies Ikawati


DOI: 10.52711/0974-360X.2023.00596   

Address: Jastria Pusmarani1*, Citra Dewi2, Risky Juliansyah Putri2, Nur Hatidjah Awaliyah Halid2, Sasri Intan Febriani3, Febrianti Husni3, Setyo Purwono4, Zullies Ikawati5
1Department of Pharmacology and Clinical Pharmacy of Universitas Mandala Waluya, Kendari, Indonesia.
2Department of Phytochemical of Universitas Mandala Waluya, Kendari, Indonesia.
3Department of Pharmacy of Universitas Mandala Waluya, Kendari, Indonesia.
4Department of Pharmacology and Therapy of Universitas Gadjah Mada, Yogyakarta, Indonesia.
5Department of Pharmacology and Clinical Pharmacy of Universitas Gadjah Mada, Yogyakarta, Indonesia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 8,     Year - 2023

Gastric ulcers are caused by excessive gastric acid secretion, alcohol, and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin is one of the NSAIDS that can induce peptic ulcers. Traditional medicines that have been proven to have gastroprotective activity is Andrographis paniculata (APAC). The purpose of this study is to assess the antioxidant activity and gastroprotective effect of purified extract of APAC. The herbal treatment was given for 7 days, and on the eighth day, all groups except the negative control (Na CMC 0.5%) were given 1000mg/kgBW of aspirin. Six hours later, the rats were sacrificed and opened for macroscopic examination, pH gastric juice value, the volume of gastric value, ulcer index, and inhibition percentage. Antioxidant studies using 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that APAC has strong antioxidant activity with IC50 value = 64.54. APAC could reduce the occurrence of gastric ulcers by decreasing gastric pH, ulcer index, and increasing inhibition percentage (P=0.000<0.05). Andrographis paniculata has gastroprotective properties associated with antioxidant activity.

Cite this article:
Jastria Pusmarani, Citra Dewi, Risky Juliansyah Putri, Nur Hatidjah Awaliyah Halid, Sasri Intan Febriani, Febrianti Husni, Setyo Purwono, Zullies Ikawati. In vitro and In vivo Study of Gastroprotective effect of Purified Extract Andrographis paniculata. Research Journal of Pharmacy and Technology 2023; 16(8):3615-1. doi: 10.52711/0974-360X.2023.00596

Jastria Pusmarani, Citra Dewi, Risky Juliansyah Putri, Nur Hatidjah Awaliyah Halid, Sasri Intan Febriani, Febrianti Husni, Setyo Purwono, Zullies Ikawati. In vitro and In vivo Study of Gastroprotective effect of Purified Extract Andrographis paniculata. Research Journal of Pharmacy and Technology 2023; 16(8):3615-1. doi: 10.52711/0974-360X.2023.00596   Available on:

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