ABSTRACT:
Ketoprofen is the non-steroidal anti-inflammatory drug which is a propionic acid derivative and is a non-selective COX-inhibitor. It is frequently used in case of osteo and rheumatoid arthritis and other inflammatory conditions. This drug having side effect of gastric ulcer which occur due to free carboxylic acid group present in its structure. Here, we synthesized the ester linked prodrugs of ketoprofen conjugated with different phytophenols. All the synthesized chemical entities were characterized by IR-spectroscopy, 1H-NMR, 13C-NMR and mass spectrometry. All the prodrugs showed significant analgesic and anti-inflammatory effect and less ulcerogenic potential.
Cite this article:
Gaurav Krishna, Kamal Shah. Design, Synthesis, Chemical Characterization and In-vivo Screening of Prodrugs. Research Journal of Pharmacy and Technology 2023; 16(7):3427-3. doi: 10.52711/0974-360X.2023.00567
Cite(Electronic):
Gaurav Krishna, Kamal Shah. Design, Synthesis, Chemical Characterization and In-vivo Screening of Prodrugs. Research Journal of Pharmacy and Technology 2023; 16(7):3427-3. doi: 10.52711/0974-360X.2023.00567 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-64
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