Author(s): Abhinaya N., Muddukrishna B.S., Ravindra Shenoy, Raveendra Pai, Girish Thunga, Sohil A. Khan, Girish Pai K.

Email(s): girish.pai@manipal.edu

DOI: 10.52711/0974-360X.2023.00562   

Address: Abhinaya N.1, Muddukrishna B.S.2, Ravindra Shenoy3, Raveendra Pai4, Girish Thunga5, Sohil A. Khan6, Girish Pai K.7*
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal.
2Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal.
3Department of Commerce, Manipal Academy of Higher Education (MAHE), Manipal.
4Formulation Development, Glenmark Pharmaceuticals Limited M-4, Taloja MIDC, Taloja, Maharashtra, India.
5Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal.
6Pharmacotherapeutics and Evidence-Based Practice School of Pharmacy and Pharmacology, Griffith University 4222 Queensland, Australia.
7Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal.
*Corresponding Auth

Published In:   Volume - 16,      Issue - 7,     Year - 2023


ABSTRACT:
An ideal tablet should be of high quality and devoid of flaws. Tablet defects can lead to therapeutic failure and reduce the patient compliance in case of clinical perspective whereas it also imparts financial burden, loss of production time and reputation of the company. The research was carried out to investigate and find out the possible root causes of the broken tablet within the intact blister. Oral dosage forms were visually inspected in a hospital pharmacy in the Udupi district, using a validated checklist. A powdered uncoated Fluconazole tablet was found within the intact blister pocket of 1’s pack. A case study was formulated comprising of the dosage form, generic name, therapeutic category, probable root causes, defects, category of complaint, probable root causes and remediation and clinical significance. This unique outcome of the work can be used to train the health professionals which will further help them in avoiding such defects and defective products reaching the patients. Such defects can be bypassed by giving effective training to the staff using real-life case studies, taking corrective and preventive actions and conducting adequate in-process quality checks before releasing the products into the market. The use of such case studies will be effective in learning better and developing their skills in problem-solving and decision-making in ambiguous/complex situations.


Cite this article:
Abhinaya N., Muddukrishna B.S., Ravindra Shenoy, Raveendra Pai, Girish Thunga, Sohil A. Khan, Girish Pai K. A Systematic Investigation and Suggested Remedies for a Defective Marketed Solid Dosage Form. Research Journal of Pharmacy and Technology 2023; 16(7):3399-4. doi: 10.52711/0974-360X.2023.00562

Cite(Electronic):
Abhinaya N., Muddukrishna B.S., Ravindra Shenoy, Raveendra Pai, Girish Thunga, Sohil A. Khan, Girish Pai K. A Systematic Investigation and Suggested Remedies for a Defective Marketed Solid Dosage Form. Research Journal of Pharmacy and Technology 2023; 16(7):3399-4. doi: 10.52711/0974-360X.2023.00562   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-59


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