Author(s): Reham Talib Imran, Ahmed H. Jwaid

Email(s): rehamtaleb@yahoo.com

DOI: 10.52711/0974-360X.2023.00561   

Address: Reham Talib Imran*, Ahmed H. Jwaid
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad - Iraq.
*Corresponding Author

Published In:   Volume - 16,      Issue - 7,     Year - 2023


ABSTRACT:
Background: Drug-induced nephrotoxicity is one of the most common causes of acute kidney injury. Cisplatin is one of the most effective and potent anticancer drugs, induces a reduction in the antioxidant, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drug. Objectives: This study was conducted to examine the possible ameliorative activity of Daflon against Cis-induce acute kidney injury. Materials and methods: Animals divided into six groups, group ?: received NaCl on a daily; group ??: received Cisplatin (7.5mg/kg) single dose; group ???: received Daflon mini dose (50mg/kg) for 15 successive days, group IV: received Daflon max dose (100mg/kg/day) for 15 successive days; group V: received Daflon mini dose (50mg/kg) for 15 successive days and a single IP dose of Cisplatin (7.5mg/kg) to be injected on day 15, group VI : received Daflon max dose (100mg/kg) for 15 successive days and a single IP dose of Cisplatin (7.5mg/kg) to be injected on day 15, Finally, after euthanization of each animal by diethyl ether, the samples were collected for analysis. Serum MDA, Serum GSH and Tumor Necrosis Factor (TNF-a) had been used as an indicator for the protective effect of Daflon. Conclusion: The results show that administration of Daflon for 15 days had significant protective effect against cisplatin induced nephrotoxicity.


Cite this article:
Reham Talib Imran, Ahmed H. Jwaid. The Possible Protective effect of Daflon 500mg on Cisplatin Induce Nephrotoxicity in Experimental Rats. Research Journal of Pharmacy and Technology 2023; 16(7):3393-8. doi: 10.52711/0974-360X.2023.00561

Cite(Electronic):
Reham Talib Imran, Ahmed H. Jwaid. The Possible Protective effect of Daflon 500mg on Cisplatin Induce Nephrotoxicity in Experimental Rats. Research Journal of Pharmacy and Technology 2023; 16(7):3393-8. doi: 10.52711/0974-360X.2023.00561   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-58


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