Author(s): Patel Ravindrakumar K, Patel Sandip B, Vyas Niraj

Email(s): nirajvyas.ph@charusat.ac.in

DOI: 10.52711/0974-360X.2023.00557   

Address: Patel Ravindrakumar K1, Patel Sandip B2, Vyas Niraj3*
1Department of Pharmacology, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Anand, Gujarat, India.
2Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad, Gujarat, India.
3Department of Pharmacognosy and Phytochemistry, Ramanbhai Patel College of Pharmacy (RPCP), Charotar University of Science and Technology (CHARUSAT), Charusat campus, Changa, Dist. Anand, Gujarat, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 7,     Year - 2023


ABSTRACT:
This research aimed to assess the effect of Ocimum basilicum L. seed extract on the urolithiasis. Rats were treated with Cystone (750mg/kg) and hydro-alcoholic extracts in 250 and 500mg/kg doses for 28days. On Day 29, Ethylene glycol induced urolithiasis was verified by evaluating urinary parameters, biochemical parameters, oxidative stress parameters and histology of kidneys. Extract treatment attenuated the urinary parameter elevation and biochemical serum parameters induced by the evidence. Extract treatment also reversed induced changes in urine volume, pH and Magnesium and creatinine clearance, oxidative and histological damage to the EG-caused kidneys. The histology of treated group showed small and low deposits of calculi in the kidney. Extract showed potential calcium oxalate crystal formation, diuretic, antioxidant activity and preserving the balance between stone promoters and inhibitors. This validated study rationalized its medicinal use in urolithiasis.


Cite this article:
Patel Ravindrakumar K, Patel Sandip B, Vyas Niraj. Assessment of Anti-urolithic effect of the Ocimum basilicum L. seed extract on Ethylene Glycolinduced urolithiasis in male rats. Research Journal of Pharmacy and Technology 2023; 16(7):3367-2. doi: 10.52711/0974-360X.2023.00557

Cite(Electronic):
Patel Ravindrakumar K, Patel Sandip B, Vyas Niraj. Assessment of Anti-urolithic effect of the Ocimum basilicum L. seed extract on Ethylene Glycolinduced urolithiasis in male rats. Research Journal of Pharmacy and Technology 2023; 16(7):3367-2. doi: 10.52711/0974-360X.2023.00557   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-54


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