Author(s):
Harly Prabowo, Patricia Samantha, Karina Mundiratri, Ananda Firman Putranto
Email(s):
harly-p@fkg.unair.ac.id
DOI:
10.52711/0974-360X.2023.00553
Address:
Harly Prabowo1*, Patricia Samantha2, Karina Mundiratri1, Ananda Firman Putranto3
1Department of Prosthodontic, Faculty of Dental Medicine, Universitas Airlangga Surabaya – Indonesia.
2Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya – Indonesia.
3Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga Surabaya – Indonesia.
*Corresponding Author
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
Objective: The implant material that is often used is Ti-6Al-4V (grade 5 titanium). One of the requirements for successful implant placement is osseointegration which is a structural and functional relationship between the bone and the implant surface. To improve the osseointegration of the implant, modifications can be made to the implant surface, one of which is sandblasting which serves to make the implant surface rough enough to increase mechanical interlocking which allows better cell attachment. But on the other hand, this technique can reduce the endurance of the implant so it increases the possibility of fracture of the implant. Aim: The aim of the study is to determine the changes in the properties of Ti-6Al-4V after being sandblasted with 50µm AL2O3. 16 Ti-6Al-4V implants that had been blasted with 50µm AL2O3 and 16 Ti-6Al-4V implants without sandblast were given dynamic treatment with a pressure of 100 N for 2 million times, with a frequency of 15 Hz and then tested with a compressive test. Result: There was a significant average difference between the two groups as indicated by the results in the group without surface treatment (1682 N) and in the group that was sandblasted with 50 µm Al2O3 (815 N). Conclusion: Sandblasting using 50µm Al2O3 can reduce the endurance of Ti-6Al-4V implants because microcracks left by Al2O3 on the implant surface can lead to fracture initiation.
Cite this article:
Harly Prabowo, Patricia Samantha, Karina Mundiratri, Ananda Firman Putranto. Change of Compressive Strength Ti-6al-4v Sandblasted Al2O3 50μm Post Dynamic Pressure Treatment In vitro. Research Journal of Pharmacy and Technology 2023; 16(7):3349-2. doi: 10.52711/0974-360X.2023.00553
Cite(Electronic):
Harly Prabowo, Patricia Samantha, Karina Mundiratri, Ananda Firman Putranto. Change of Compressive Strength Ti-6al-4v Sandblasted Al2O3 50μm Post Dynamic Pressure Treatment In vitro. Research Journal of Pharmacy and Technology 2023; 16(7):3349-2. doi: 10.52711/0974-360X.2023.00553 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-50
REFERENCES:
1. Ahamed Noor Mansoori, Rupesh K. Gautam, Prafulla C. Tiwari. A Review on Genotoxicity. Asian J. Pharm. Res. 4(3): 2014 Sept.; Page 162-165.available on: https://asianjpr.com/AbstractView.aspx?PID=2014-4-3-7
2. Ashok B. Patel, Ashish H. Asnani, Amitkumar J. Vyas, Nilesh K. Patel, Ajay I. Patel, Arvind N. Lumbhani. A Brief Review on Genotoxic impurities in Pharmaceuticals. Asian Journal of Pharmaceutical Research. 2021; 11(3):187-3. doi: 10.52711/2231-5691.2021.00034
3. Pilaniya K, Chandrawanshi HK, Pilaniya U, Manchandani P, Jain P, Singh N. Recent trends in the impurity profile of pharmaceuticals. Journal of Advanced Pharmaceutical Technology and Research. July 2010; 1(3):302-5.doi: 10.4103/0110-5558.72422
4. Raman NV, Reddy KR, Prasad AV, Ramakrishna K. Development and validation of RP-HPLC method for the determination of genotoxic alkyl benzenesulfonates in amlodipine besylate. Journal of pharmaceutical and biomedical analysis. 2008 Sep; 48(1):227-30.doi: 10.1016/j.jpba.2008.05.021
5. Debnath S, Jeyaprakash MR, Bora R, Nagappan KV, Krishnan NJ. Simultaneous Method for Quantification of Genotoxic Impurity in the Gemcitabine Hydrochloride by RP-HPLC. Journal of Young Pharmacists. 2019 April ;11(2):136.doi: 10.5530/jyp.2019.11.30
6. Sravanthi D, Babu DJ, Babu BN. Formulation and evaluation of Gemcitabine HCl anti-cancer lyophilized powder for injection. Indian Journal of Research in Pharmacy and Biotechnology. 2017 February;5(1):54-57.available on: https://www.ijrpb.com/issues/ijrpb% 205(1)%2012%20Jeevan%203%2054-57%20c.pdf
7. M. Yogeshwar Reddy, V. Ramesh, Ch. Kista Reddy, N. Venugopal, G.Saravanana, M.V. Suryanarayana, B. Shyam Sunder, R.Surendranath Reddy, G. Raju. Validated Chromatographic Method for the Determination of Process Related Genotoxic Impurity in Lansoprazole. Asian J. Research Chem. June 2011; 4(6): 965-967.available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-6-26
8. Pranabesh Sikdar. Hepatoprotective activity of the hydro-alcoholic extract of the Gracilariaedulis (Gmelin). Research J. Pharm. and Tech.2017; 10(6): 1647-1652. doi: 10.5958/0974-360X.2017.00290.6
9. Mastanamma S, Ramkumar G, Kumar DA, Rao JV. A stability indicating RP-HPLC method for the estimation of gemcitabine HCl in injectable dosage forms. E-journal of Chemistry. 2010 January 2(7);239-44.https://doi.org/10.1155/2010/724915
10. Wasim Raja, Sonam Pandey, SarfarazHanfi, R.C. Agrawal. Effect of Phyllanthusniruri Leaf Extract on Antioxidant Activity and UV Induced Chromosomal Aberration in Swiss Albino Mice. Research J. Pharmacognosy and Phytochemistry 2011; 3(6): 300-303.available on: https://rjpponline.org/AbstractView.aspx?PID=2011-3-6-12
11. Debnath S, Vanitha G, Bindu HP, Babu NM. Applications of organogels in drug delivery. Indian journal of research in pharmacy and biotechnology. 2014 January; 2(1):976-981. available on:https://ijrpb.com/issues/Volume%202_Issue%201/ijrpb%202(1)%207%20 subhasish%20corrected%20976-981.pdf
12. V. Suresh. et.al. Evaluation of Genotoxic Effect of Cashew nut Kernel Oil. Research J. Pharmacology and Pharmacodynamics. 2010 May; 2(4): 274-277.available on: https://rjppd.org/AbstractView.aspx?PID=2010-2-4-15
13. Brown K.A linear synthesis of gemcitabine.Carbohydrate research.215 April;406:715. doi:10.1016/j.carres.2015.01.001
14. Murugan S., Subhashis Debnath, Pranabesh Sikdar, NiranjanBabu M. Simultaneous Estimation of TenofovirDisoproxilFumarate, Efavirenz and Lamivudine in Bulk and Tablet Dosage Form by UV Spectrophotometry.2013;191-194.available on: https://rjptonline.org/AbstractView.aspx?PID=2013-6-2-4
15. Besançon OG. Tytgat GA. Meinsma R, Leen R. et al. Synergistic interaction between cisplatin and gemcitabine in neuroblastoma cell lines and multicellular tumor spheroids. Cancer letters. 2012 June;19(1):23-30. doi: 10.1016/j.canlet.2011.12.016
16. Wang G.et al. Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics. 2017 Sep 1; 12(5):478-85. doi: 10.1016/j.ajps.2017.01.001
17. R. Suresh Kumar, Subhashish Debnath, GNK Ganesh, L Raju, MK Samantha, B Suresh. Chitosan Nano Particles by Ionotropic Gelatin Containing L-Arginine. Research J.pharm. and Tech. 2009 January;2(1): 80-85. availableon:https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2009-2-1-1
18. Picozzi VJ, Ramanathan RK, Lowery MA, Ocean AJ, Mitchel EP, O’Neil BH, Guarino MJ, Conkling PR, Cohen SJ, Bahary N, Frank RC. 90Y-clivatuzumab tetraxetan with or without low-dose gemcitabine: A phase Ib study in patients with metastatic pancreatic cancer after two or more prior therapies. 2015 September; 51(14):1857-64. doi: 10.1016/j.ejca.2015.06.119
19. Minami K, Shinsato Y, Yamamoto M, Takahashi H, Zhang S, Nishizawa Y, Tabata S, Ikeda R, Kawahara K, Tsujikawa K, Chijiiwa K. Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors. 2015 March; 127(3):319-25. doi: 10.1016/j.jphs.2015.01.006
20. Ryu H, Kang E, Park S, Park S, Lee K, Joo KW, Lee H. A case of gemcitabine-induced thrombotic microangiopathy in an urothelialtumor patient with a single kidney. 2015 December; 34(4):237-40. doi: 10.1016/j.krcp.2015.06.001
21. Dhrubajyoti Sarkar, Subhashis Debnath, Sekhar Kumar Bose. Phytochemical analysis and assessment of Antioxidant properties of black tea extract obtained from Camellia sinensis. 2020; 13(10):4539-4544.doi: 10.5958/0974-360X.2020.00800.8
22. Chen HM, Pan CC, Tsai CM, Hsu WH, Yang SH, Yen CC. Concomitant primary lung cancer and metastatic pulmonary colorectal cancer that responded to gemcitabine/cisplatin/bevacizumab combination therapy. 2015 March; 2(1):76-82. doi: 10.2147/DDDT.S116286
23. P Ravi Kumar, P Spandana, Amani Shareef, K Sahithi, N RaghavendraBabu. Development and Validation of Difference Spectrophotometric Method for Quantitative Estimation of Gemcitabine Hydrochloride Injection. 2019 March; 9(4):219-223. doi: 10.5958/2231-5675.2019.00037.1
24. Alexander M. Luke, Al Moutassem B. Khair, Syed Kudrutullah, Simy Mathew, Salem A. Fanas, Krishna P. Shetty, RajashreePatnaik. Evaluation of genotoxicity in buccal mucosa of patients subjected to X-rays by degenerative nuclear alterations study. Research Journal of Pharmacy and Technology. 2021; 14(11):5845-8.doi:10.52711/0974-360X.2021.01017
25. P. Sangeetha, V. Anuradha. Antigenotoxicity, Cytogenetic Assay measuring Chromosomal Aberration and Antimicrobial Activity of Methanolic Extract of Microalgae: Nannochloropsisoculate. Research J. Pharm. and Tech 2020; 13(5): 2297-2302.doi:10.5958/0974-360X.2020.00414.X