Author(s):
Palla Mary Sulakshana, G. Girija Sankar, Jagadeesh Panda, K. Padmaja
Email(s):
mary.pharma114@gmail.com
DOI:
10.52711/0974-360X.2023.00552 
Address:
Palla Mary Sulakshana1, G. Girija Sankar2, Jagadeesh Panda3, K. Padmaja3
1GITAM School of Pharmacy, GITAM Deemed to be University, Visakhapatnam , India-530045.
2Andhra University, College of Pharmaceutical Sciences, Department of Pharmaceutical Biotechnology,
Andhra University, Visakhapatnam, Andhra Pradesh, 530 003, India.
3Raghu College of Pharmacy, Dakammari, Bheemunipatnam, Visakhapatnam, Andhra Pradesh, 531162, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
Mangroves are found to be an excellent source for the isolation of novel bioactive metabolite producing microorganisms. Streptomyces hydrogenans KMFA-1, isolated from mangrove soil sample is exclusively known for its potent activity against various pathogenic fungi. The present study is focused on strain improvement of Streptomyces hydrogenans KMFA-1 by physical and chemical mutagens such as ultraviolet irradiation and nitrous acid (HNO2) respectively, for enhancing the production of antifungal metabolite against C. albicans and Pectinotrichum llanense. The parent isolate KMF-A1 produced 20mm inhibition zone diameter of antifungal activity while, the UV mutant designated as UV7, yielded 28mm and the nitrous acid mutant. UV7N4 (KMF-A1) exhibited 30mm inhibition zone diameter. The mutant strain produced improved antifungal activity by 1.5-fold increase with respect to wild strain.
Cite this article:
Palla Mary Sulakshana, G. Girija Sankar, Jagadeesh Panda, K. Padmaja. Strain improvement of Streptomyces hydrogenans KMF-A1 for Antifungal Metabolite Production. Research Journal of Pharmacy and Technology 2023; 16(7):3343-8. doi: 10.52711/0974-360X.2023.00552
Cite(Electronic):
Palla Mary Sulakshana, G. Girija Sankar, Jagadeesh Panda, K. Padmaja. Strain improvement of Streptomyces hydrogenans KMF-A1 for Antifungal Metabolite Production. Research Journal of Pharmacy and Technology 2023; 16(7):3343-8. doi: 10.52711/0974-360X.2023.00552 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-49
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