Author(s): Devlina Pal, Asim Halder, Dibya Das, Himangshu Sekhar Maji

Email(s): hsmaji@jisuniversity.ac.in

DOI: 10.52711/0974-360X.2023.00544   

Address: Devlina Pal1, Asim Halder2, Dibya Das1, Himangshu Sekhar Maji1*
1Department of Pharmaceutical Technology, JIS University, Kolkata - 700109, India.
2School of Pharmacy, Adamas University, Barasat, Kolkata.
*Corresponding Author

Published In:   Volume - 16,      Issue - 7,     Year - 2023


ABSTRACT:
The aim of the present research is to study the potential pharmacological activities of herbal extract of Ziziphus and its formulations. It is observed that the plant extracts of different species of Ziziphus have a variety of pharmacological activities. Due to antibiotic resistance, it is necessary to discover new sources of antibiotics. New technologies are used for the development of antimicrobial and antioxidant drugs with enhanced pharmacological activities. Also, scientists are concentrating on herbal medicines because of their numerous advantages over synthetic drugs. Now-a-days many of these herbal formulations, sold over the counter, are not properly standardized for quality and toxicity. In this research work the sub-chronic dermal toxicity study of Ziziphus oenoplia leaf extract containing Carbopol hydrogel formulation is evaluated on adult male Albino Wister rats. Here, the extract containing hydrogel in 3 doses, and 0.9% NaCl solution (negative control) has been applied on the shaved area of dorsolateral trunk of different groups of rats once a day for 28 days for the study. After conduction of the experiment, it has been observed that the control as well as the test groups of animals did not possess any mortality/ morbidity, clinical signs of toxicity or skin reactions such as edema or erythema. There has been no significant change in food consumption or any notable elevation in body weight in the animal groups throughout the experimental period. Thus, in this study the Ziziphus extract incorporated Carbopol hydrogel has been successfully evaluated for dermal toxicity which reveals that the formulation can be safely applied dermally for wound healing purpose.


Cite this article:
Devlina Pal, Asim Halder, Dibya Das, Himangshu Sekhar Maji. Promising Pharmacological Activities of Ziziphus Herbal Extract and its Formulations. Research Journal of Pharmacy and Technology 2023; 16(7):3300-4. doi: 10.52711/0974-360X.2023.00544

Cite(Electronic):
Devlina Pal, Asim Halder, Dibya Das, Himangshu Sekhar Maji. Promising Pharmacological Activities of Ziziphus Herbal Extract and its Formulations. Research Journal of Pharmacy and Technology 2023; 16(7):3300-4. doi: 10.52711/0974-360X.2023.00544   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-41


REFERENCES:
1.    Sukmandari NS, Dash GK, Jusof WWH, Hanafi M, A Review on Nephelium lappaceum L. Res J Pharm Technol.  2007. 10(8), 1-9. DOI: 10.5958/0974-360X.2017.00498.X
2.    Raghvendra D, Dubey K, Sridhar C, Jayaveera KN, Human vaginal pathogen inhibition studies on aqueous, methanolic and saponins extracts of stem barks of Ziziphus mauritiana. Int.J. Pharm. Sci. Res. 2011. 2(3), 659-663.DOI: 10.13040/IJPSR.0975-8232.2(3)
3.    Maaiden EE, Kharrassi YE, Qarah NAS, Essamadi AK, Moustaid K, Nasser B, Genus Ziziphus: A Comprehensive review on ethnopharmacological, phytochemical and pharmacological properties, J. Ethnopharmacol. 2019. S0378-8741(19), 33861-861. DOI: https://doi.org/10.1016/j.jep.2020.112950
4.    Soares GMS, Figueiredo LC, Faveri M, Cortelli SC, Duarte PM, Feres M, Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs. J Appl Oral Sci. 2012. 20(3), 295-309. DOI: 10.1590/s1678-77572012000300002
5.    Sreeja MK, Gowrishankar NL, Adisha S, Divya KC, Antibiotic resistance-reasons and the most common resistant pathogens - A review. Res J Pharm Technol. 2017. 10(6), 1886 -90.  DOI: 10.5958/0974-360X.2017.00331.6
6.    Gupta PD, Birdi TJ, Development of botanicals to combat antibiotic resistance. J Ayurveda Integr Med. 2017. 8(4), 266-75. DOI: 10.1016/j.jaim.2017.05.004
7.    Prithviraj C, Suresh K, Debarupa D , Gupta Vikas, Role of Antioxidants in Common Health Diseases. Res J Pharm Technol. 2009. 2(2), 234-44.
8.    Khe JC, Shivkanya F, Vetriselvan S, Mahendran S, Kathiresan V. S, Saminathan K, Seng WY, Raju VVSS, Kumar JA, Hasan MMN, Kumar FN, Phytochemical screening and antioxidant activity of cananga odorata extract. Res J Pharm Technol. 2022. 15(3), 1230-34. DOI : 10.52711/0974-360X.2022.00205
9.    Pallab K, Satyendra D, Kanta SR,. A review on ethanolic plants of Assam (India) and their Anti-oxidant activity. J. Med Pharm Allied Sci. 2014. 6(3), 20-28.
10.    Mathew S, Abraham TE, Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chem. 2006. 94(2006), 520-28. DOI: 10.1016/j.foodchem.2004.11.043
11.    Saraf AS, Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010. 81 (2010), 680–689. DOI: 10.1016/j.fitote.2010.05.001
12.    Gavan A, Colobatiu L, Hanganu D, Bogdan C, Olah NK, Achim M, Mirel S, Development and Evaluation of Hydrogel Wound Dressings Loaded with Herbal Extracts. Processes. 2022. 10(242): 1-12. DOI: org/10.3390/pr10020242
13.    Sawant SV, Sankpal SV, Jadhav KR, Kadam VJ. Hydrogel as drug delivery system. Res J Pharm Technol. 2012, 5(5), 561-569.
14.    Gharat JS, Dalvi YV, Compressive Review on Hydrogel. Res. J. Pharm Technol. 2018. 8(3), 172-181. DOI: 10.5958/2231- 5713.2018.00028.4
15.    Fathi M, Ahmadi N, Forouhar A, Atani SH. Natural Hydrogels, the interesting carriers for herbal extracts. Food Rev. Int. 2021. Feb,1-25. DOI: .org/10.1080/87559129.2021.1885436
16.    Vitale S, Colanero S, Placidi M, Emidio GD, Tatone C, Amicarelli F, D’Alessandro AM, Phytochemistry and biological activity of medicinal plants in wound healing: An overview of current research. Molecules. 2022. 27(3566), 1-30. DOI: 10.3390/molecules27113566
17.    Mishra AK, Mishra A, Chattopadhyay P. Screening of acute and sub-chronic dermal toxicity of Calendula officinalis L essential oil. Regul. Toxicol. Pharmacol. 2018, 98(2018). 184-189. DOI: 10.1016/j.yrtph.2018.07.027
18.    Bukar AM, Kyari MZ, Gwaski PA, Gudusu M, Kuburi FS, Abadam YI, Evaluation of phytochemical and potential    antibacterial activity of Ziziphus spinachristi L. against some medically important pathogenic bacteria obtained from University of Maiduguri Teaching Hospital, Maiduguri, Borno State - Nigeria. J. pharmacogn. Phytochem. 2015. 3(5), 98-101.
19.    Aggarwal B, Sharma P, Lamba HS, Assessment of Phytochemical and in vitroAntioxidant Potential of Zizyphus nummularia Stem Bark. Int J Pharma Res Health Sci. 2018. 6(2), 2502-06. DOI:10.21276/ijprhs.2018. 2018. 02.29
20.    Jena BK, Ratha B, Kar S, Mohanta S,Tripathy M, Nayak AK, Wound healing potential of Ziziphus xylopyrus WILLD. (Rhamnaceae) stem bark ethanol extract using in vitro and in vivo model. J. Drug Deliv.Ther. 2012. 2(6), 41-46.
21.    Rocchetti G, Alcántara C, Bäuerl C, García-Pérez JV, José, Lorenzo JM, Lucini L, Collado MC, Barba FJ, Bacterial growth and biological properties of Cymbopogon schoenanthus and Ziziphus lotus are modulated by extractionconditions. Food Res. 2020. 136(109534), 1-10. DOI: 10.1016/j.foodres.2020.109534
22.    Manjunatha E, Vedigounder M, Geetha KM, Nandeesh R, Ahmed SM, Antioxidant and Antiulcer activity of Ziziphus rugosa Lam. Bark. Res J Pharm. Technol. 2020. 13(10), 4720-4724. DOI: 10.5958/0974-360X.2020.00831.8
23.    Abdallah EM, Elsharkawy ER, Ed-dra A, Biological activities of\methanolic leaf extract of Ziziphus mauritiana. Biosci. Biotech. Res. Comm. 2016. 9(4), 605-14.
24.    Afzal S, Batool M, Ahmad Ch BA, Ahmad A, Uzair M,Afzal K, Immunomodulatory, Cytotoxicity, and AntioxidantActivities of Roots of Ziziphus mauritiana,. Pharmacogn. Mag. 2017. 13 (50), S262–S265. DOI: 10.4103/pm.pm_398_16
25.    Soman S, Ray JG, Silver nanoparticles synthesized using aqueous leaf extract of Ziziphus oenoplia (L.) Mill: Characterization and assessment of antibacterial activity. J. Photochem. Photobiol. B, Biol. 20016. 163(2016), 391-402. DOI: 10.1016/j.jphotobiol.2016.08.033
26.    Asimuddin M, Shaik M R, Fathima N, Afreen MS, Adil SF, Siddiqui MRH, Jamil K, Khan M, Study of Antibacterial Properties of Ziziphus mauritiana based Green Synthesized Silver Nanoparticles against Various Bacterial Stains. Sustainability. 2020. 12(1484), 1-14. DOI: 10.3390/su12041484
27.    Amdelkar H, Alzahrani H, Al-Ayafi A, Al-Mulah H, Al-Zubaidi S, Green Synthesis, Characterization and Antimicrobial Activity of Biosynthesized Silver Nanoparticles using Ziziphus spina- cristi Leaf Extracrs. HSOA Adv in MicrobioResearch., 2019. 3(010), 1-7. DOI: 10.24966/AMR-694X/100010
28.    Padalia H, Chanda S, Antioxidant and Anticancer Activities of Gold Nanoparticles Synthesized Using Aqueous Leaf Extract of Ziziphus nummularia. BioNanoScience. 2021, 281-294. DOI:10.1007/s12668-021-00849-y
29.    Sobhani Z, Emami SA, Bazzaz BSF, Rajabi O, A modern formulation of traditional medicine: Jujube (Ziziphus jujuba Mill.) fruit syrup. Indian J. Tradit. Knowl. 2019. 18(4),662-669.
30.    Akhtar N, Ijaz S, Khan HMS, Uzair B, Reich A, Khan BA, Ziziphus mauritiana leaf extract emulsion for skin rejuvenation. Trop. J. Pharm. Res. 2016. 15(5), 929-936. DOI: 10.4314/tjpr.v15i5.5
31.    Hamedi S, Shams-Ardakani MR, Sadeghpour O, Amin G, Hajighasemali D, Orafai H, Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents. Iran J Basic Med Sci. 2016. 19(3), 330-336.
32.    Sekar M, Priya NV, Ramesh R, Kumar SG, Bharati AD, Afsha SA, Formulation and Evaluation of Hair Tonic from Ziziphus Jujuba Leaf Extract. Int. j. pharm. chem. biol. sci. 2016. 6(4), 447-454.
33.    Ali Y, Nada MR, Hameeda AN, Taghreed F, Salwa H, Inaam J, Furqan S, Ban S, Allelopathi Effect of the Leaf Extracts of Zizyphus spina-christi (Sedr), Salix fragilis L. and Ricinus communis L. on Seed Germination Percentage of Triticumaestivum L. in Iraq. Research J. Pharm. and Tech. 2018.11(1), 187-192. DOI: 10.5958/0974-360X.2018.00035.5
34.    Chirayath RB, Viswanathan AA, Jayakumar R, Biswas R, Vijayachandran LS, Development of Mangifera indica leaf extract incorporated carbopol hydrogel and its antibacterial efficacy against Staphylococcus aureus. Colloids Surf. B. 2019. 178(2019), 377–384. DOI: 10.1016/j.colsurfb.2019.03.034
35.    Haneefa KP M, Hanan K S, Saraswathi R, Mohanta GP, Nayar C, Formulation and evaluation of herbal gel of Pothos scandens Linn. Asian Pac. J. Trop. Med. 2010. Dec(2010), 988-992. DOI:10.1016/S1995-7645(11)60015-1
36.    Baidya M, Jayaraman A, Maji HS, Krishna P S R, Das D, Evaluation of acute and sub-acute toxicity of Sivanar amirtham in albino mice and wistar albino rats. J. med. pharm. allied sci. 2022. Jan-Feb; 11(1), 2217, 4196-4204. DOI:10.22270/jmpas.V11I1.2217
37.    Baidya M, Maji HS, Bhatt S, Das D. In-vitro evaluation of the thrombolytic and anti-inflammatory activity of Capparis sepiaria root extracts. J. med. pharm. allied sci. 2022. Jan-Feb; 11(1), 1879, 4166-4171. DOI:10.22270/jmpas.V11I1.1879



Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available