Author(s):
Shivam Bajpai, Sundaram Singh
Email(s):
sbajpai7@gmail.com
DOI:
KEYWORDS: Quinoxaline derivatives, Dalton’s lymphoma cells, Viability, Anti-cancer potential, Apoptosis. 
Address:
Shivam Bajpai1*, Sundaram Singh2
1Department of Chemistry, Bipin Bihari College, Affiliated To Bundelkhand University, Jhansi- 284001, U.P., India.
2Department of Chemistry, Indian Institute of Technology, Banaras Hindu University, Varanasi – 221 005, U.P., India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
ABSTRACT:
Indole based quinoxaline derivatives (2a-f) were synthesized and the therapeutic potential of the synthesized compounds (2a-f) was investigated against Dalton’s Lymphoma (DL) cells. It was observed that treatment of DL cells with quinoxaline derivatives (2a-f) showed significant decrease in cell viability, altered morphology, nuclear disintegration and DNA fragmentation into low molecular weight DNA fragments and thus characteristic of apoptosis. In this view, the synthesized compounds may be used as potential therapeutic regimen to treat this type of cancer.
Cite this article:
Shivam Bajpai, Sundaram Singh. Anti Cancer Potential of some Indole based Quinoxaline Derivatives against Dalton’s Lymphoma (DL) cells. Research Journal of Pharmacy and Technology 2023; 16(7):3165-1. doi: KEYWORDS: Quinoxaline derivatives, Dalton’s lymphoma cells, Viability, Anti-cancer potential, Apoptosis.
Cite(Electronic):
Shivam Bajpai, Sundaram Singh. Anti Cancer Potential of some Indole based Quinoxaline Derivatives against Dalton’s Lymphoma (DL) cells. Research Journal of Pharmacy and Technology 2023; 16(7):3165-1. doi: KEYWORDS: Quinoxaline derivatives, Dalton’s lymphoma cells, Viability, Anti-cancer potential, Apoptosis. Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-17
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