Author(s): Gade Kalyani, Azka Fathima, Guddeti Venkateswarlu, D. Ravi Sankar Reddy, Shaik Harun Rasheed

Email(s): gadekalyani1989@gmail.com

DOI: 10.52711/0974-360X.2023.00515   

Address: Gade Kalyani1*, Azka Fathima2, Guddeti Venkateswarlu3, D. Ravi Sankar Reddy4, Shaik Harun Rasheed5
1Associate Professor, Department of Pharmacology, Bharat Institute of Technology, Mangalpally, Ibrahimpatnam - 501510, Telangana, India.
2Assistant Professor, Department of Pharmaceutical Analysis, Bharat Institute of Technology, Mangalpally, Ibrahimpatnam - 501510, India.
3Assistant Professor, Department of Pharmacology, School of Pharmacy, Guru Nanak Campus, Ibrahimpatnam - 501506, Telangana, India.
4Professor, Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India - 522510.
5Professor, Department of Pharmacy, School of Pharmacy, Guru Nanak Campus, Ibrahimpatnam - 501506, Telangana, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 7,     Year - 2023


ABSTRACT:
The present study is intended to evaluate and analyze in-vitro antibacterial and antioxidative activities of leaf extracts of Melia azedarach Linn (M. azedarach L.) and Psidium guajava Linn (P. guajava L.). In-vitro antibacterial activity was measured using agar well diffusion assay against Pseudomonas aeruginosa and Staphylococcus aureus strains. In-vitro antioxidant activity was estimated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Among both plants high minimum inhibitory concentration values are observed with P. guajava L. ethanol extract at 47.6µg/ml for S. aureus and 43.7µg/ml for P. aeruginosa, respectively. The results revealed that 20µg/ml ethanol extracts of P. guajava L. exhibited the highest radical % scavenging activity (76.24%) succeeded by methanol extracts (72.78%), respectively indicating they are effective solvents to extract phenolic compounds. We demonstrated that for both bacterial strains, ethanol followed by methanol extracts showed significant antibacterial activity in P. guajava L.in dose dependent manner indicating the presence of high flavonoids, tannins, and steroids. Our results revealed that both plants are vital reservoirs of phytochemicals with both antibacterial and antioxidant capacities.


Cite this article:
Gade Kalyani, Azka Fathima, Guddeti Venkateswarlu, D. Ravi Sankar Reddy, Shaik Harun Rasheed. Evaluation of Antibacterial and Antioxidant potential of Melia. Azedarach linn. and Psidium guajava linn. Leaf extracts. Research Journal of Pharmacy and Technology 2023; 16(7):3132-8. doi: 10.52711/0974-360X.2023.00515

Cite(Electronic):
Gade Kalyani, Azka Fathima, Guddeti Venkateswarlu, D. Ravi Sankar Reddy, Shaik Harun Rasheed. Evaluation of Antibacterial and Antioxidant potential of Melia. Azedarach linn. and Psidium guajava linn. Leaf extracts. Research Journal of Pharmacy and Technology 2023; 16(7):3132-8. doi: 10.52711/0974-360X.2023.00515   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-7-12


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