Author(s):
Bayu Eko Prasetyo, Norazrina Azmi, Lia Laila, Ahmad Fuad Shamsuddin
Email(s):
fuad.shamsuddin@unikl.edu.my , bayu@usu.ac.id
DOI:
10.52711/0974-360X.2023.00430 
Address:
Bayu Eko Prasetyo1,2, Norazrina Azmi3, Lia Laila1,2, Ahmad Fuad Shamsuddin4*
1Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia.
2Nanomedicine Center of Innovation, Universitas Sumatera Utara, Medan, 20155, Indonesia.
3Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
4Faculty of Pharmacy and Health Sciences, University Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), No. 3 Jalan Greentown 30450 Ipoh, Perak, Malaysia.
*Corresponding Author
Published In:
Volume - 16,
Issue - 6,
Year - 2023
ABSTRACT:
HPLC is one of the methods that is widely used for the routine determination of drug content in a pharmaceutical dosage form. The objective on this research was to develop a simple method to determine the propofol concentration in a new formulation using a palm oil-based nanoemulsion carrier system (NEMS™ MCT/LCT). The method used was reverse phase high performance liquid chromatography (RP-HPLC) using a C18 column with methanol and water (80:20) as the mobile phase and UV wavelength detection was 276 nm. The retention time obtained for the drug in NEMS MCT/LCT was 6.32 min. This was similar to the retention time of the standard. The correlation coefficient value from the calibration curve was 0.9998. The drug contents were 100.90% and 100.24% for the 1% and 2% NEMS MCT/LCT, respectively. The result indicated that the RP-HPLC method used for the analysis of propofol in the palm oil-based emulsion system was able to accurately determine the concentration of the drug.This method is suitable for routine determination of propofol concentration in palm oil-based emulsion formulations.
Cite this article:
Bayu Eko Prasetyo, Norazrina Azmi, Lia Laila, Ahmad Fuad Shamsuddin. Propofol Quantification method in Palm Oil Based Nanoemulsion Formula using RP-HPLC. Research Journal of Pharmacy and Technology 2023; 16(6):2622-2626. doi: 10.52711/0974-360X.2023.00430
Cite(Electronic):
Bayu Eko Prasetyo, Norazrina Azmi, Lia Laila, Ahmad Fuad Shamsuddin. Propofol Quantification method in Palm Oil Based Nanoemulsion Formula using RP-HPLC. Research Journal of Pharmacy and Technology 2023; 16(6):2622-2626. doi: 10.52711/0974-360X.2023.00430 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-6-8
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