ABSTRACT:
The investigation of heavy metals in herbal products is widely interesting in many countries over the world (China, India, Turkey, Poland, Germany, Australia etc.), where the herbal products have been used as “scientific medicines”. The heavy metal content of medicinal herb products is commonly studied from the viewpoint of toxicity and bioavailability. Heavy metals can be hazardous to human and animal health and thus their content in plants used for consumption or medicinal purposes must be limited and checked. For this reason upper limits for heavy metals have been set for foodstuffs and medicinal products by health authorities. In general, all medicinal products for human and animal use must meet regulatory guidelines for quality, safety, and efficacy. Heavy metal analysis of the extracts of leaves ofAegle marmelos (L.)Correa, Cynodon dactylon (L.) Pers., Annona squamosa Linn, Moringa oleifera Lam. and other plant parts of Musa paradisiaca L. andPunicagranatum L. was undertaken. From the results of the study, it can be concluded that the extracts of the leaves and other plant parts of above mentioned medicinal plants showed no risk of heavy metal toxicity as most of the heavy metals analysed in these plant parts were well within the permissible levels, except for Cynodon dactylon (L.) Pers. which showed slightly higher levels of Chromium.
Cite this article:
S. M. Pawaskar, S. Khan. Heavy Metal Analysis of the leaf extracts of some Indian Medicinal Plants from Western Maharashtra. Research Journal of Pharmacy and Technology 2023; 16(6):2801-7. doi: 10.52711/0974-360X.2023.00461
Cite(Electronic):
S. M. Pawaskar, S. Khan. Heavy Metal Analysis of the leaf extracts of some Indian Medicinal Plants from Western Maharashtra. Research Journal of Pharmacy and Technology 2023; 16(6):2801-7. doi: 10.52711/0974-360X.2023.00461 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-6-39
REFERENCES:
1. M.J. Stewart, J.J. Moar, P. Steenkamp, M. Kokot. Findings in fatal cases of poisoning attributed to traditional remedies in South Africa, Forensic Science International. 1999;101:177-183. doi:10.1016/s0379-0738(99)00025-0
2. Edzard Ernst.Toxic heavy metals and undeclared drugs in Asian herbal medicines, Trends in Pharmacological Sciences. March 2002;23(3):136-139. doi: 10.1016/S0165-6147(00)01972-6
3. Olujohungbe, A., Fields, P.A., Sandford, A.F. Heavy metal intoxication from homeopathic and herbal remedies. Postgraduate Medical Journal.1994;70:764–769.doi: 10.1136/pgmj.70.828.764
4. Jones, J.B. and Case, V.W. Sampling.Handling and Analyzing Plant Tissue Samples. In: Westerman, R.L. (ed.). Soil Testing and Plant Analysis. 1990: 404–409.
5. FalusiBamideleAyodeji. Heavy metal contents of Azidirachta indica collected from Akungba-Akoko (Nigeria). African Journal of Health Sciences. 2010;17:3-4.doi:10.4314/AJHS.V17I3
6. McLaughlin, M.J., Parker, D.R., Clark, J.M. Metals and micronutrients - food safety issues. Field Crops Research. 60:143–163.doi:10.1016/S0378-4290(98)00137-3
7. T.Sheelarani, V. Gopal, S. Seethalakshmi, K. Chitra. Heavy Metal and Trace Element Analysis of Myxopyrumserratulum A.W. Hill. Research J. Pharm. and Tech. 8(9): Sept, 2015; Page 1197-1198.doi: 10.5958/0974-360X.2015.00218.8
8. Levitt, M.D. Sources of lead poisoning. Journal of the American Medical Association. 1984;252:3127–3128.doi: 10.1001/jama.1984.03350220035014
9. Chan, T.Y.K., Tomlinson, B., Critchley, A.J.H. Chinese herbal medicines revisited: a Hong Kong perspective. The Lancet.1993;342:1532–1534. Chan, T.Y.K., Tomlinson, B., Critchley, A.J.H. Chinese herbal medicines revisited: a Hong Kong perspective. The Lancet.1993.doi: 10.1016/s0140-6736(05)80091-1
10. Pip, E. Cadmium, Copper and Lead in soils and garden produce near a metal smelter at FlinFlon, Manitoba. Bulletin of Environmental Contamination and Toxicology. 1991;46:790–796.doi:10.1007/BF01689969
11. Abou-Arab, A.A.K., Kawther, M.S., El Tantawy, M.E., Badeaa, R.I., Khayria, N. Quantity estimation of some contaminants in commonly used medicinal plants in the Egyptian market. Food Chemistry. 1999;67:357–363.doi:10.1016/S0308-8146(99)00082-5
12. Samidha M. Pawaskar and K. C., Sasangan. Preliminary phytochemical and invitro-antioxidant and analysis of Moringa oleifera Lam. Leaf extract. International Journal of Recent Advances in Multidisciplinary Research. 2017;04(08):2733-2740.
13. Samidha M. Pawaskar and K. C. Sasangan. Biochemical and nutritional Analysis of the leaf extract of Aegle marmelos (L.) Correa. International Journal of Current Research and Review. 2017; 9, Issue 11.doi:http://dx.doi.org/10.7324/IJCRR.2017.9111
14. Qurratulane Bari, NagendraBhardwaj. Heavy metal analysis of woolen carpet industry effluent in Tonk (Rajasthan). Research J. Science and Tech 5(2): April- June, 2013 page 268-271.
15. L Zhou, D Yu, H Yu, K Chen, G F Shen, Y Z Shen, Y L Ruan, X F Ding.Drinking water types, microcystins and colorectal cancer, Chinese Journal of Preventive Medicine. 2000;34:33-35.doi:https://doi.org/10.1016/S2095-3119(15)61128-5.
16. Mohammad Rehan, Dhirendra Kumar Bharati, Sushmita Banerjee, Ravindra Kumar Gautam, Mahesh Chandra Chattopadhyaya. Physicochemical and Heavy Metal Analysis of Pond Water Quality of Mau-Aima Vicinity, Allahabad (India). Asian J. Research Chem. 2017; 10(1):29-32.doi:10.5958/0974-4150.2017.00005.0
17. USEPA, (2001). Proposed Revision to Arsenic Drinking Water Standard. (815-F-00-012), http://www.epa.gov/safewater/arsenic/regulations pro-factsheet.html.
18. Saranya A, NithyaS.Assessment of Heavy Metal Induced Organ Toxicity in marketed Ayurvedhic Formulation and Report its LD50 value with Brine Shrimp Lethality Assay. Research J. Pharm. and Tech. 2017; 10(1): 263-268. doi:10.5958/0974-360X.2017.00054.3
19. WHO, (2004). Guidelines on Developing Consumer Information on Proper Use of Traditional, Complementary and Alternative Medicine: Geneva, WHO.
20. McGrath, S. P.; Smith, S. Chromium and Nickel in Heavy Metals in Soils, Alloway, B. J., Ed.; Blackie: Glasgow. 1990;125-150.
21. Shaheen, D. G. Environ. Pot. Agency Report. 1975;EPA 600/2-75-004.
22. V. Bharani, S. Sathyaraj, Astha Sinha, D. Sugankumar, Osborne J. W. A Survey on the Accumulation of Chromium in Plants near Various Tannery Industries of Vellore District, T.N. Research J. Pharm. and Tech. 8(9):September, 2015; Page 1205-1208.doi:10.5958/0974-360X.2015.00217.6
23. R.H. Krishna Reddy, N. Naga MalleswaraRao, J. V. SumanKrishna , K. Ravindhranath. Extraction of Chromium (VI) from polluted waters using powders of leaves and their ashes of some herbal plants .Research J. Science and Tech. 2012; 4(2): 78-85 .
24. Khan Murad Ali, Ahmad Ijaz and Rahman.Inayatur. Effect of Environmental Pollution on Heavy Metals Content of Withaniasomnifera. Journal of the Chinese Chemical Society. 2007;54:339-343. doi: https://doi.org/10.1002/jccs.200700049
25. Nair, M., Balachandran, K.K., Sankarnarayan, V.N. and Joseph, T. Heavy metals in fishes from coastal waters of Cochin, South West Coast of India. Indian Journal of Marine Science. 1997;26:98-100.
26. Aiman Konkabayeva, Margarita Ishmuratova, Aleksandr Pudov, Rahat Bodeeva, Aidar Aitkulov, Gulmira Tykezhanova, Sayagul Tyrzhanova. Assessment of Neurotoxicity of Cultivated Plants Grown in the Neighborhood of Industrial Regions of Central Kazakhstan. Research J. Pharm. and Tech. 2017; 10(2): 562-566. doi:10.5958/0974-360X.2017.00112.3
27. T. Sivabalan, Kalpana Kale. Impact of Education Intervention on Awareness regarding Lead Poison among Parents Residing at Rural Maharashtra. Asian J. Nursing Education and Research. 2018; 8(4):511-514.doi:10.5958/2349-2996.2018.00104.0
28. Tong, S., von Schirnding, Y.E., Prapamontol, T. Environmental lead exposure: a public problem of global dimension. Bulletin of the World Health Organization. 2000;78:1068–1077. PMID: 11019456; PMCID: PMC2560844.
29. WHO, (October 2003). World Health Report – Shaping the future, Geneva, Switzerland.
30. S.K Bais, A.V. Chandewar , D.W. Wargantiwar, S.M. Charjan. Comparative Evaluation of Heavy Metals in Marketed Haematinic Herbal Formulations by Atomic Absorption Spectroscopy. Asian J. Pharm. Ana. 4(1): Jan.-Mar. 2014; Page 11-16.
31. WHO, (1998). Quality Control Methods for Medicinal Plant Materials, Office of Publications, England, pg. 8.
32. Neil, PO.Minor Element and Environmental Problems. Envir. Chem. 1993; 2nd ed.
33. Pavithra H Dav, Abilasha. R. Allergic Reactions and Nickel -Free Braces: A Review. Research J. Pharm. and Tech. 2016; 9(9):1516-1518. doi:10.5958/0974-360X.2016.00296.1
34. Davies, B. E. Cadmium in Heavy Metals in Soil, Alloway, B. J., Ed.; Blackie:Glasgow. 1990:100.
35. Godt, J., Scheidig F., Siestrup, C.G., Esche, V. ,Brandenburg,P., Reich, A., David, A. andGroneberg, D.A.The toxicity of cadmium and resulting hazards for human health. J. Occup. Med. Toxicol. 2006;22:1–6. doi:10.1186/1745-6673-1-22
36. Nordberg, G. Excursions of intake above ADI: case study on cadmium. Regulatory. Toxicology and Pharmacology.1999;30:S57–S62. doi:https://doi.org/10.1006/rtph.1999.1327.
37. Waalkes, M.P., S. Rehm, C.W. Riggs, R.M. Bare, D.E. Devor, L.A. Poirier, M.L. Wenk, J.R. Henneman and M.S. Balaschak. Cadmium carcinogenesis in male WistarCrl: (WI) BR rats: dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res.1988;48:4656–4663 PMID: 3396014
38. WHO.Guidelines for Medicinal Plants Quality. 1985;Vol.1. Recommendation WHO: Geneva.
39. Pharmeuropa. Herbal drugs, monograph -1433. 2008;20(2):302-303.
40. Sekabira, K., Oryem-Origa, H., Basamba, T.A., Mutumba, G., Kakudidi, E. Assessment of heavy metal pollution in the urban stream sediments and its tributaries. Int. J. Environ. Sci. Tech. 2010;7(3):435- 446.doi:10.1007/BF03326153
41. Bu-Olayan AH, Thomas BV. Translocation and bioaccumulation of trace metals in desert plants of Kuwait Governorates. Res. J. Environ. Sci. 2009;3(5): 581-58.doi:10.3923/rjes.2009.581.587
42. Ayari F, Hamdi H, Jedidi N, Gharbi N, KossaiR.Heavy metal distribution in soil and wheat plants in municipal solid waste compostamended plots. Int. J. Environ. Sci. Tech.2010;7(3):465-472.
43. Sharma, Abhishek L., ShailajanSunita, (2009). Detection of heavy metals from leaf powders of Annona squamosa Linn.,Daturametel Linn. andVitexnegundo Linn. using ICP- OES technique. Environmental Science Journal. 2010;4:1- 4.
44. Subramanian, R., Gayathri, S., Rathnavel, C., Raj, V. Analysis of mineral and heavy metal levels nutrients in medicinal plants collected from local market. Asian Pacific Journal of Tropical Biomedicine. 2011;17:829.doi:https://doi.org/10.1016/S2221-1691(12)60133-6.
45. Seyed Esmael Mahdavian, R.K. Somashekar, Heavy metals and safety of fresh fruits in bangalore city, India – a case study, Kathmandu University Journal of Science, Engineering and Technology. 2008;5:17-27.
46. Abou-Shanab R, Ghanem N, Ghanem K, Al-Kolaibe A. Phytoremediation potential of crop and wild plants for multi-metal contaminated soils. Res. J. Agric. Biol. Sci. 2007;3(5):370-376
47. Muwanga, A., Barifaijo, E. Impact of industrial activities on heavy metal loading and their physico-chemical effects on wetlands of Lake Victoria basin (Uganda). Afr. J. Tech. Sci. Eng. 2006;7(1): 51-63. doi:10.4314/ajst.v7i1.55197
48. Toxicological profile for Cadmium U.S.Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry (ATSDR), September 2012