Author(s): Mst. Mahfuza Rahman, Md. Kouser, Uthpall Kumar Roy, Shahriar Mohammad Shohan, Md. Jahirul Islam, Mst. Shagorika Shila, Sangita Chakraborty, Mir Imam Ibne Wahed

Email(s): mahfuzarahman49@gmail.com

DOI: 10.52711/0974-360X.2023.00411   

Address: Mst. Mahfuza Rahman1*, Md. Kouser1, Uthpall Kumar Roy1, Shahriar Mohammad Shohan1, Md. Jahirul Islam1, Mst. Shagorika Shila1, Sangita Chakraborty1, Mir Imam Ibne Wahed2
1Department of Pharmacy, Comilla University, Koatbari, Cumilla - 3506, Bangladesh.
2Department of Pharmacy, University of Rajshahi, Rajshahi - 6205, Bangladesh.
*Corresponding Author

Published In:   Volume - 16,      Issue - 5,     Year - 2023


ABSTRACT:
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health hazard that has been classified as a pandemic by the World Health Organization (WHO). The task of developing efficient prevention and treatment measures for this pandemic is unparalleled. Due to nano-material's unique physicochemical features and controlled nano-bio interactions, nanotechnology has demonstrated significant potential in its capacity to combat a number of healthcare conditions. The application of nanotechnology for COVID-19 has been discussed in depth in this systematic review, which is divided into three sections: prevention, diagnostics, and treatment. To begin, we focused on nanotechnology-based protective equipment and disinfectants that can give much-needed protection against SARS-CoV-2. Again, nanoparticles can be used as an antigen carrier or adjuvant, paving the path for the development of a number of vaccines with preventive benefits. The capacity of nano-materials to magnify signal is then highlighted, which has been employed in the development of nano-biosensors and nano-imaging techniques that can be used for early-stage detection in conjunction with other diagnostic instruments. Finally, we discuss COVID-19 therapeutic approaches based on nano-materials. Nano-metals and their oxides affect cellular processes by interfering with the production of reactive oxygen species (ROS), which then give antiviral action. Various nano-products (polyethylenimine, squalene) can significantly lower the synthesis of inflammatory modulators (Cytokine storm), hence preventing Covid-19 infection. The review's limitations and nanoparticle's future directions for COVID-19 have been described briefly. This review is quite comprehensive and useful in terms of providing suggestions for developing nanomaterial-based devices to combat against COVID-19.


Cite this article:
Mst. Mahfuza Rahman, Md. Kouser, Uthpall Kumar Roy, Shahriar Mohammad Shohan, Md. Jahirul Islam, Mst. Shagorika Shila, Sangita Chakraborty, Mir Imam Ibne Wahed. The Significance and Implications of Nanotechnology in COVID-19. Research Journal of Pharmacy and Technology 2023; 16(5):2409-6. doi: 10.52711/0974-360X.2023.00411

Cite(Electronic):
Mst. Mahfuza Rahman, Md. Kouser, Uthpall Kumar Roy, Shahriar Mohammad Shohan, Md. Jahirul Islam, Mst. Shagorika Shila, Sangita Chakraborty, Mir Imam Ibne Wahed. The Significance and Implications of Nanotechnology in COVID-19. Research Journal of Pharmacy and Technology 2023; 16(5):2409-6. doi: 10.52711/0974-360X.2023.00411   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-70


REFERENCES:
1.    Talele SG, Ahire ED, Surana KR, Sonawane VN, Talele GS. Corona Virus Disease (COVID-19): A past and Present Prospective. Asian Journal of Pharmaceutical Research. 2022 Mar 5;12(1):45-53.
2.    Vishnu KN, Uppala PK, Vangoori Y, Gudhanti SN. A Review on Covid 19 Pandemic and its Global Effects. Asian Journal of Pharmaceutical Research. 2021 Dec 1;11(4).
3.    Cevik M, Kuppalli K, Kindrachuk J, et al. Virology, transmission, and pathogenesis of SARS-CoV-2. BMJ. 2020; 371: m3862.https://doi.org/10.1136/bmj.m3862
4.    Naresh BV. A review of the 2019 novel coronavirus (covid-19) pandemic. Asian Journal of Pharmaceutical Research. 2020;10(3):233-8.
5.    Hamid S, Mir MY, Rohela GK, et al. Novel coronavirus disease (COVID-19): a pandemic (epidemiology, pathogenesis and potential therapeutics). New Microbes and New Infections. 2020; 35: 100679. https://doi.org/10.1016/j.nmni.2020.100679
6.    Negi R, Saharan K, Pillai K. Knowledge regarding Immunity Boosting Measures for Self-care during COVID-19 crisis: Survey of Urban Community in Haryana. Asian Journal of Nursing Education and Research. 2021 Oct 1;11(4):488-94.
7.    GeurtsvanKessel CH, Okba N, Igloi Z, et al. An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nature Communications. 2020; 11(1): 1-5. https://doi.org/10.1038/s41467-020-17317-y
8.    Yadav AR, Mohite SK. A Novel approach for treatment of COVID-19 with Convalescent plasma. Research Journal of Pharmaceutical Dosage Forms and Technology. 2020;12(3):227-30.
9.    Choi JR. Development of point-of-care biosensors for COVID-19. Frontiers in Chemistry 2020; 8: 517. https://doi.org/10.3389/fchem.2020.00517
10.    Pirouz B, Arcuri N, Pirouz B, et al. Development of an assessment method for evaluation of sustainable factories. Sustainability. 2020; 12(5): 1841. https://doi.org/10.3390/su12051841
11.    Saudagar RB, Kanchan TM. A review on gold nanoparticles. Asian J. Pharm. Res. 2016 Jan;6(1):45-8.
12.    Khan Y, Gupta P, Bihari B, Sharma VK, Aziz I. A Review-Miracle of Nanotechnology in Cosmetics. Research Journal of Topical and Cosmetic Sciences. 2014;5(1):15-22.
13.    Sharma S, Kundu A, Basu S, et al. Indians vs. COVID-19: The scenario of mental health. Sensors International. 2020; 1: 100038.https://doi.org/10.1016/j.sintl.2020.100038
14.    Borse V, Konwar AN, Buragohain P. Oral cancer diagnosis and perspectives in India. Sensors International. 2020; 1: 100046. https://doi.org/10.1016/j.sintl.2020.100046
15.    R&D Blueprint and COVID-19. World Health Organization. 2020. http://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus/en/. Accessed  13 March 2020.
16.    Arabi YM, Asiri AY, Assiri AM, et al. Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial. Trials. 2020;21(1):1-8. https://doi.org/10.1186/s13063-019-3846-x
17.    Tian S, Hu W, Niu L, et al. Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer. Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer. 2020; 15(5): 700–704. https://doi.org/10.1016/j.jtho.2020.02.010
18.    Ghosh S, Bomma S, Prasanna VL, Srivani P, Bhanji D. New Analytical Methods in Nanotechnology-A Review. Asian Journal of Research in Pharmaceutical Science. 2013;3(1):31-41.
19.    Rangayasami A, Kannan K, Murugesan S, et al. Influence of nanotechnology to combat against COVID-19 for global health emergency: A review. Sensors International. 2021; 2: 100079. https://doi.org/10.1016/j.sintl.2020.100079
20.    Sivasankarapillai VS, Pillai AM, Rahdar A, et al.  On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First Challenges. Nanomaterials. 2020; 10(5): 852. https://doi.org/10.3390/nano10050852
21.    Carvalho APA, Conte‐Junior CA. Recent advances on nanomaterials to COVID‐19 management: a systematic review on antiviral/virucidal agents and mechanisms of SARS‐CoV‐2 inhibition/inactivation. Global Challenges. 2021; 5(5): 2000115. https://doi.org/10.1002/gch2.202000115
22.    Nikam A, Patil A, Magdum C. Overview and its application. Asian Journal of Pharmacy and Technology. 2021 Dec 1;11(4).
23.    Khurana A, Allawadhi P, Khurana I, et al. Role of nanotechnology behind the success of mRNA vaccines for COVID-19. Nano Today. 2021; 38: 101142.
24.    Abdelhamid HN, Badr G. Nanobiotechnology as a platform for the diagnosis of COVID-19: a review. Nanotechnology for Environmental Engineering. 2021; 6(1): 1-26. https://doi.org/10.1007/s41204-021-00109-0
25.    Bhalla N, Pan Y, Yang Z, et al. Opportunities and challenges for biosensors and nanoscale analytical tools for pandemics: COVID-19. ACS Nano. 2020; 14(7): 7783-7807. https://doi.org/10.1021/acsnano.0c04421
26.    Srivastava M, Srivastava N, Mishra PK, et al. Prospects of nanomaterials-enabled biosensors for COVID-19 detection. Science of The Total Environment. 2021; 754: 142363. https://doi.org/10.1016/j.scitotenv.2020.142363
27.    Milane L, Amiji M. Clinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicine. Drug Delivery and Translational Research. 2021; 11(4): 1309-1315.
28.    Bhattacharjee S, Joshi R, Chughtai AA, et al. Graphene modified multifunctional personal protective clothing. Advanced Materials Interfaces. 2019; 6(21): 1900622. https://doi.org/10.1002/admi.201900622
29.    Chaudhary V, Royal A, Chavali M, et al. Advancements in research and development to combat COVID-19 using nanotechnology. Nanotechnology for Environmental Engineering. 2021; 6(1): 1-15. https://doi.org/10.1007/s41204-021-00102-7
30.    Talebian S, Wallace GG, Schroeder A, et al. Nanotechnology-based disinfectants and sensors for SARS-CoV-2. Nature Nanotechnology. 2020; 15(8): 618-621. https://doi.org/10.1038/s41565-020-0751-0
31.    Aydemir D, Ulusu NN. Correspondence: Angiotensin-converting enzyme 2 coated nanoparticles containing respiratory masks, chewing gums and nasal filters may be used for protection against COVID-19 infection. Travel Medicine and Infectious Disease. 2020; 37: 101697. https://doi.org/10.1016/j.tmaid.2020.101697
32.    Imai Y, Kuba K, Rao S, et al.  Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005; 436(7047): 112–116. https://doi.org/10.1038/nature03712
33.    Aydemir D, Gecili F, Özdemir N, et al. Synthesis and characterization of a triple enzyme-inorganic hybrid nanoflower (TrpE@ihNF) as a combination of three pancreatic digestive enzymes amylase, protease and lipase. Journal of Bioscience and Bioengineering. 2020; 129(6): 679–686. https://doi.org/10.1016/j.jbiosc.2020.01.008
34.    Shirvanimoghaddam K, Akbari MK, Yadav R, et al.  Fight against COVID-19: The case of antiviral surfaces. APL Materials. 2021; 9(3): 031112. https://doi.org/10.1063/5.0043009
35.    Erkoc P, Ulucan-Karnak F. Nanotechnology-Based Antimicrobial and Antiviral Surface Coating Strategies. Prosthesis. 2021; 3(1): 25–52. https://doi.org/10.3390/prosthesis3010005
36.    Ahmad S, Zamry AA, Tan HTT, et al. Targeting dendritic cells through gold nanoparticles: A review on the cellular uptake and subsequent immunological properties. Molecular Immunology. 2017; 91: 123–133. https://doi.org/10.1016/j.molimm.2017.09.001
37.    Hofmann H, Hattermann K, Marzi A, et al. S Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Mediates Entry into Hepatoma Cell Lines and Is Targeted by Neutralizing Antibodies in Infected Patients. Journal of Virology. 2004; 78(12): 6134–6142. https://doi.org/10.1128/jvi.78.12.6134-6142.2004
38.    Kim YS, Son A, Kim J, et al. Chaperna-mediated assembly of ferritin-based Middle East respiratory syndrome-coronavirus nanoparticles. Frontiers in Immunology. 2018; 9: 1093.https://doi.org/10.3389/fimmu.2018.01093
39.    Jung S-Y, Kang KW, Lee E-Y, et al. Heterologous prime–boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus. Vaccine. 2018; 36(24): 3468–3476. https://doi.org/10.1016/j.vaccine.2018.04.082
40.    Shan B, Broza YY, Li W, et al. Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath. ACS Nano. 2020; 14(9): 12125-12132.https://doi.org/10.1021/acsnano.0c05657
41.    Kumar R, Jha AK, Jain SK. Nanomedicine: An Emerging Area of Nanotechnology. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009;1(1):18-21.
42.    Asif M, Ajmal M, Ashraf G, et al. The role of biosensors in coronavirus disease-2019 outbreak. Current Opinion in Electrochemistry. 2020; 23: 174–184. https://doi.org/10.1016/j.coelec.2020.08.011
43.    Seo G, Lee G, Kim MJ, et al. Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor. ACS Nano. 2020; 14(4): 5135–5142. https://doi.org/10.1021/acsnano.0c02823
44.    Kerry RG, Malik S, Redda YT, et al. Nano-based approach to combat emerging viral (NIPAH virus) infection. Nanomedicine: Nanotechnology, Biology and Medicine. 2019; 18: 196–220. https://doi.org/10.1016/j.nano.2019.03.004
45.    Shi X, Sun K, Baker JR. Spontaneous Formation of Functionalized Dendrimer-Stabilized Gold Nanoparticles. The Journal of Physical Chemistry C. 2008; 112(22): 8251–8258. https://doi.org/10.1021/jp801293a
46.    Fung SY, Yuen KS, Ye ZW, et al. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerging Microbes & Infections. 2020; 9(1), 558-570.https://doi.org/10.1080/22221751.2020.1736644
47.    Akbari A, Rezaie J. Potential therapeutic application of mesenchymal stem cell-derived exosomes in SARS-CoV-2 pneumonia. Stem Cell Research & Therapy. 2020; 11(1): 1-10.
48.    Behbudi G. Effect of silver nanoparticles disinfectant on covid-19. Advances in Applied NanoBio-Technologies. 2021; 2(2): 63-67.
49.    Ghaffari H, Tavakoli A, Moradi A, et al. Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine. Journal of Biomedical Science. 2019; 26(1): 1-10. https://doi.org/10.1186/s12929-019-0563-4
50.    Loutfy SA, Elberry MH, Farroh KY, et al. Antiviral Activity of Chitosan Nanoparticles Encapsulating Curcumin Against Hepatitis C Virus Genotype 4a in Human Hepatoma Cell Lines. International Journal of Nanomedicine. 2020; 15: 2699–2715. https://doi.org/10.2147/ijn.s241702
51.    Khurana A, Tekula S, Godugu C. Nanoceria suppresses multiple low doses of streptozotocin-induced Type 1 diabetes by inhibition of Nrf2/NF-κB pathway and reduction of apoptosis. Nanomedicine. 2018; 13(15): 1905–1922. https://doi.org/10.2217/nnm-2018-0085
52.    Campos EVR, Pereira AES, de Oliveira JL, et al. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. Journal of Nanobiotechnology. 2020; 18(1): 1-23. https://doi.org/10.1186/s12951-020-00685-4



Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available