Author(s):
Nina Nikolaevna Gavrilova, Irina Alexandrovna Ratnikova, Amankeldi Kurbanovich Sadanov, Saltanat Emilievna Orasymbet, Yerik Zharylkasynovich Shorabaev, Raushan Zhumabekovna Kaptagai
Email(s):
iratnikova@list.ru
DOI:
10.52711/0974-360X.2023.00400 
Address:
Nina Nikolaevna Gavrilova1, Irina Alexandrovna Ratnikova1*, Amankeldi Kurbanovich Sadanov2, Saltanat Emilievna Orasymbet1, Yerik Zharylkasynovich Shorabaev3, Raushan Zhumabekovna Kaptagai1
1Laboratory of Microbial Preparations, LLP "Research and Production Center for Microbiology and Virology", 105 Bogenbay Batyr Str., Almaty, 050010, Republic of Kazakhstan.
2LLP "Research and Production Center for Microbiology and Virology", 105 Bogenbay Batyr Str., Almaty, 050010, Republic of Kazakhstan.
3LLP "Industrial Microbiology", 89/44 Al-Farabi str., Almaty, 050060, Republic of Kazakhstan.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
The study aimed to create associations of probiotic bacteria with a wide range of biological activity, resistance to antibiotics, and selection of the nutrient medium composition to increase the effectiveness of probiotics against intestinal infections in humans. The authors found that the tested associations of probiotic bacteria exhibited sufficient antagonistic activity to all test cultures taken in the experiment. Associations No. 2 on media 1 and 4, No. 5 on media 1 and 8, and association No. 9 on media 1 and 8 showed the greatest activity for most test cultures. These associations have a bacterial titer of nx1010colony-forming units/ml, contain proteolytic, amylolytic, and pectolytic enzymes, as well as B vitamins, such as B3, B5, B6, B8, and B12. The authors studied the resistance of selected associations of lactic acid and propionic acid bacteria to the antibiotics used, which allows these associations to be used in complex therapy if necessary. Selected nutrient media and active associations of probiotic bacteria with a wide range of biological activity and antibiotic resistance can be used to create effective targeted medicinal probiotic agents.
Cite this article:
Nina Nikolaevna Gavrilova, Irina Alexandrovna Ratnikova, Amankeldi Kurbanovich Sadanov, Saltanat Emilievna Orasymbet, Yerik Zharylkasynovich Shorabaev, Raushan Zhumabekovna Kaptagai. Selection of an active association of Probiotic bacteria and the Optimal composition of the Nutrient medium for Cultivation to increase the Therapeutic and Prophylactic effectiveness of a Medicinal probiotic preparation against Intestinal infections. Research Journal of Pharmacy and Technology 2023; 16(5):Research Journal of Pharmacy and Technology 2023; 16(5):2427-5. doi: 10.52711/0974-360X.2023.00400
Cite(Electronic):
Nina Nikolaevna Gavrilova, Irina Alexandrovna Ratnikova, Amankeldi Kurbanovich Sadanov, Saltanat Emilievna Orasymbet, Yerik Zharylkasynovich Shorabaev, Raushan Zhumabekovna Kaptagai. Selection of an active association of Probiotic bacteria and the Optimal composition of the Nutrient medium for Cultivation to increase the Therapeutic and Prophylactic effectiveness of a Medicinal probiotic preparation against Intestinal infections. Research Journal of Pharmacy and Technology 2023; 16(5):Research Journal of Pharmacy and Technology 2023; 16(5):2427-5. doi: 10.52711/0974-360X.2023.00400 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-59
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