Author(s):
Bhakti Shah, Manisha Kotadiya, Zankhna Sheth, Ravi J. Bhatt
Email(s):
manishakotadiya3@gmail.com
DOI:
10.52711/0974-360X.2023.00391 
Address:
Bhakti Shah1, Manisha Kotadiya2*, Zankhna Sheth3, Ravi J. Bhatt4
1Department of Pharmaceutics, Shree Swaminarayan Sanskar Pharmacy College, GTU, Gandhinagar, Gujarat, India.
2Department of Pharmaceutical Chemistry, Shree Swaminarayan Sanskar Pharmacy College, GTU, Gujarat, Gandhinagar, India.
3Department of Pharmaceutics, Associate Professor, Sardar Patel College of Pharmacy, Bakrol, Anand , GTU, Gujarat, India.
4Department of Quality Assurance, B.Pharmacy College, Rampura, GTU, Gujarat, Gandhinagar, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
The oral route of drug administration is more common and convenient where tablets and capsules emerged as popular dosage form but many patients have dysphasia or difficulty in swallowing which is currently affecting 35% general population. Aprepitant is anti-emetic drug and used in the treatment of chemotherapy in cancer. Fast onset of action is required in this indication there for it was thought to prepare Oral Dispersible Tablet of Aprepitant which would help to avoid first pass metabolism and improve bioavailability also Aprepitant is insoluble in water so, to increase the solubility solid dispersion method (kneading method) was used. Here, Aprepitant ODT is prepared by direct compression method using Polyplasdone XL10 as superdisitegrant and optimized by 32 Full factorial design. Here, Polyplasdone XL10 (x1) and Mannitol(x2) is use as independent variable. while dependent variable are disintegration time and wetting time. Optimized formulation F8 batch showed drug content (98.41±0.91); disintegration time is (18.02±1.20) Wetting time (22.53±0.43). The formulation is stable at 40ºc/75% RH for 30days.
Cite this article:
Bhakti Shah, Manisha Kotadiya, Zankhna Sheth, Ravi J. Bhatt. Formulation and Characterization of Oral Dispersible Tablet of Aprepitant. Research Journal of Pharmacy and Technology 2023; 16(5):2375-0. doi: 10.52711/0974-360X.2023.00391
Cite(Electronic):
Bhakti Shah, Manisha Kotadiya, Zankhna Sheth, Ravi J. Bhatt. Formulation and Characterization of Oral Dispersible Tablet of Aprepitant. Research Journal of Pharmacy and Technology 2023; 16(5):2375-0. doi: 10.52711/0974-360X.2023.00391 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-50
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