Amber Vyas, Nagendra Singh Chauhan, Tripti Jain, A.K. Singhai, Vishal Jain
Amber Vyas1, Nagendra Singh Chauhan2, Tripti Jain4, A.K. Singhai3, Vishal Jain1*
1University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) India.
2Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur (CG), India.
3Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar (MP), India.
4Chhattisgarh FDA, Mahasamund (CG), India.
Volume - 16,
Issue - 5,
Year - 2023
Picroside-I, the irridoid glycoside component obtained from Picrorhiza kurroa Royal Ex. Benth. extract was stoichiometrically complexed with phospholipids to form Phytosome. These complexes were characterized by IR and 1H-NMR spectroscopy. The efficacy of phytosome formulation was determined by in vitro GIT absorption study which indicates greater absorption from gastrointestinal tract, resulted in higher plasma levels. The hepatic protection offered by phytosomes was studied against CCl4 induced hepatotoxicity and compared with picroside-I, by measuring bio-chemical parameters in terms of SGOT and SGPT enzyme levels. Phytosomes exhibited appreciable greater hepatoprotection than that of picroside-I alone. Therefore, phytosome can advantageously be used in acute and chronic liver disease of varying origin.
Cite this article:
Amber Vyas, Nagendra Singh Chauhan, Tripti Jain, A.K. Singhai, Vishal Jain. Picroside-1-Phytovesicle: A novel approach for Antihepatotoxic activity. Research Journal of Pharmacy and Technology 2023; 16(5):2353-8. doi: 10.52711/0974-360X.2023.00387
Amber Vyas, Nagendra Singh Chauhan, Tripti Jain, A.K. Singhai, Vishal Jain. Picroside-1-Phytovesicle: A novel approach for Antihepatotoxic activity. Research Journal of Pharmacy and Technology 2023; 16(5):2353-8. doi: 10.52711/0974-360X.2023.00387 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-46
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