Author(s):
Listijani Suhargo, Dwi Winarni, Fatimah, Viol Dhea Kharisma, Arif Nur Muhammad Ansori
Email(s):
lis.suhargo@gmail.com
DOI:
10.52711/0974-360X.2023.00376 
Address:
Listijani Suhargo1*, Dwi Winarni1, Fatimah1, Viol Dhea Kharisma2, Arif Nur Muhammad Ansori3
1Department of Biology, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia.
2Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Surabaya, Indonesia.
3Professor Nidom Foundation, Surabaya, Indonesia.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
Diabetes is caused by many factors such as hyperglycemia conditions, it triggers type 1 and 2 diabetes. Hyperglycemia was triggered by the inhibition of glucose absorption of cells and triggers an increase in ROS, insulin signaling can be disrupted due to high ROS levels, the cycle will repeat and then trigger fat accumulation, increase in proinflammatory cytokines, and exacerbate the disease. Previous studies have explained the benefits of Daun Wungu (Graptophyllum pictum L. Griff) to inhibit the activity of proinflammatory cytokines, but the molecular mechanism has not been identified. Prediction of the molecular mechanism of compound activity from Daun Wungu (Graptophyllum pictum L. Griff) with proinflammatory receptors was carried out using an bioinformatics approach, the methods used were preparation, drug-likeness prediction, docking, molecular interaction, and dynamic simulation. The results showed that quinoline compounds from Daun Wungu (Graptophyllum pictum L. Griff) had more negative binding energy with more stable chemical bonds and were predicted to inhibit the activity of proinflammatory cytokines consisting of TNF-, IL-6, and IL-8 proteins.
Cite this article:
Listijani Suhargo, Dwi Winarni, Fatimah, Viol Dhea Kharisma, Arif Nur Muhammad Ansori. Antidiabetic Activity of Daun Wungu (Graptophyllum pictum L. Griff) Extract via Inhibition Mechanism of TNF-α, IL-6, and IL-8: Molecular Docking and Dynamic Study. Research Journal of Pharmacy and Technology 2023; 16(5):2291-6. doi: 10.52711/0974-360X.2023.00376
Cite(Electronic):
Listijani Suhargo, Dwi Winarni, Fatimah, Viol Dhea Kharisma, Arif Nur Muhammad Ansori. Antidiabetic Activity of Daun Wungu (Graptophyllum pictum L. Griff) Extract via Inhibition Mechanism of TNF-α, IL-6, and IL-8: Molecular Docking and Dynamic Study. Research Journal of Pharmacy and Technology 2023; 16(5):2291-6. doi: 10.52711/0974-360X.2023.00376 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-35
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