Author(s): Ankit Loya, Latha K, Naseeb Basha Shaik, Aisha Rahman, Javeria Tamkeen

Email(s): lathakukatil@gmail.com

DOI: 10.52711/0974-360X.2023.00372   

Address: Ankit Loya, Latha K*, Naseeb Basha Shaik, Aisha Rahman, Javeria Tamkeen
Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India - 500028.
*Corresponding Author

Published In:   Volume - 16,      Issue - 5,     Year - 2023


ABSTRACT:
The purpose of this work was to study iontophoretic transport of atenolol from transdermal gel formulations through rat skin. Atenolol transdermal gels were prepared by dispersion method using natural and synthetic polymers and were evaluated for ex-vivo penetration of drug through rat skin using Franz diffusion cell. The optimized formulations F10 and F14 permeability of atenolol at 12 hours was found to be 12.52% and 13.4% respectively whereas the using iontophoresis technique drug release observed were 98.52% at 8 hours and 96.44% at 7 hours for F10 and F14 respectively. Therefore, it can be concluded that iontophoresis showed higher release when compared the gels with or without permeation enhancer (solvents). The skin irritation studies proved that there was no observed edema or erythema. In conclusion, iontophoresis is used to increase the permeation of drugs the skin.


Cite this article:
Ankit Loya, Latha K, Naseeb Basha Shaik, Aisha Rahman, Javeria Tamkeen. Formulation and Evaluation of Transdermal Gel loaded with Atenolol. Research Journal of Pharmacy and Technology 2023; 16(5):2265-2. doi: 10.52711/0974-360X.2023.00372

Cite(Electronic):
Ankit Loya, Latha K, Naseeb Basha Shaik, Aisha Rahman, Javeria Tamkeen. Formulation and Evaluation of Transdermal Gel loaded with Atenolol. Research Journal of Pharmacy and Technology 2023; 16(5):2265-2. doi: 10.52711/0974-360X.2023.00372   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-31


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