Author(s):
Wildan Khairi Muhtadi, Bambang Hernawan Nugroho, Oktavia Indrati, Ronny Martien, Nofriyanti
Email(s):
muhtadiwildan@gmail.com
DOI:
10.52711/0974-360X.2023.00371 
Address:
Wildan Khairi Muhtadi1*, Bambang Hernawan Nugroho2, Oktavia Indrati2, Ronny Martien3, Nofriyanti1
1Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Pekanbaru, Indonesia.
2Department of Pharmacy, Faculty of Mathematic and Natural Science, Universitas Islam Indonesia, Yogyakarta, Indonesia.
3Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
This study aimed to optimize the diclofenac sodium (DS)-loaded nanoemulsion (DSNE)s components, to characterize the optimum formula of DSNEs, including determining its skin penetration ability. DSNEs were optimized by the aqueous titration method to decide the optimum ratio of each component. The yielded diagram of pseudo-ternary phase was used on the considerationof the optimum formulas. The characterization of three optimum DSNEs was done by measuring the globule size, polydispersity index, zeta potential, pH, viscosity, kinetic stability, and ex-vivo permeation. One Way ANOVA (95% confidence interval) was used to analyze the cumulative DS penetrated. The optimum formulations were found with the oil:smix (surfactant:cosurfactant) ratio of 1:7(1:1), 1:7(2:1), and 1:7(3:1), which coded as DSNE1, DSNE2, and DSNE3, respectively. The three optimum formulations possessed the average droplet size of below 200nm, polydispersity index of lower than 0.7, and zeta potential of above -30 mV, respectively. There were no phase separations in the centrifugation test. DSNE3 possessed the highest DS penetrated and flux compared to other formulations. The optimization of DSNEs yielded three optimum formulations with good characteristics in accordance with the acceptance criteria of nanoemulsions. Furthermore, the smaller particle size and higher concentration of T80 enhanced the ability of DS penetration.
Cite this article:
Wildan Khairi Muhtadi, Bambang Hernawan Nugroho, Oktavia Indrati, Ronny Martien, Nofriyanti. Optimization, Characterization and Ex-vivo permeation of Nanoemulsion containing Diclofenac sodium as the development of Novel Nano-drug Delivery System. Research Journal of Pharmacy and Technology 2023; 16(5):Research Journal of Pharmacy and Technology 2023; 16(5):2257-4. doi: 10.52711/0974-360X.2023.00371
Cite(Electronic):
Wildan Khairi Muhtadi, Bambang Hernawan Nugroho, Oktavia Indrati, Ronny Martien, Nofriyanti. Optimization, Characterization and Ex-vivo permeation of Nanoemulsion containing Diclofenac sodium as the development of Novel Nano-drug Delivery System. Research Journal of Pharmacy and Technology 2023; 16(5):Research Journal of Pharmacy and Technology 2023; 16(5):2257-4. doi: 10.52711/0974-360X.2023.00371 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-30
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