ABSTRACT:
The incidence of hematological malignancies has elevated in recent decades. Chronic Myeloid Leukemia (CML) is a hematopoietic stem cell malignant clonal disorder resulting in elevation of erythroid cells and platelets in peripheral blood and clear myeloid hyperplasia in the bone marrow. Priapism is one of a rare clinical manifestation and serious complication in Chronic Myeloid Leukemia (CML). It is cause due to hematological disorder is most likely due to venous obstruction as well as hyperviscosity due to an increased number of circulating leukocytes mature and immature forms. We report a 30-year-old male came to the emergency room, presented with priapism caused by Chronic Myeloid Leukemia (CML) with hyperleukocytosis. The rarity of this case reiterates the importance of thorough morphological, cytogenetic examination along with radiology in diagnosing, treatment and follow up of patients. Starting leukemia therapy to reduce the leukocyte count immediately, can solve the problem in hyperleukocytosis that caused priapism in Chronic Myeloid Leukemia (CML).
Cite this article:
Yustisia Amalia, Paulus B. Notopuro. Priapism on Chronic Myeloid Leukemia with BCR-ABL1 Fusion gene Identified by Molecular Test: A Case Report. Research Journal of Pharmacy and Technology 2023; 16(5):2229-2. doi: 10.52711/0974-360X.2023.00366
Cite(Electronic):
Yustisia Amalia, Paulus B. Notopuro. Priapism on Chronic Myeloid Leukemia with BCR-ABL1 Fusion gene Identified by Molecular Test: A Case Report. Research Journal of Pharmacy and Technology 2023; 16(5):2229-2. doi: 10.52711/0974-360X.2023.00366 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-25
REFERENCE:
1. Nikhitha P.M, Sunil. M, Deepu. Prasad. A Study to Assess the Knowledge and Illness Perception of Parents of Children with Leukemia, Attending Oncology units, at AIMS, Kochi. Int. J. Nur. Edu. and Research 3(4): Oct.-Dec., 2015; Page 344-350. doi: 10.5958/2454-2660.2015.00021.6
2. Shinta Oktya Wardhani, Hani Susianti, Puji Rahayu, Yuyun Yueniwati. The Effect of FOXO3a rs4946936 Gene Polymorphism on Imatinib Mesylate Therapy Response in Javanese Race CML patients at Dr. Saiful Anwar General Hospital Malang. Research Journal of Pharmacy and Technology. 2022; 15(5):2250-4. doi: 10.52711/0974-360X.2022.00374
3. Sukardja DG. Onkologi klinik. Edisi 2. Surabaya : Airlangga University Press. 2000.
4. M. Rifqi Wiyono, Siprianus Ugroseno Yudho Bintoro, Yetti Hernaningsih. Characteristic of chronic myelogenous leukemia patients at the Polyclinic of Oncology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2017. Majalah Biomorfologi volume 30 number 1, January 2020. doi: 10.20473/mbiom.v30i1.2020.27-33.
5. Kiranmai Gudimetla, Orsu Prabhakar, Abhisek Pal. Review on Pathophysiological and Pharmacotherapeutic approach on Chronic Myeloid Leukemia. Research J. Pharm. and Tech 2020; 13(6): 2971-2976. doi: 10.5958/0974-360X.2020.00526.0
6. Ankit Darji, Praful Bharadia. Studies on the Quantification of Mutation Resistance to Specific Drug Therapy in Chronic Myeloid Leukemia patients. Research Journal of Pharmacy and Technology. 2021; 14(8):4092-0. doi: 10.52711/0974-360X.2021.00709
7. Ihda Kartika Syamsuddin, Budiono Paulus. Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Suabaya, Indonesia. Journal of Medical Case Reports 15:367-71. doi: 10,2147/IMCRJ.S371745
8. Muhammed A. H. Aldabagh, Sahar S. Karieb, Ali N. Yassen, Saddam H. Jaber, Mohammed S. Abbas, Ali M. Jawad. Reading of Immune picture in Chronic Myeloid Leukemia in Iraqi Patients. Research J. Pharm. and Tech. 2019; 12(4):1910-1914. doi: 10.5958/0974-360X.2019.00319.6
9. Muhammed A. H. Aldabagh, Sahar S. Karieb, Ali N. Yassen, Saddam H. Jaber, Mohammed S. Abbas, Ali M. Jawad. Reading of Immune picture in Chronic Myeloid Leukemia in Iraqi Patients. Research J. Pharm. and Tech. 2019; 12(4):1910-1914. doi: 10.5958/0974-360X.2019.00319.6
10. Burnett AL. Therapy insight. Priapism associated with hematologic dyscrasias. Nat Clin Pract Urol 2005;2:449 56. DOI: 10.1038/ncpuro0277
11. Siprianus Ugroseno Yudho Bintoro, Pradana Zaky Romadhon, Satriyo Dwi Suryantoro, et al. Case Report: Priapism as the clinical presentation of chronic myeloid leukemia in accordance with reports created during last twenty years: a case report and literature review. F1000 research 2021, 10:571. doi: 10.12688/f100research.53365.1
12. Shaeer OK, Shaeer KZ, AbdelRahman IF, et al. Priapism as a result of chronic myeloid leukemia: case report, pathology, and review of the literature. J Sex Med. 2015; 12(3): 827–34. DOI: 10.1111/jsm.12812
13. Paladino N, Roldán D, Caram MS. Priapism in pediatrics: initial presentation of chronic myeloid leukemia. Arch Argent Pediatr. 2011; 109(5): e104–8. DOI: 10.1590/s0325-00752011000500016
14. Gaye O, Thiam NM, Cassell A, et al. Unusual Presentation of Priapism Associated with Acute and Chronic Myeloid Leukemia in Two Patients: Emergency Management. Case Rep Urol. 2020; 4982432. DOI: 10.1155/2020/4982432
15. Rodgers R, Latif Z, Copland M. How I manage priapism in chronic myeloid leukaemia patients. Br J Haematol. 2012; 158(2): 155–64. DOI: 10.1111/j.1365-2141.2012.09151.x
16. Evelin Vianetha Prima Snak, Ni Nyoman Mahartini, Sianny Herawati, Ni Kadek Mulyantari, Anak Agung Wiradewi Lestari. (2022). Characteristics of patients with acute lymphoblastic leukemia in 2016-2020 at Sanglah General Hospital, Bali. Bali Medical Journal, 11(2), 646–650. DOI: 10.15562/bmj.v11i2.3607
17. Nerli RB, Magdum PV, Hiremath SC, et al. Priapism - A Rare Presentation in Chronic Myeloid Leukemia: Case Report. Urol Case Rep. 2016; 4: 8–10. DOI: 10.1016/j.eucr.2015.08.005
18. Salim, E. J., Ariawati, K., Gustawan, I. W., Windiani, I. G. A. T., Gunawijaya, E., & Hartawan, I. N. B. (2020). Diagnostic Accuracy of Bone Marrow Morphology to Determine Remission in Acute Lymphoblastic Leukemia Children: The Role of Minimal Residual Disease. Bali Medical Journal, 9(1), 366–370. DOI: 10.15562/bmj.v9i1.1678
19. R. Swetha Sri, Soundarya, K. Bhavya Sri, M. Sumakanth. Stability Indicating UV-Spectrophotometric Method Development and its Validation for the Determination of Imatinib Mesylate in Bulk and Formulation. Asian Journal of Pharmaceutical Analysis. 2022; 12(2):83-6. doi: 10.52711/2231-5675.2022.00015
20. Prabawa, I. P. Y., Mahartini, N. N., Herawati, S., & Mulyantari, N. K. (2022). Acute Erythroleukemia (AML-M6) in one-year-old boy: a case report. Bali Medical Journal, 11(3), 1420–1425. DOI: 10.15562/bmj.v11i3.3803
21. Novia, Rosdiana, N., Supriatmo. (2022). Serum ferritin level in pediatric patients with acute lymphoblastic leukemia (ALL) in the early stage of diagnosis and remission phase. Bali Medical Journal, 11(3), 1598–1602. DOI: 10.15562/bmj.v11i3.3595
22. Yulizar, D. R., Maulani, E. P., Prasetya, H., Sutapa, H., & Rahman, E. Y. (2021). Penile gangrene as a priapism sequele due to Chronic Myeloid Leukemia (CML): the first report in Indonesia. Bali Medical Journal, 10(1), 108–110. DOI: 10.15562/bmj.v10i1.2125