Author(s):
Sudipta Chakraborty, Nripendra Nath Bala, Sudipta Das
Email(s):
sudislg3@gmail.com
DOI:
10.52711/0974-360X.2023.00357 
Address:
Sudipta Chakraborty1*, Nripendra Nath Bala1, Sudipta Das2
1BCDA College of Pharmacy and Technology, 78, Jessore Road (S), Hridaypur, Barasat, Kolkata: 700127, West Bengal, India.
2Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
The present study investigated centrally and peripherally mediated analgesic activity of methanol extract of leaves of Bauhinia acuminata and isolation of active compounds by column chromatography with gradient elution using combination of different solvents. FTIR, 1H and 13C NMR spectral data of the isolated compound established it to be a flavonol, quercetin. The analgesic activity of the extract was found to be dose dependent and effective in all the models tested being Acetic acid induced visceral pain model as the best (p<0.01 in all the doses tested). In hot plate method the test extract showed significant analgesia (p<0.01) compared to the control only for 200 and 400mg/kg BWfor all the reaction times tested, but the 100mg mg/kg BW was able to show the same only after 45 min. Formalin induced tonic pain model also exhibited similar results that indicated better analgesia was achieved at late phase (10-30 min). The analgesic activity of this extract may be correlated with that of the available phytochemical data obtained for this plant which indicates the presence of flavonoids and alkaloids as the chief constituents in leaves. In all the test models the results were promising and near to that of the standards used indicating it’s competence in the pain and related therapies which may be validated by further clinical studies.
Cite this article:
Sudipta Chakraborty, Nripendra Nath Bala, Sudipta Das. Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn. Research Journal of Pharmacy and Technology 2023; 16(5):2177-1. doi: 10.52711/0974-360X.2023.00357
Cite(Electronic):
Sudipta Chakraborty, Nripendra Nath Bala, Sudipta Das. Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn. Research Journal of Pharmacy and Technology 2023; 16(5):2177-1. doi: 10.52711/0974-360X.2023.00357 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-16
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