Author(s): Aladhiana Cahyaningrum, Dian Handayani, Djoko Wahono Soeatmadji, Masruroh Rahayu, Surya Hadi

Email(s): aladhiana.cahyaningrum@gmail.com , handayani_dian@ub.ac.id , djokowsoeatmadji@gmail.com , masrurohrahayu.fk@ub.ac.id , sur_hadi88@yahoo.com

DOI: 10.52711/0974-360X.2023.00356   

Address: Aladhiana Cahyaningrum1,2, Dian Handayani3, Djoko Wahono Soeatmadji4, Masruroh Rahayu5, Surya Hadi6
1Nutrition Department, Mataram Health Polytechnic, Ministry of Health of the Republic of Indonesia, Jl. Praburangkasari Dasan Cermen, 83232 Sandubaya, Mataram, Lombok.
2Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Brawijaya Jl. Veteran, Malang 65145, East Java, Indonesia.
3Faculty of Health Sciences, Universitas Brawijaya, Jl. Puncak Dieng, Kunci, Kalisongo, Dau District, Malang 65151 East Java, Indonesia.
4Internist Department, Faculty of Medicine, Universitas Brawijaya, Jl. Veteran, Malang 65145, East Java, Indonesia.
5Faculty of Medicine, Universitas Brawijaya, Jl. Veteran, Malang 65145, East Java, Indonesia.
6Faculty of Math and Science, Universitas Mataram. Jl. Majapahit No 62, Mataram 83126, West NusaTenggara.
*Corresponding Author

Published In:   Volume - 16,      Issue - 5,     Year - 2023


ABSTRACT:
Moringa (Moringa oleifera) is a plant that easily to find and can grow in lowlands and highlands such as Lombok island relatively inexpensive , and can thrive in almost all parts of Indonesia, such as Lombok island, West Nusa Tenggara province. All parts of this plant can be used as food and traditional medication such as diabetes mellitus. This study aims at identifying the chemical compounds that contained in Moringa oleifera of Lombok island and predicting its role as a treatment of diabetes mellitus disease. Identification of chemical compounds by using the spectropotometry method and antioxidant activity with the DPPH method, the prediction of the potential of Moringa leaves (Moringa oleifera) for Treatment of Diabetes Mellitus with the in Silico approach. Analysis of Pa (probability to be active) by using the approach of Pass Server, predicted that moringa oleifera can be used for the treatment of diabetes. The qualitative analysis results of phytochemical, moringa leaf powder from Lombok Island positive contain of alkaloids, flavonoids, tannins and phenols, and quantitative analysis, moringa leaf powder contain of polyphenols (864.09mgGAE/100g), flavonoids (649.97 mgQE/100g), tannin (306,10mgTAE/100g), quercetin (30.33mgQE/100g), and has an antioxidant capacity (1247.02 mgGAEAC/L) and antioxidant activity with the value IC50 (1312.99 ppm). Moringa leaf powder from Lombok Island contains of alkaloid compounds, polyphenols, flavonoids, tannins, phenols and quercetin and has very weak antioxidant capacity and activity. Moringa leaves (Moringa oleifera) can target RBP4, SLC16A1, SRC and IRS1 protein associated with insulin pathway so that it is predicted to be used for treatment of diabetes mellitus disease.


Cite this article:
Aladhiana Cahyaningrum, Dian Handayani, Djoko Wahono Soeatmadji, Masruroh Rahayu, Surya Hadi. Phytochemical screening and Antioxidant activity of Lombok island local Moringa leaf powder (Moringa oleifera) predicted for Diabetes Therapy. Research Journal of Pharmacy and Technology 2023; 16(5):2169-6. doi: 10.52711/0974-360X.2023.00356

Cite(Electronic):
Aladhiana Cahyaningrum, Dian Handayani, Djoko Wahono Soeatmadji, Masruroh Rahayu, Surya Hadi. Phytochemical screening and Antioxidant activity of Lombok island local Moringa leaf powder (Moringa oleifera) predicted for Diabetes Therapy. Research Journal of Pharmacy and Technology 2023; 16(5):2169-6. doi: 10.52711/0974-360X.2023.00356   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-5-15


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