Author(s): R Meena, G Kiruthiga, P Prakash


DOI: 10.52711/0974-360X.2023.00338   

Address: R Meena1*, G Kiruthiga2, P Prakash3
1Central Council for Research in Siddha, Chennai - 600106, India.
2Central Council for Research in Siddha, Chennai - 600106, India.
3Sathyabama Institute of Science and Technology, Department of Biotechnology, Chennai - 600119, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 4,     Year - 2023

Siddha medicine is an ancient Indian medical system originated in South India. The holistic approach of the Siddha system finds cure for many ailments and also guides to a perfect living right from conception to death. The ‘S’ in the acronym AYUSH represents Siddha. The Siddha multiherbal formulation Mahathuthulathi chooranam, found in the classical text book Koshayi Anuboga Vaithiya Bramma Ragasiyam - part 2, is indicated for Aiyam (Phlegm) predominant diseases. The review seeks to establish the documented literature on the therapeutic efficacy of the Mahathuthulai chooranam in respiratory illness through a critical review. It was carried out by searching Siddha classic texts from the library of Siddha Central Research Institute, electronic search engines, databases such as Google scholar, Pub Med Central, NLM, Mendeley, Embase, Science Direct etc. The results of the review suggest that the drug can be a part of the comprehensive treatment of adverse respiratory illnesses in addition to prevention of complications in vulnerable risk patients. The drug is substantiated to be a safe and efficacious drug in treating acute respiratory illnesses through supporting evidences. A robust clinical trial is essential to evaluate the clinical outcomes to prove the drug’s efficiency.

Cite this article:
R Meena, G Kiruthiga, P Prakash. Evaluation of Siddha Compound Formulation Mahathoothulai chooranam in Combating Respiratory Illness: A Narrative Review. Research Journal of Pharmacy and Technology 2023; 16(4):2057-0. doi: 10.52711/0974-360X.2023.00338

R Meena, G Kiruthiga, P Prakash. Evaluation of Siddha Compound Formulation Mahathoothulai chooranam in Combating Respiratory Illness: A Narrative Review. Research Journal of Pharmacy and Technology 2023; 16(4):2057-0. doi: 10.52711/0974-360X.2023.00338   Available on:

1.    Anaivarai R Anandhan.  Principles of diagnosis in Siddha-part 1(Tamil). Department of Indian Medicine and Homoeopathy, Chennai.2009
2.    Ramachandiran SP, Koshayi anuboga vaithiya Bramma ragasiyam part 2 (Tamil).1st Ed.Thamarai noolagam, Chennai.1999.
3.    Anaivarai R Anandhan. A compendium of Siddha Doctrine.Department of Indian Medicine and Homoeopathy, Chennai. 2005.
4.    Kuppuswamy Mudhaliyar KN. Siddha Maruthuvam Podhu. 6th Ed. Department of Indian Medicine and Homoeopathy, Chennai. 2004.
5.    Anaivarai R Anandhan. A compendium of Siddha Doctrine. Department of Indian Medicine and Homoeopathy, Chennai.2005.
6.    Bhavishya Haniya TK. Lavanya J. Rasiga R. Nandini VS. Samuel Justin raj C. Vibinshiya G et al. Role of tastes in treatment modalities of Siddha science. Siddha Papers. 2016; 1(1).
7.    Murugesa Mudhaliyar. Siddha Materia Medica- Part 1. 7th Ed. Department of Indian medicine and Homoeopathy, Chennai.2003
8.    Somnath Dea. Akalanka Deyb. Sudhakar Babuc AMS. Siddabathuni Aneelaa. Phytochemical and GCMS analysis of bioactive compounds of Sphaeranthus amaranthoides Burm. Pharmacognosy Journal. 2013; 265 -68.
9.    Swarnalatha. Y. Isolation of Flavonoids and their Anticancer Activity from Sphaeranthus amaranthoides in A549 Cell Line. Research J. Pharm. and Tech. 2015; 8(4):462-467. doi: 10.5958/0974-360X.2015.00077.3
10.    Nirmala DN. Ramachandramurthy. Primary phytochemical screening of Solanum Trilobatum L. young leaves. International research journal of Pharma. 2014; 5(2):80-82.
11.    Dewangan H. Bais M. Jaiswal V.Verma VK. Potential wound healing activity of the ethanolic extract of Solanum xanthocarpum schrad and wendl leaves. Pakistan Journal of Pharmaceutical Sciences. 2012; 25(1):189-94.
12.    Sharma M. Shashank B. Suresh D. Nupur J. Jyoti N. Phytochemical screening of secondary metabolites of Solanum xanthocarpum fruits pericarp. International Journal of Current Pharmaceutical Research. 2013; 5 (2):148-50.
13.    Ghosh AK., Sen D.Bhattacharya S. A new alkaloid isolated from Abies webbiana leaf. Pharmacognosy research. 2010; 2(3):186–189.
14.    Srividya. Ammayappan rajam. Dhanabal SP. Misra V. Suja G. Antioxidant and Antimicrobial Activity of Alpinia officinarum. Indian journal of pharmaceutical sciences. 2010; 72:145-8.  
15.    Manisha NT. Archana K. Urmila DV. Charmi PS. Santani DD. Pharmacognostic, phytochemical analysis and antimicrobial activity of two Piper Species. Pharmacie Globale.  2011; 7 (05):1-4
16.    Santana FP. Pinheiro NM. Mernak MI. Righetti RF. Martins MA. Lago JH. Lopes FD. Tibério IF. Prado CM. Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases. Mediators of Inflammation. 2016; 2348968.
17.    Thanigavelan V. Lakshmanakumar V. Kaliyamurthi V. Pitchiah Kumar M. Victor Rajamanickam G. Pharmacological Study of a Siddha Holistic Herb Sivakaranthai - Sphaeranthus Amaranthoides Burm for Analgesic and Anti-Inflammatory activities. Journal of Applied Pharmaceutical Science. 2012; 02 (01): 95-101.
18.    Govindan S. Viswanathan S. Vijayasekaran V. Alagappan R. A pilot study on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma. Journal of Ethnopharmacology. 1999; 66(2):205-10.
19.    Gautam P.Vadnere RS Gaud. Abhay KS. Evaluation of anti-asthmatic property of Solanum xanthocarpum flower extracts. Pharmacology online. 2008; 1: 513-22.
20.    Siva SN. Ashoke KG. Bikash D. Satya Prakash V. Tarun J. Synergistic effect of methanol extract of Abies webbiana leaves on sleeping time induced by standard sedatives in mice and anti-inflammatory activity of extracts in rats. Journal of Ethnopharmacology.  2004; 93: 397–402
21.    Honmore VS.Kandhare AD. Kadam PP. Khedkar VM.Sarkar D. Bodhankar SL. Zanwar AA. Rojatkar SR. Natu AD. Isolates of Alpinia Officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies. International Immunopharmacology. 2016; 33:8-17.
22.    Liu Y. Yadev VR. Aggarwal BB. Nair MG. Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. Natural Product Communications. 2010; 5(8):1253-1257.
23.    Favarin DC. De Oliveira JR. De Oliveira CJ. Rogerio AP. Potential effects of medicinal plants and secondary metabolites on acute lung injury. Biomed research international. 2013; 576479.
24.    Parasuraman S. Yu Ren L. Lau Chik Chuon B. Wong Kah Yee S. Acute and Sub-chronic Toxicological Evaluation of Ethanol Extract of Solanum trilobatum Linn. Research Journal of Pharmacognosy. 2018; 5(1):13-21
25.    Shirish S. Pingale. Evaluation of Acute Toxicity for Solanum Xanthocarpum Fruits. BioMed Rx. 2013; 1(3):330-32.
26.    Parkash O. Kumar D. Kumar S. Screening of Methanol Extract and Ethyl Acetate Fraction of Abies webbiana Lindl. for Neuropharmacological Activities. Indian Journal of Pharmaceutical Sciences. 2015; 77(5):536-41.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available