Author(s):
Himanshu Chaurasia, Himansu Chopra, Manoj Kumar Sagar, Ranjit Singh
Email(s):
himanshuj02@gmail.com
DOI:
10.52711/0974-360X.2023.00321 
Address:
Himanshu Chaurasia1*, Himansu Chopra2, Manoj Kumar Sagar3 and Ranjit Singh1
1Facuty of Pharmacy, Adarsh.Vijendra. Institute of.Pharmaceutical.Sciences, Shobhit.University,.Gangoh, Saharanpur (UP).
2Research Scholar, Adarsh.Vijendra. Institute of.Pharmaceutical.Sciences,
Shobhit.University,.Gangoh, Saharanpur (UP).
3Government.College of Pharmacy, B R D Medical College Campus, Gorakhpur (UP).
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2023
ABSTRACT:
The present research work was done with the objective of topical formulation development of poorly water-soluble drug Mefenamic acid. The drug was firstly incorporated in nanosponge of ethyl cellulose. Then Mefenamic acid nanosponge-loaded topical gel formulations were developed by using Carbopol 934 as a gel-forming polymer. The Mefenamic acid-loaded nanosponges were tested for various quality parameters such as particle size distribution, polydispersity.index(PI),. Surface morphology and drug entrapment efficiency etc. Gel formulations were tested for viscosity, pH, in vitro diffusion and other parameters. The average size of developed nanosponge preparations was found between 250nm to 894nm. Scanning electron microscopy photographs of developed formulations clearly reveal the spongy and porous nature of particles along with spherical shape. The PI was. found in. the range. of 0.206 to 0.934. It was found that formulation N3 with a drug-to-polymer ratio of 1:4 has the highest drug loading. Further nanosponge were characterized for different parameters and results revealed acceptable characteristics of N3 formulation. These prepared nanosponges were loaded in topical Carbopol gel (Formulation G3) and evaluated for in vitro diffusion release. Obtained in vitro data was applied to numerous kinetic models which reveal typical zero order in vitro drug diffusion with prolonged release of Mefenamic acid and therefore it can be effectively used as analgesic and anti-inflammatory formulation.
Cite this article:
Himanshu Chaurasia, Himansu Chopra, Manoj Kumar Sagar, Ranjit Singh. Development and in vitro assessment of Analgesic and Anti-inflammatory Mefenamic acid Nanosponge Loaded Topical Formulation. Research Journal of Pharmacy and Technology 2023; 16(4):1960-4. doi: 10.52711/0974-360X.2023.00321
Cite(Electronic):
Himanshu Chaurasia, Himansu Chopra, Manoj Kumar Sagar, Ranjit Singh. Development and in vitro assessment of Analgesic and Anti-inflammatory Mefenamic acid Nanosponge Loaded Topical Formulation. Research Journal of Pharmacy and Technology 2023; 16(4):1960-4. doi: 10.52711/0974-360X.2023.00321 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-4-70
REFERENCES:
1. Pavithra P.P. Mehta C.H. Nayak U.Y. Nanosponges-Revolutionary Approach: A Review. Research Journal of Pharmacy and Technology. 2020; 13(7): 3536-3544.doi: 10.5958/0974-360X.2020.00626.5
2. Harsha G. Shaik N.B. Lakshmi P.K. Latha K. Formulation and Evaluation of Sertaconazole nitrate loaded Nanosponges for topical application. Research Journal of Pharmacy and Technology. 2021; 14(2):895-902.doi: 10.5958/0974-360X.2021.00159.1
3. John D. Charyulu R.N. Ravi G.S. Jose J. Nanosponge Based Hydrogels of Etodolac for Topical Delivery. Research Journal of Pharmacy and Technology. 2020; 13(8):3887-3892.doi: 10.5958/0974-360X.2020.00688.5
4. Praveen K. Balamurugan K. Targeted Drug Delivery through Nanosponges and its Approach. Research Journal of Pharmacy and Technology. 2020; 13(7): 3524-3529. doi: 10.5958/0974-360X.2020.00624.1
5. Gedam S.S. Basarkar G.D. Formulation, Design and In-Vitro Characterization of Clopidogrel Bisulphate Nanosponge Tablets for Oral Administration. Research Journal of Pharmacy and Technology. 2021; 14(4):2069-5. doi: 10.52711/0974-360X.2021.00367.
6. Ranjitha R. Elango K. Damayanthi D.R. Niyaz S.H. Formulation and Evaluation of Lovastatin Loaded Nanosponges for the treatment of Hyperlipidemia. Research Journal of Pharmacy and Technology. 2021; 14(11):5653-0. doi: 10.52711/0974-360X.2021.00983
7. Ahmed M.M. Fatima F. Anwer M.K. Ibnouf E.O. Kalam M.A. Alshamsan A. Aldawsari M.F. et al. Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection. Saudi Pharmaceutical Journal. 2021; 29(5): 467-477. doi.org/10.1016/j.jsps.2021.04.010
8. Iriventi P. Gupta N.V. Osmani R. Balamuralidhara V. Design & development of nanosponge loaded topical gel of curcumin and caffeine mixture for augmented treatment of psoriasis. Daru. 2020; 28(2):489-506.doi: 10.1007/s40199-020-00352-x.
9. Khullar R. Kumar D. Seth N. Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal. 2012; 20(1): 63-67.doi.org/10.1016/j.jsps.2011.08.001
10. Srinivas P. Sreeja K. Formulation and Evaluation of Voriconazole Loaded Nanosponges for Oral and Topical Delivery. International Journal of Drug Delivery & Research. 2013;5(1):55-69.
11. Vyas A. Kumar S.A. Gidwani B. Carrier-Based Drug Delivery System for Treatment of Acne. The Scientific World Journal. 2014; 1–14.
12. Ahmed M.M. Anwer M.K. Fatima F. Iqbal M. Ezzeldin E. Alalaiwe A. Aldawsari M.F. Development of ethylcellulose based nanosponges of apremilast: In vitro and in vivo pharmacokinetic evaluation. Latin American Journal of Pharmacy. 2020; 39: 1292–1299.
13. Pawar S. Shende P. Trotta F. Diversity of beta-cyclodextrin-based nanosponges for transformation of actives. International Journal of Pharmaceutics. 2019; 565: 333–350.
14. Rao M.R.P. Chaudhari J. Trotta F. Caldera F. Investigation of Cyclodextrin based Nanosponges for Solubility and Bioavailability Enhancement of Rilpivirine. AAPS PharmSciTech. 2018; 19: 2358–2369.
15. Shoaib Q. Abbas N. Irfan M. Hussain A. Arshad M.S. Hussain S.Z. Latif S. et al. Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen. Tropical Journal of Pharmaceutical Research. 2018; 17.doi: 10.4314/tjpr.v17i8.2.
16. Sri K.V. Santhoshini G. Sankar R, Niharika K. Formulation and Evaluation of Rutin Loaded Nanosponges. Asian Journal of Research in Pharmaceutical Sciences. 2018; 8(1):21-24.
17. Munshi P.P. Mohale D.S. Akkalwar R. Chandewar A.V. Formulation and Evaluation of Diclofenac gel. Research Journal of Pharmacy and Technology. 2011; 4(9):1394-1399.
18. Nitalikar M.M. Sakarkar D.M. Formulation and evaluation of topical gel of Meloxicam with Beta-Cyclodextrin complex. Research Journal of Pharmacy and Technology. 2013; 6(9): 790-793.
19. Sadhasivam J. Sugumaran A. Narayanaswamy D. Nano Sponges: A Potential Drug Delivery Approach. Research Journal of Pharmacy and Techno;ogy. 2020; 13(7): 3442-3448.
20. Sankar V. Kumar P. Roselin R. Development of Mupirocin- Tinidazole solid- Lipid Nanoparticles Loaded Topical gel for the Management of Bacterial Wound Infections. Research Journal of Pharmacy and Technology. 2021; 14(5):2785-0.
21. Manmohan S.J. Gupta A. Sah A.K. Formulation and Evaluation of Sustained Release Topical Gel of Flurbiprofen Using Natural Polymers. Research Journal of Topical and Cosmetic Sciences. 2014; 5(1): 7-11.
22. Dange Y.D. Honmane S.M. Patil P.A. Gaikwad U.T. Jadge D.R. Nanotechnology, Nanodevice Drug Delivery System: A Review. Asian Journal of Pharmacy and Technology. 2017; 7(2): 63-71.
23. Rathore R.P.S. Nema R.K. Formulation and Estimation of Rheological Parameters of Topical Gels of Ketoprofen. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(3):226-228.
24. Balwe M.B. Nanosponge A Novel Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology.2020; 12(4):261-266.
25. Yadav R.P. Sheeba F.R. Nanosponges - Overview. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(2):127-3.
26. Karudumpala S. Sangeeetha G. Praksh K.G. Harikrishna G. Balaji G. Anudeep K. Formulation and Evaluation of Carisoprodol Topical Gel. Research Journal of Pharmacy and Technology. 2014; 7(1): 34-38.
27. Maanvizhi S. Iyyappan V. Bhavishi P.G. In-vitro release study of Diclofenac sodium from topical gel formulations using diffusion cell. Research Journal of Pharmacy and Technology. 2020; 13(6): 2901-2905.