This study aims to prepare prolonged-release Celecoxib transdermal patches due to the multiple advantages of patches. Several formulations were prepared using Ethylcellulose (EC) as a hydrophobic polymer with different plasticizers such as Span 60, Silicon oil, Oleic acid, or Polyethylene Glycol 400 (PEG400). Different properties of the prepared patches (in terms of weight uniformity, content uniformity, folding endurance, and in vitro drug release) were studied. The effect of changing polymer concentration and type of plasticizer and its concentration on patch properties were investigated. The results showed that ˜90% of Celecoxib was released after 24 hours by using EC at a concentration of 0.5% with PEG 400(25% w/w with respect to dry weight of polymer). The prepared films were transparent, visually homogenous, and flexible as the folding endurance value was 500±1.52 folds and Celecoxib release followed Higuchi model, meaning that the diffusion of Celecoxib through the EC chains is the main mechanism of release.
Cite this article:
Lama Alhaushey, Ranin Darwish Ahmad. Formulation and Evaluation of Celecoxib Transdermal Patches. Research Journal of Pharmacy and Technology 2023; 16(4):1574-0. doi: 10.52711/0974-360X.2023.00257
Lama Alhaushey, Ranin Darwish Ahmad. Formulation and Evaluation of Celecoxib Transdermal Patches. Research Journal of Pharmacy and Technology 2023; 16(4):1574-0. doi: 10.52711/0974-360X.2023.00257 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-4-5
1. Aulton, Michael E. Aulton’s Pharmaceutics : the Design and Manufacture of Medicines / Edited by Michael E. Aulton. 3rd ed. Edinburgh: Churchill Livingstone, 2007. Print.
2. MONIKA, Bhairam, et al. Transdermal drug delivery system with formulation and evaluation aspects: overview. Research Journal of Pharmacy and Technology, 2012, 5.9: 1168..
3. Chorghe, Bhakti R., et al. Transdermal drug delivery system: A review. Research Journal of Pharmaceutical Dosage Forms and Technology, 2013, 5.2: 65-9..
4. Ranjan, Alok, et al. A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS). Research Journal of Pharmaceutical Dosage Forms and Technology, 2018, 10.2: 90-94..
5. Ranade, Vasant V., Hollinger, Mannfred A. and Cannon, John B. Drug delivery systems. CRC press, 2003..
6. Patel, D. and Kavitha, K. Formulation and evaluation aspects of transdermal drug delivery system. International journal of pharmaceutical sciences review and research, 2011, 6: 1-12..
7. Savoji, Houman, Mehdizadeh, Amir and RAMAZANI Saadat Abadi, Ahmad. Transdermal nitroglycerin delivery using acrylic matrices: design, formulation, and in vitro characterization. International Scholarly Research Notices, 2014, 2014..
8. Singh, Jatav Vijay, et al. Design, formulation and in vitro drug release from transdermal patches containing Nebivolol hydrochloride as model drug. Asian Journal of Pharmaceutical Research, 2012, 2.4: 136-141..
9. HUSSAIN, Ismail, et al. Design and Evaluation of Transdermal Patches Containing Risperidone. Asian Journal of Research in Pharmaceutical Science, 2016, 6.4: 208-222..
10. Vasavi, G., Haritha, P. Naga and Chandrashekar, B. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Evaluation, 2018, 8.8: 8..
11. AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar. Formulation, Optimization and Evaluation of Glibenclamide Transdermal Patches by using chitosan Polymer. Asian J. Pharm. Tech. 2019 and 9(1):01-07.
12. Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera.. Approaches and Current Trends of Transdermal Drug Delivery System- A Review. Research J. Pharma. Dosage Forms and Tech. 2013 and 177-190., 5(4):.
13. Harshal S Patil, Sourabh Jain, Karunakar Shukla, Paresh A Patil. Development and Evaluation of Transdermal patches of Piperine hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology.2022 and 14(2):133-8.
14. Jan, Wisher D. Martindale: The Complete Drug Reference. 37th ed. J Med Libr Assoc. 2012 and PMC3257481., 100(1):75–6. doi: 10.3163/1536-5050.100.1.018. PMCID:.
15. Jayaprakash S, Halith SM, Firthouse PM, Yasmin, Nagarajan M. Preparation and evaluation of celecoxib transdermal patches. Pak J Pharm Sci. 2010 Jul and 20566440., 23(3):279-83. PMID:.
16. Moghimipour, Eskandar and Baniahmad, Binazir. (2015). Formulation and Evaluation of Transdermal Celecoxib Matrix Patches. European Journal of Biomedical and Pharmaceutical sciences. 2. 34-43.
17. Alam MI, Baboota S, Kohli K, Ali J, Ahuja A. Development and evaluation of transdermal patches of celecoxib. PDA J Pharm Sci Technol. 2009 and 63(5):429-437.
18. Sharma, R. and Mehra, G.R.. (2011). Preparation, characterization, in vitro and in vivo evaluation of transdermal matrix films of celecoxib. Acta Pharmaceutica Sciencia. 53. 67-76.
19. Studies on the development of celecoxib transdermal patches. M.Y. Begum, K.Abubulu, M.Sudhakar, S.Jayaprakash. India : International Journal of PharmaTech Research, 2011, Vols. Vol.3, No.3. ISSN: 0974-4304.
20. Pratik Terse, Rashmi Mallya. Formulation and Evaluation of Celecoxib loaded colon Targeted Microsponges. Asian J. Res. Pharm. Sci. 2020 and 10(2):73-78.
21. Praveen Kumar, Meenu Chaudhary, S Bhattacharya, Vijay Juyal. Validated Analytical Method Development of Celecoxib in Bulk, Tablet and Rat Plasma by UV-Spectroscopy. Research J. Pharm. and Tech.3 (3): July-Sept. 2010 and 894-896., Page.
22. Shaikh Sohel, M. Najmuddin, Hariprasanna R. C., Kishore V. C. Development and Evaluation of Orally Disintegrating Tablet of Celecoxib for Juvenile Rheumatoid Arthritis. Research J. Pharm. and Tech. 6(8): August 2013 and 865-867., Page.
23. RamtekeK., H., DigheP.A, 1., and Kharat A. R 1., P.S. Mathematical Models of Drug Dissolution : A Review.
24. Madoria N., Maheshwari Y. Formulation, Optimization and Characterization of Fast Dissolving Tablet of Celecoxib. Research J. Pharm. and Tech. 5(8): August 2012 and 1085-1088., Page.
25. O.S.S.Chandana, R.Ravichandrababu. Assay Method Development and Validation for Celecoxib Dosage Forms by High Performance Liquid Chromatography. Research J. Pharm. and Tech 2016 and 1951-1956., 9(11):.
26. Elmets CA, Ledet JJ, Athar M. Cyclooxygenases: mediators of UV-induced skin cancer and potential targets for prevention. J Invest Dermatol. 2014 and doi:10.1038/jid.2014.192, 134(10):2497-2502.
27. Treatment with 5-Fluorouracil and Celecoxib Displays Synergistic Regression of Ultraviolet Light B-Induced Skin Tumors. Traci A. Wilgus, Thomas S. Breza, Kathleen L. Tober, Tatiana M. Oberyszyn,. Issue 6,, s.l. : Journal of Investigative Dermatology, 2004, Vols. Volume 122,. ISSN 0022-202X.
28. Beny Baby, Abin Abraham, S Jayaprakash. Design and Evaluation of Transdermal Patches of Propanolol Hydrochloride. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009 and 195-200., Page.
29. The United states Pharmacopoeia 36 NF31, 2013.
30. J Thimmasetty, CVS Subrahmanyam, BA Vishwanath, PR Sathesh Babu. Solubility Parameter Estimation of Celecoxib by Current Methods. Asian J. Research Chem. 2(2): April.-June, 2009 page 188-195.
31. Council of Europe., European Pharmacopoeia Commission., and European Directorate for the Quality of Medicines and Healthcare. (2010). European pharmacopoeia. Strasbourg: Council Of Europe.
32. Patel, K.N., Patel, H.K., and Patel, V.A. (2012). Formulation AND Characterization of Drug In Adhesive Transdermal PATCHES OF DICLOFENAC ACID Research Article.
33. Liji Jacob, Manju Salim S, Jilby Saju. Formulation and Evaluation of Transdermal Patches of Selegiline. Asian Journal of Pharmacy and Technology. 2022 and 12(2):96-0.
34. Megha B. Hiroji, Nagesh C., Devdatt Jani, Chandrashekhara S.. Development and Evaluation of Transdermal Drug Delivery System using Natural Polysaccharides.. Research J. Pharma. Dosage Forms and Tech. 2012 and 278-284., 4(5):.
35. hakraborty Prithviraj, Dey Biplab K., Bahadur Sanjib, Thakkar Suresh, Das Sudip. Design, Development, Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose - Povidone Matrices. Research J. Pha.
36. Suja C., Ramasamy C., Narayanacharyulu R. Development and Evaluation of Lisinopril Transdermal Patches. Research J. Pharm. and Tech. 4(8): August 2011 and 1260-1264., Page.
37. VERMA, Navneet and DESHWAL, Shikha. Design and in vitro evaluation of transdermal patches containing Ketoprofen. World Journal of Pharmaceutical Research, 2014, 3.3: 3930-44..
38. Shirisha S, Joshi G, Sahoo SK, Rao YM. Preparation and Evaluation of Matrix Type Transdermal Patches of Domperidone Maleate: in vitro and ex vivo Characterization. Indian J of Pharmaceutical Education and Research. 2017 and 51(4):517-24.
39. Kalpak Gajbhiye, Nawaz Hakam, Gauri Rathod, Mukund Tawar. Formulation and Evaluation of Transdermal Patches of Benidipine Hydrochloride. Asian Journal of Pharmacy and Technology 2021 and 11(3):207-2.
40. Dey BK, Kar PK, Nath LK. Formulation Design, Preparation and In vitro – In vivo Evaluation of Propranolol Hydrochloride Transdermal Patches using Hydrophilic and Hydrophobic Polymer complex. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009 and 155-160, Page.
41. Arijit Das, Sibaji Ghosh, Sudip Das, Biplab Kr. Dey, Tarun Kanti Ghosh. Formulation and In Vitro Evaluation of Transdermal Patches of Metformin Hydrochloride Using Hydrophilic and Hydrophobic Polymer Complex. Research J. Pharm. and Tech. 4(4): April 2011.
42. S. S. Solanki, K. B. Patel, J. G. Patel, M. P. Patel, J. K. Patel. Development of Matrix Type Transdermal Patches of Granisetron Hydrochloride: Physicochemical and In-vitro Characterization. Research J. Pharm. and Tech. 5(7): July 2012 and 973-977., Page.
43. Idrees A, Rahman NU, Javaid Z, Kashif M, Aslam I, Abbas K, Hussain T. In vitro evaluation of transdermal patches of flurbiprofen with ethyl cellulose. Acta Pol Pharm. 2014 Mar-Apr and 25272649., 71(2):287-95. PMID:.
44. Dante MCL, Borgheti-Cardoso LN, Fantini MCA, et al. Liquid Crystalline Systems Based on Glyceryl Monooleate and Penetration Enhancers for Skin Delivery of Celecoxib: Characterization, In Vitro Drug Release, and In Vivo Studies. J Pharm Sci. 2018 and 107(3):87.
45. Cid YP, Pedrazzi V, de Sousa VP, Pierre MB. In vitro characterization of chitosan gels for buccal delivery of celecoxib: influence of a penetration enhancer. AAPS PharmSciTech. 2012 and doi:10.1208/s12249-011-9725-8, 13(1):101-111.
46. Jayaprakash, S. et al. “Design and Evaluation of Monolithic Drug-In- Adhesive Transdermal Patches of Meloxicam.” (2011).
47. Quiñones OG, Mata dos Santos HA, Kibwila DM, et al. In vitro and in vivo influence of penetration enhancers in the topical application of celecoxib. Drug Dev Ind Pharm. 2014 and doi:10.3109/03639045.2013.809731, 40(9):1180-1189.
48. Kulkarni, Raghavendra Vinayakarao et al. “Effect Of Plasticizers On The Permeability And Mechanical Properties Of Eudragit Films For Transdermal Application.” Indian Journal of Pharmaceutical Sciences 64 (2002): 28-31.
49. AMJAD, Mohd, et al. Formulation and evaluation of transdermal patches of atenolol. Advance Research in Pharmaceuticals and Biological, 2011, 1.2: 12-23..
50. Madhulatha, A. Venkata Satya and T NagaRavikiran. “Formulation and Evaluation of Ibuporfen Transdermal Patches.” (2013).
51. Onunkwo, Godswill and Onyishi, Ikechukwu. (2013). Kinetics and Mechanisms of Drug Release from Swellable and Non Swellable Matrices: A Review. Research Journal of Pharmaceutical, Biological and Chemical Sciences. Volume 4. 97-103.