ABSTRACT:
Ajuga orientalis L. is a member of the Lamiaceae family. Many biological properties of A. orientalis, such as antibacterial, anticancer, antioxidant, and anti-inflammatory activities, have been documented. The current study aims to assess the in vitro antidiabetic efficacy of aerial parts A. orientalis extracts through digestive enzymes inhibition assay (?-amylase and ?-glucosidase), which are responsible for the digestion of poly and oligosaccharides. Acarbose, aqueous, and ethanolic extracts of A. orientalis were utilized in various concentrations (100, 200, 300, 400, and 500?g/ml). The absorbance values for the enzymes ?-amylase and ?-glucosidase at 540nm and 400nm, respectively, were measured using a spectrophotometer. Both extracts demonstrated significant inhibition of a-amylase and a-glucosidase enzymes in a dose-dependent manner. Furthermore, the ethanolic extract showed more inhibitory activity than the aqueous extract. In conclusion, A. orientalis extracts exhibited in vitro antidiabetic activity.
Cite this article:
Arwa R. Althaher. In vitro Assessment of the Antidiabetic Activity of Aqueous and Ethanolic Extracts from the Aerial Parts of Ajuga orientalis L.. Research Journal of Pharmacy and Technology 2023; 16(4):1828-2. doi: 10.52711/0974-360X.2023.00300
Cite(Electronic):
Arwa R. Althaher. In vitro Assessment of the Antidiabetic Activity of Aqueous and Ethanolic Extracts from the Aerial Parts of Ajuga orientalis L.. Research Journal of Pharmacy and Technology 2023; 16(4):1828-2. doi: 10.52711/0974-360X.2023.00300 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-4-49
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