Author(s):
Abdulhusein Mizhir Almaamuri, Ghassan Salah Ahmed, Falah Hassan Shari, Aiman Mohammed Baqir Al-Dhalimy, Haider Abdulkareem Almashhadani, Mustafa M. Kadhim
Email(s):
h_r200690@yahoo.com , haideralmashhdani@alrasheedcol.edu.iq
DOI:
10.52711/0974-360X.2023.00256 
Address:
Abdulhusein Mizhir Almaamuri1, Ghassan Salah Ahmed2, Falah Hassan Shari3, Aiman Mohammed Baqir Al-Dhalimy4,5, Haider Abdulkareem Almashhadani6, Mustafa M. Kadhim7,8
1Pharmacy Department, Al-Mustaqbal University College, Baghdad, Iraq.
2Department of Clinical Pharmacy, College of Pharmacy, University of Basrah, Iraq.
3Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basrah, Iraq.
4Department of Nursing, Altoosi University College, Najaf, Iraq.
5The Islamic University, Najaf, Iraq.
6Dentistry Department, Al-Rasheed University College, Iraq.
7Research Center, Kut University College, Kut, Wasit 52001, Iraq.
8Medical Laboratory Techniques Department, Al-Farahidi University, Iraq, Baghdad.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2023
ABSTRACT:
The extract of fig fruit has shown significant medical usefulness in various fields. The entrance of nanotechnology into the field of medicinal and pharmacology has shown remarkable advantages. Plants contain diverse molecules thatcan reduce metals, and provide a safe, eco-friendly approach for synthesizing nanoparticles. Iron oxide nanoparticles (IONPs) have been reported to possess an antimicrobial effect against some strains of bacteria and moulds. We have aimed to synthesize IONPs from fig fruit extract and investigate the influence of fig extract and IONPs in wound healing of mice. UV-Vis spectroscopy, X-ray diffraction (XRD), and field emission scanning electron microscopy were used to characterize the IONPs that were produced. The UV-Vis spectrum has indicated a maximum absorbance of around 400 nm, which is characterized by IONPs. The XRD examination has indicated the formation of a-Fe2O3 NPs, while the morphological examination by FESEM indicated the presence of aggregated rough IONPs. Then, 15 mice were divided into three groups equally; control, fig extract treated, and IONPs treated mice. Mice treated with fig extract or IONPs have shown obvious improvement after 5 days compared to control. On the 14th day, almost complete healing was observed in mice treated with fig fruit extract or IONPs. In conclusion, the possibility of using plants and NPs as antibacterial and anti-inflammatory agents would provide a great advancement in the administration of mild skin injuries.
Cite this article:
Abdulhusein Mizhir Almaamuri, Ghassan Salah Ahmed, Falah Hassan Shari, Aiman Mohammed Baqir Al-Dhalimy, Haider Abdulkareem Almashhadani, Mustafa M. Kadhim. The Wound Healing effect of the Green Synthesized Iron Oxide Nanoparticles: A Study on Mice. Research Journal of Pharmacy and Technology 2023; 16(4):1569-3. doi: 10.52711/0974-360X.2023.00256
Cite(Electronic):
Abdulhusein Mizhir Almaamuri, Ghassan Salah Ahmed, Falah Hassan Shari, Aiman Mohammed Baqir Al-Dhalimy, Haider Abdulkareem Almashhadani, Mustafa M. Kadhim. The Wound Healing effect of the Green Synthesized Iron Oxide Nanoparticles: A Study on Mice. Research Journal of Pharmacy and Technology 2023; 16(4):1569-3. doi: 10.52711/0974-360X.2023.00256 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-4-4
REFERENCES:
1. Mawa, S., K. Husain, and I. Jantan, Ficus carica L.(Moraceae): phytochemistry, traditional uses and biological activities. Evidence-Based Complementary and Alternative Medicine, 2013. 2013. https://doi.org/10.1155/2013/974256
2. Ravikumar, V., V. Gopal, and T. Sudha, Pharmacological studies of stem bark extracts of Zanthoxylum tetraspermum Wight and Arn.Res J Pharm Technol, 2012. 5: p. 5.
3. Jeong, W.S. and P. Lachance, Phytosterols and fatty acids in fig (Ficus carica, var. Mission) fruit and tree components. Journal of food science, 2001. 66(2): p. 278-281. https://doi.org/10.1111/j.1365-2621.2001.tb11332.x
4. Slatnar, A., et al., Effect of drying of figs (Ficus carica L.) on the contents of sugars, organic acids, and phenolic compounds. Journal of Agricultural and Food Chemistry, 2011. 59(21): p. 11696-11702. https://doi.org/10.1021/jf202707y
5. Veberic, R., J. Jakopic, and F. Stampar, Internal fruit quality of figs (Ficus carica L.) in the Northern Mediterranean Region. Italian Journal of Food Science, 2008. 20(2): p. 255-262.
6. Vinson, J.A., et al., Dried fruits: excellent in vitro and in vivo antioxidants. Journal of the American College of nutrition, 2005. 24(1): p. 44-50. https://doi.org/10.1080/07315724.2005.10719442
7. Vinson, J.A., The functional food properties of figs. Cereal foods world, 1999. 44(2): p. 82-87.
8. Vinson, J.A., et al., Phenol antioxidant quantity and quality in foods: vegetables. Journal of agricultural and food chemistry, 1998. 46(9): p. 3630-3634.https://doi.org/10.1021/jf980295o
9. AlMashhadani, H.A., Corrosion Protection of Pure Titanium Implant in Artificial Saliva by Electro-Polymerization of Poly Eugenol. Egyptian Journal of Chemistry, 2020. 63(8): p. 2-3.https://dx.doi.org/10.21608/ejchem.2019.13617.1842
10. Al-Saadie, K.A.S. and H.A.Y. AlMashhadani. Corrosion Protection of Pure Titanium Implant by Electrochemical Deposition of Hydroxyapatite Post-Anodizing. in IOP Conf. Series: Materials Science and Engineering. 2019.https://doi.org/10.1088/1757-899X/571/1/012071
11. Duke, J.A., Handbook of medicinal herbs. 2002: CRC press.
12. Almashhadani, H.A., et al., Corrosion inhibition behavior of expired diclofenac Sodium drug for Al 6061 alloy in aqueous media: Electrochemical, morphological, and theoretical investigations. Journal of Molecular Liquids, 2021. 343: p. 117656.https://doi.org/10.1016/j.molliq.2021.117656
13. Khazaal, F.A., et al., Electronic transfers and (NLO) properties predicted by ab initio methods with prove experimentally. NeuroQuantology, 2020. 18(1): p. 46.http://doi.org/10.14704/nq.2020.18.1.NQ20106
14. Penelope, O., Great natural remedies. Kyle Cathic, 1997.https://doi.org/10.23751/pn.v23i2.9980
15. Bura, A.R., Effect of Wound Healing Potential of Plumeria obtusa (Champa) Spray.Asian Journal of Pharmaceutical Research, 2018. 8(4): p. 231-235.http://dx.doi.org/10.5958/2231-5691.2018.00039.4
16. Rawat, S. and A. Gupta, Development and study of wound healing activity of an ayurvedic formulation. Asian J Res Pharm Sci, 2011. 1(1): p. 26-28.
17. Bernal, J., D. Dasgupta, and A. Mackay, The oxides and hydroxides of iron and their structural inter-relationships. Clay Minerals Bulletin, 1959. 4(21): p. 15-30.
18. Purohit, S., et al., Evaluation of wound healing activity of ethanolic extract of Curcuma longa rhizomes in male albino rats.Asian Journal of Pharmaceutical Research, 2013. 3(2): p. 79-81.
19. Sharma, R.K., et al., Assessment of wound healing activity of roots of Bauhinia variegata Linn. by excision and incision model in Albino Rats.Asian J Res Pharm Sci, 2015. 5(3): p. 145-52.https://doi.org/10.5958/2231-5659.2015.00023.5
20. Kamil, A.F., H.I. Abdullah, and S.H. Mohammed, Cibacron red dye removal in aqueous solution using synthesized CuNiFe2O5 Nanocomposite: thermodynamic and kinetic studies. Egyptian Journal of Chemistry, 2021. 64(11): p. 5-6.https://dx.doi.org/10.21608/ejchem.2021.66737.3437
21. Mohammed, S.H., et al., Green-synthesis of Platinum Nanoparticles using Olive Leaves Extracts and its Effect on Aspartate Aminotransferase Activity. Egyptian Journal of Chemistry, 2022. 65(4): p. 1-2.https://dx.doi.org/10.21608/ejchem.2021.91747.4355
22. Al Marjani, M., et al., Impact of Chromium Ooxide Nnanoparticles on gGrowth and bBiofilm fFormation of pPersistence Klebsiella pneumoniae iIsolates. Nano Biomed. Eng, 2021. 13(3): p. 321-327.
23. Abbas, Z.S., et al., Inhibition Effect of Copper (II) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease. Nano Biomed. Eng, 2021. 13(4): p. 364-371.
24. Mahdi, A., et al., Synthesis, characterization, spectroscopic, and biological activity studies of Nano scale Zn (II), Mn (II) and Fe (II) theophylline complexes.2020.
25. Patil, R.M., et al., Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles. Biochemistry and biophysics reports, 2018. 13: p. 63-72.https://doi.org/10.1016/j.bbrep.2017.12.002
26. Saif, S., A. Tahir, and Y. Chen, Green synthesis of iron nanoparticles and their environmental applications and implications. Nanomaterials, 2016. 6(11): p. 209.https://doi.org/10.3390%2Fnano6110209
27. Al-Mashhadani, H.A., et al. Anti-Corrosive Substance as Green Inhibitor for Carbon Steel in Saline and Acidic Media. in Journal of Physics: Conference Series. 2021. IOP Publishing.
28. AlMashhadani, H.A. and K.A. saleh, Electro-polymerization of poly Eugenol on Ti and Ti alloy dental implant treatment by micro arc oxidation using as Anti-corrosion and Anti-microbial.Research Journal of Pharmacy and Technology, 2020. 13(10): p. 4687-4696.https://doi.org/10.5958/0974-360X.2020.00825.2
29. Mohamad, N.A.N., et al., Plant extract as reducing agent in synthesis of metallic nanoparticles: a review. Advanced Materials Research, 2014. 832: p. 350-355.https://doi.org/10.4028/www.scientific.net%2FAMR.832.35
30. Demirezen, D.A., et al., Green synthesis and characterization of iron oxide nanoparticles using Ficus carica (common fig) dried fruit extract. Journal of bioscience and bioengineering, 2019. 127(2): p. 241-245.https://doi.org/10.1016/j.jbiosc.2018.07.024
31. Guo, L., et al., Iron nanoparticles: synthesis and applications in surface enhanced Raman scattering and electrocatalysis. Physical Chemistry Chemical Physics, 2001. 3(9): p. 1661-1665.https://doi.org/10.1039/B009951L
32. Ali, H.R., H.N. Nassar, and N.S. El-Gendy, Green synthesis of α-Fe2O3 using Citrus reticulum peels extract and water decontamination from different organic pollutants. Energy Sources, Part A: Recovery, Utilization, and Environmental Effects, 2017. 39(13): p. 1425-1434.https://doi.org/10.1080/15567036.2017.1336818
33. Lassoued, A., et al., Control of the shape and size of iron oxide (α-Fe2O3) nanoparticles synthesized through the chemical precipitation method. Results in physics, 2017. 7: p. 3007-3015.
34. Saravanan, R., et al., Evaluation of wound healing and anti microbial activity of the Argemone mexicana linn (papavraceae).Research Journal of Pharmacy and Technology, 2017. 10(6): p. 852-857.
35. Aksu Demirezen, D., et al., Green synthesis and characterization of iron oxide nanoparticles using Ficus carica (common fig) dried fruit extract. J Biosci Bioeng, 2019. 127(2): p. 241-245.
36. Mahdi, M.A., et al., Phytochemical content and anti-oxidant activity of hylocereus undatusand study of toxicity and the ability of wound treatment. Plant Archives, 2018. 18(2): p. 2672-2680.
37. Rajesh, B., et al., Phytochemical Analysis and Anti-arthritic Activity of Ficus carica Leaves.Asian Journal of Research in Chemistry,2020. 13(2): p. 151-154.https://doi.org/10.5958/0974-4150.2020.00030.9
38. Al-Ogaili, N.A., et al., In vitro antibacterial investigation and synergistic effect of Ficus carica and olea Europaea aqueous extracts.Res. J. Pharm. Technol,2020. 13: p. 1198-1203.https://doi.org/10.5958/0974-360X.2020.00221.8
39. Rath, G., et al., Development and characterization of cefazolin loaded zinc oxide nanoparticles composite gelatin nanofiber mats for postoperative surgical wounds. Materials Science and Engineering: C, 2016. 58: p. 242-253.https://doi.org/10.1016/j.msec.2015.08.050
40. Aziz, S.N., et al., Antibacterial, antibiofilm, and antipersister cells formation of green synthesis silver nanoparticles and graphene nanosheets against Klebsiella pneumoniae. Reviews in Medical Microbiology, 2022. 33(1): p. 56-63.https://doi.org/10.1002/jobm.201900511
41. Raguvaran, R., et al., Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells. International journal of biological macromolecules, 2017. 96: p. 185-191.https://doi.org/10.1016/j.ijbiomac.2016.12.009
42. Sudheesh Kumar, P., et al., Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. ACS applied materials & interfaces, 2012. 4(5): p. 2618-2629.https://doi.org/10.1021/am300292v
43. Gushcha, D., et al., The Study of Ni-Cr, Co-Cr Dental Alloys and Ceramics Chemical Indifference using ZrO 2-HfO 2-Y 2 O 3 System in Vitro.Research Journal of Pharmacy and Technology, 2019. 12(9): p. 4085-7089.https://doi.org/10.5958/0974-360X.2019.00703.0
44. Bansal, A., B. Pabla, and S. Vettivel, Effect of TIG Welding Process Parameters onTensile behavior of 5XXX and 6XXX series Aluminium Alloys: A Review.Research Journal of Engineering and Technology, 2018. 9(1): p. 1-8.https://doi.org/10.1016/j.mspro.2014.07.081