Greeshma B. Kotian, Mahalaxmi S. Petimani, Prabhakar Adake, Rahul Ramanujam, Afrah B. Kunjibettu
Greeshma B. Kotian1, Mahalaxmi S. Petimani2, Prabhakar Adake3, Rahul Ramanujam4*, Afrah B. Kunjibettu5
1Associate Professor of Biochemistry, AJ Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India.
2Associate Professor of Biochemistry, KAHER’s JGMM Medical College, Hubballi, Karnataka, India.
3Professor and Head, Department of Pharmacology, KAHER’s JGMM Medical College, Hubballi, Karnataka, India.
4Registrar, Department of Cardiology, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, Karnataka, India.
5Final year medical scholar, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, Karnataka, India.
Volume - 16,
Issue - 3,
Year - 2023
Title of the article: Analysis and correlation of small dense low-density lipoprotein-cholesterol (sdLDL-C) with various lipoproteins and cardiac markers in acute coronary syndrome patients associated with normal Low-density lipoprotein-cholesterol (LDL-C) level: A cross-sectional study. Aim: To analyze the levels of sdLDL cholesterol in acute coronary syndrome patients (ACS) with normal LDL cholesterol (LDL-C) and correlate with various lipoproteins and cardiac markers. Methodology: The present study included 100 patients diagnosed with ACS with normal LDL-C. Demographic details and cardiac markers were correlated with sdLDL levels. A detailed history was elicited from the patients and the details of clinical examination and laboratory findings such as cardiac Troponin, C- reactive protein, and CK-MB were obtained from patient case files. Results: The results are expressed in mean±sd. The mean age of study participants was 39.5±10.5yrs. The majority of the participants were men (69%) between the age group of 31-40 years. Mean values of total cholesterol, VLDL, sdLDL, Trop-I, CRP, and CKMB are at higher levels in men when compared to women. Whereas, mean values of triglycerides, LDL, and HDL are higher in women when compared to men. The majority of participants were having unstable angina (42%) followed by STEMI (33%) and NSTEMI (25%). Correlation between sdLDL and other parameters was carried out using Mann–Whitney–Wilcoxon test. The result showed a statistically significant correlation between sdLDL and VLDL, Trop-I, and CRP with p <0.05. Patients with sdLDL of > 25mg/dl had a higher incidence of unstable angina and STEMI. Conclusion: Our study result suggests that ACS with normolipidemic patients has a positive correlation with sdLDL levels and sdLDL can be a new diagnostic marker along with cardiac troponins in ACS.
Cite this article:
Greeshma B. Kotian, Mahalaxmi S. Petimani, Prabhakar Adake, Rahul Ramanujam, Afrah B. Kunjibettu. Analysis and correlation of small dense low-density lipoprotein-cholesterol (sdLDL-C) with various lipoproteins and cardiac markers in acute coronary syndrome patients associated with normal Low-density lipoprotein-cholesterol (LDL-C) level: A cross sectional study. Research Journal of Pharmacy and Technology 2023; 16(3):1214-8. doi: 10.52711/0974-360X.2023.00201
Greeshma B. Kotian, Mahalaxmi S. Petimani, Prabhakar Adake, Rahul Ramanujam, Afrah B. Kunjibettu. Analysis and correlation of small dense low-density lipoprotein-cholesterol (sdLDL-C) with various lipoproteins and cardiac markers in acute coronary syndrome patients associated with normal Low-density lipoprotein-cholesterol (LDL-C) level: A cross sectional study. Research Journal of Pharmacy and Technology 2023; 16(3):1214-8. doi: 10.52711/0974-360X.2023.00201 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-3-37
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