Author(s): Nozim N. Khoshimov, Alisher A. Mukhtorov, Kabil E. Nasirov, Rakhmatilla N. R, akhimov, Rahmatjon R. Mamadaminov

Email(s): , , , ,

DOI: 10.52711/0974-360X.2023.00200   

Address: Nozim N. Khoshimov1*, Alisher A. Mukhtorov2, Kabil E. Nasirov1, Rakhmatilla N. R
akhimov3, Rahmatjon R. Mamadaminov2
1Institute of Biophysics and Biochemistry at the National University of Uzbekistan. 2Namangan State University.
3The Institute of Bioorganic Chemistry named after A.S. Sadikov.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2023

Increasing amount of evidence suggests that age-related dysregulation of neuronal Ca2+ homeostasis may play a proximal role in the pathogenesis of Alzheimer's disease, as impaired Ca2+ can cause synaptic deficits and contribute to the accumulation of Aß plaques and neurofibrillary tangles.Ca2+ disruption is known to be mostly involved in all pathologies of Alzheimer's disease, the use of chemical agents or small molecules specific for Ca2+ channels, or the treatment of proteins on the plasma membrane and intracellular organelle membranes for correction is quite possible. Neuronal dysregulation of Ca2+ may open up a new approach to the prevention and treatment of Alzheimer's disease. The article shows the possible competition between the polyphenols P?-6, P?-7 and glutamate for the area of regulation of the opening of ion channels of ionotropic NMDA-receptors in the brain of rats.

Cite this article:
Nozim N. Khoshimov, Alisher A. Mukhtorov, Kabil E. Nasirov, Rakhmatilla N. R;akhimov, Rahmatjon R. Mamadaminov. Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate. Research Journal of Pharmacy and Technology 2023; 16(3):1205-3. doi: 10.52711/0974-360X.2023.00200

Nozim N. Khoshimov, Alisher A. Mukhtorov, Kabil E. Nasirov, Rakhmatilla N. R;akhimov, Rahmatjon R. Mamadaminov. Effects of Polyphenols on changes in the transport of Ca2+ NMDA-receptors under the influence of L-glutamate. Research Journal of Pharmacy and Technology 2023; 16(3):1205-3. doi: 10.52711/0974-360X.2023.00200   Available on:

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