Author(s): Devyani Diah Wulansari, Aguslina Kirtishanti, Reine Risa Risthanti, Devyana Dyah Wulandari, Lili Soetjipto, Dwi Winarni


DOI: 10.52711/0974-360X.2023.00192   

Address: Devyani Diah Wulansari1*, Aguslina Kirtishanti1, Reine Risa Risthanti2, Devyana Dyah Wulandari3, Lili Soetjipto4, Dwi Winarni5
1Department of Clinical and Community Pharmacy, Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia.
3Medical Laboratory Technologyst Study Program, Faculty of Health, Universitas Nahdlatul Ulama Surabaya, Surabaya, Indonesia.
4Faculty of Medicine, University of Surabaya, Surabaya, Indonesia.
5Faculty of Science and Technology, University of Airlangga, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2023

Background: Raw honey is a natural ingredient which has a variety of nutrients that can be used for alternative treatments for peptic ulcer disease. This study was carried out to examine the antiulcer effects of Raw Honey against Aspirin induced gastritis in rats. Methodology: Wistar rats were separated into 6 groups. Aspirin suspension 200mg/kgBW was given orally to groups 2-6 for 2 days. Then, group 1 and 2 received carboxymethylcellulose (CMC), groups 3-5 were orally forced-fed with 3.5, 7, and 14mL/kgBW of raw honey, and group 6 received 100mg/kgBW Cimetidine. The tested animals were killed after receiving therapy for 15 days and the gastric mucosa was observed macroscopically of the ulcer index and microscopically through histopathological preparations. The antioxidant effect of raw honey was identified from the lipid peroxidation marker (MDA). Conclusion : Treatment with 7 and 14 ml/kgBW of raw honey promotes gastric mucosal repair based on the macroscopic and microscopic observations. Significant decreases in the levels of the lipid peroxidation marker (MDA) was observed. Significance was defined as p<0.05 compared to the ulcer control group (Group 6).

Cite this article:
Devyani Diah Wulansari, Aguslina Kirtishanti, Reine Risa Risthanti, Devyana Dyah Wulandari, Lili Soetjipto, Dwi Winarni. Potential effect of Raw Honey on Gastric Mucosal Healing in Aspirin-induced Rats. Research Journal of Pharmacy and Technology 2023; 16(3):1153-0. doi: 10.52711/0974-360X.2023.00192

Devyani Diah Wulansari, Aguslina Kirtishanti, Reine Risa Risthanti, Devyana Dyah Wulandari, Lili Soetjipto, Dwi Winarni. Potential effect of Raw Honey on Gastric Mucosal Healing in Aspirin-induced Rats. Research Journal of Pharmacy and Technology 2023; 16(3):1153-0. doi: 10.52711/0974-360X.2023.00192   Available on:

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