Author(s): Shanti Bhushan Mishra, Mukul Maurya, Vineet Srivastava


DOI: 10.52711/0974-360X.2023.00187   

Address: Shanti Bhushan Mishra1*, Mukul Maurya2, Vineet Srivastava2
1Department of Pharmacognosy, United Institute of Pharmacy, Prayagraj 211010, India.
2Department of Pharmacology, United Institute of Pharmacy, Prayagraj 211010, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 3,     Year - 2023

The Neolamarcia cadamba plant has traditionally been claimed for the treatment of a variety of metabolic disorders, including diabetes. Many scientific studies have also proved its effectiveness against various diseases due to the presence of several chemical constituents viz. Quinovic Acid, Cadamabine, Cadambagenic Acid, Cadamine, Beta-Sitosterol, Chlorogenic Acid, etc. Therefore, in this study the effect of 50% ethanolic extract (NCEE) from the heartwood of the plant was evaluated for its potential antidiabetic, hypolipidemic and antioxidant effects in Streptozotocin (STZ) and high fat diet (HFD) induced diabetic rats. Preliminary phytochemical screening of NCEE revealed the presence of phenolic compounds, flavonoids, steroids and alkaloids. NCEE (200 and 400mg/kg body weight) was administered orally to diabetic rats, once daily for 3 weeks. Blood glucose levels, various biochemical parameters, antioxidant enzyme levels and histopathological investigation were performed in the diabetic control group and the extract treated groups. Plant extracts have a dose-dependent antidiabetic effect by normalizing the levels of antioxidant enzyme biomarkers and hematological abnormalities and ameliorating histopathological changes compared to the diabetic control group. The observations confirmed that the 50% ethanolic extract of heartwood of Neolamarckia cadamba (Roxb.) Bosser exhibits anti-diabetic, hypolipidemic effect along with mitigation of oxidative stress.

Cite this article:
Shanti Bhushan Mishra, Mukul Maurya, Vineet Srivastava. Heartwood Extract of Neolamarckia Cadamba Ameliorates Oxidative Stress Linked Type II Diabetes in Wistar Albino Rats. Research Journal of Pharmacy and Technology 2023; 16(3):1121-6. doi: 10.52711/0974-360X.2023.00187

Shanti Bhushan Mishra, Mukul Maurya, Vineet Srivastava. Heartwood Extract of Neolamarckia Cadamba Ameliorates Oxidative Stress Linked Type II Diabetes in Wistar Albino Rats. Research Journal of Pharmacy and Technology 2023; 16(3):1121-6. doi: 10.52711/0974-360X.2023.00187   Available on:

1.    American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009 Jan;32 Suppl 1(Suppl 1):S62-7.
2.    Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013 Mar 27;4:37.
3.    Chandiran Sharmila, Krishnamoorthy Renuka, Sorimuthu Pillai Subramanian. Biochemical Evaluation of Antidiabetic properties of Strychnos potatorum Seeds extract studied in High Fat Diet Fed- Low dose Streptozotocin induced experimental type 2 diabetes in Rats. Research J. Pharm. and Tech 2020; 13(6):2615-2623. doi: 10.5958/0974-360X.2020.00465.5
4.    Kirtikar KR, Basu BD. Indian medicinal plants., Allahabad: Lalit Mohan Basu publishers 1999.
5.    Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical ethnobotany of the Siddis of Uttara Kannada district, Karnataka, India. J Ethnopharmacol. 1995 Jul 28;47(3):149-58.
6.    Umachigi SP, Kumar GS, Jayaveera K, Kishore KD, Ashok KC, Dhanapal R. Antimicrobial, wound healing and antioxidant activities of Anthocephalus cadamba. Afr J Tradit Complement Altern Med. 2007 Jun 10;4(4):481-7.
7.    Kapil A, Koul IB, Suri OP. Antihepatotoxic Effects of chlorogenic acid from Anthocephalus cadamba. Phytother Res. 1995 May; 9(3):189-93.
8.    RS Bachhav, VV Buchake, RB Saudagar. Analgesic and Anti-Inflammatory Activities of Anthocephalus Cadamba Roxb. Leaves in Wistar Rats. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 164- 167
9.    Chander Hass, Parveen Kumar, Dheeraj Rajak, S.K. Jain, Manish M. Wanjari. Evaluation of Analgesic and Anti-inflammatory Activity of Bark of Neolamarckia cadamba in Rodents. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1178-1184
10.    Rahul Kaushik, Jainendra Jain, Pallavi Rai, Yogesh Sharma, Virender Kumar, Akanksha Gupta. Pharmacognostical, Physicochemical and Preliminary Phytochemical studies of Anthocephalus cadamba (Roxb.) Leaves. Research J. Pharm. and Tech 2018; 11(4): 1391-1397. doi: 10.5958/0974- 360X.2018.00260.3
11.    Manish Devgan, Lovkesh Bhatia, Hitesh Kumar. Anthocephalus cadamba: A Comprehensive Review. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1577-1584
12.    Prajapati ND, Purohit SS, Sharma AK, Kumar TA. Handbook of medicinal plants: A complete source book. Jodhpur: Agrobios (India) publisher, 2006.
13.    Dwevedi A, Sharma K, Sharma YK. Cadamba: A miraculous tree having enormous pharmacological implications. Pharmacogn Rev. 2015 Jul-Dec;9(18):107-13.
14.    OECD Guideline for testing of chemicals. Acute oral toxicity-acute toxic class method, guideline no. 423. Organization for Economic Cooperation and Development, Rome 2001.
15.    Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low- dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res. 2005 Oct;52(4):313-20.
16.    Mishra SB, Verma A, Vijayakumar M. Preclinical evaluation of antihyperglycemic and antioxidant action of Nirmali (Strychnos potatorum) seeds in streptozotocin nicotinamide induced diabetic Wistar rats: a histopathological investigation. Biomark Genom Med. 2013; 5(4): 157–63.
17.    Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 2014;11(11):1185–1200.
18.    Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, Reaven GM. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism: clinical and experimental 2000; 49(11): 1390–1394
19.    Mahadeva Rao U.S., S Akbar Kausar, R. Babu Janarthanam, Sinouvassane Djearamane, S. Suresh Kumar. Biochemical Evaluation of Antidiabetic Effect of Kasini ashshifa, a Polyherbal formulation in High Fat Diet Fed- Low Dose STZ Induced Diabetes in Rats. Research J. Pharm. and Tech 2020; 13(3):1474-1482. doi: 10.5958/0974-360X.2020.00269.3
20.    Erhirhie EO, Ihekwereme CP, Ilodigwe EE. Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance. Interdiscip Toxicol. 2018 May;11(1):5-12. 2018-0001
21.    Eid HM, Haddad PS. The Antidiabetic Potential of Quercetin: Underlying Mechanisms. Curr Med Chem. 2017;24(4):355-364.
22.    Rehman K, Chohan TA, Waheed I, Gilani Z, Akash MSH. Taxifolin prevents postprandial hyperglycemia by regulating the activity of α-amylase: Evidence from an in vivo and in silico studies. J Cell Biochem. 2019 Jan;120(1):425-438.
23.    Czech MP. Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 2017 Jul 11;23(7):804- 814.
24.    Vadivelan R, Dhanabal SP, Raja Rajeswari, Shanish A, Elango K, Suresh B. Oxidative Stress in Diabetes- A Key Therapeutic Agent. Research J. Pharmacology and Pharmacodynamics. 2010; 2(3): 221-227.
25.    Sofia Khanam, Firdous SM. Morin combat against Oxidative stress induced different diseases in Experimental models: A Review. Research J. Pharm. and Tech 2020; 13(9):4522- 4526. doi: 10.5958/0974-360X.2020.00797.0
26.    Tiedge M, Lortz S, Munday R, Lenzen S. Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species. Diabetes. 1998 Oct;47(10):1578-85.
27.    Sukhpal Singh, Amita Mahajan, Jaspreet Kaur. Studies on Status of Oxidative Stress related Molecules and Enzymes in Obese with and without Diabetes in the Northern region of India. Research J. Pharm. and Tech 2020; 13(2):801-809. doi: 10.5958/0974-360X.2020.00151.1

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available