Naga Raju Kandukoori, Narsimha Reddy Yellu
Naga Raju Kandukoori1, Narsimha Reddy Yellu2*
1Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal (V), Ranga Reddy (D), Hyderabad, Telangana, India.
2University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana – India.
Volume - 16,
Issue - 3,
Year - 2023
The Cytochrome P-450 (CYP) enzymes present in the human body are responsible for the metabolism of most antidiabetic drugs. These CYP enzymes may metabolize the drugs either to active metabolites or to inactive metabolites. Some phytoconstituents which are present in vegetables, fruits and ayurvedic products will alter the activity of CYP enzymes. In the present research, the alterations in pharmacokinetics and pharmacodynamics of Nateglinide in the presence of a phytochemical like Capsaicin were studied. The study was conducted both in normal and diabetic rats. Rats were divided into different groups. Drug was administered as alone in one group and administered in combination with Capsaicin to other groups. After 8 days of treatment, the blood samples were collected and analysed. The Pharmacokinetic parameters like Cmax, tmax, AUC, MRT, Vd and ClT were estimated for all groups and compared. The mean blood glucose levels before and after treatments were recorded and compared among the groups. From the results, it could be concluded that the Capsaicin has inhibited the activity of CYP 2C9 and CYP 3A4 enzymes, thereby decreased the metabolism of drug which ultimately resulted in the increase of Cmax and AUC. The Capsaicin could raise the antidiabetic effect of drug.
Cite this article:
Naga Raju Kandukoori, Narsimha Reddy Yellu. Effect of Capsaicin on Pharmacokinetics and Pharmacodynamics of Nateglinide in normal and diabetic rats. Research Journal of Pharmacy and Technology 2023; 16(3):991-6. doi: 10.52711/0974-360X.2023.00165
Naga Raju Kandukoori, Narsimha Reddy Yellu. Effect of Capsaicin on Pharmacokinetics and Pharmacodynamics of Nateglinide in normal and diabetic rats. Research Journal of Pharmacy and Technology 2023; 16(3):991-6. doi: 10.52711/0974-360X.2023.00165 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-3-1
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