Santhosh S, Pazhani GP, Arathi MS, Manickam S
Santhosh S1, Pazhani GP2, Arathi MS3, Manickam S4*
1Scholar, Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam – 603103, Tamil Nadu, India.
2Associate Professor, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulattur – 603203, Tamil Nadu, India.
3Associate Professor, Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam – 603103, Tamil Nadu, India.
4 Associate Professor, Department of Anatomy, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam – 603103, Tamil Nadu, India.
Volume - 16,
Issue - 2,
Year - 2023
The herb Boerhavia diffusa (BD) is well-known in the Indian medicinal system. Punarnava is its vernacular name. BD is one of the chief ingredients in ayurvedic formulations used for urinary diseases. In the realm of phytochemistry, the plant has risen to prominence due to its diverse biological activities. Here, we reviewed the scientific literature available on administration of BD for acute kidney injury, chronic kidney disease, polycystic kidney disease, renal calculi, urinary tract infection, and COVID-19 related kidney disease and we also explored its antioxidant and anti-inflammatory properties. The nephroprotective effect of BD has been clearly demonstrated in in vitro, in vivo, and in clinical studies. The in vivo studies have yielded a plethora of data. The most commonly employed extracts were aqueous, hydroalcoholic, ethanolic, and methanolic extracts. Clinical studies have employed polyherbal combinations containing BD extract. Irrespective of the type of BD extract, all studies showed reduction in the key markers of kidney diseases, namely urea, creatinine, BUN, and proteins. It has antifibrotic property reducing the formation of extracelluar collagen deposition in the renal tubules, which is not much explored. The review highlights the importance of further research required in establishing the molecular mechanisms underlying the action of BD. With in-depth molecular research and clinical trials, BD could be developed into a novel therapeutic agent for the successful treatment of renal disorders especially the chronic kidney disease.
Cite this article:
Santhosh S, Pazhani GP, Arathi MS, Manickam S. Nephroprotective Role of Boerhavia diffusa in Renal Disorders: A Review. Research Journal of Pharmacy and Technology 2023; 16(2):962-8. doi: 10.52711/0974-360X.2023.00161
Santhosh S, Pazhani GP, Arathi MS, Manickam S. Nephroprotective Role of Boerhavia diffusa in Renal Disorders: A Review. Research Journal of Pharmacy and Technology 2023; 16(2):962-8. doi: 10.52711/0974-360X.2023.00161 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-2-80
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