Author(s): Pawan Tiwari, Gurdeep Singh, Ritesh Patel, Mukesh Kr. Singh

Email(s): pawan786pharma@gmail.com

DOI: 10.52711/0974-360X.2023.00118   

Address: Pawan Tiwari1*, Gurdeep Singh2, Ritesh Patel3, Mukesh Kr. Singh4
1Department of Pharmaceutical Chemistry, Shambhunath Institute of Pharmacy, Prayagraj U.P., India.
2School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
3Department of Pharmaceutical Chemistry, Indore Institute of Pharmacy, Indore, M.P., India.
4School of Pharmaceutical Sciences, IFTM University, Moradabad, U.P., India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023


ABSTRACT:
Natural products are essential to human life, and about half of the medications used in clinical practice today are of natural origin. The present work investigated to isolate and identify active compounds with anti-diabetic activity from Scindapsus officinalis fruits and confirm the isolated compounds' mode of action, affinity, and domain specificity relationships. Some fractions of S. officinalis ethanolic extracts were subjected to column chromatography and preparative TLC and two compounds namely 2E,4E,6E)-5-methyl-7-(2,6,6-trimethylcyclohexa-2,4-dien-1-yl)hepta-2,4,6-trien-1-ol (CN-501A) and 9-(furan-3-yl)-4-hydroxy-1,5,6,6a,9,10,10a,10b-octahydro-3H,7H-pyrano[3,4-f]isochromene-3,7-dione (CN-501B) were isolated in pure form. The structures of the isolated compounds were confirmed by UV, IR, 1H NMR and mass spectral data. The anti diabetic activity was measured using a molecular docking study and the three-dimensional structure of the target protein was downloaded from PDB. The Docking study recommended that CN – 501A and CN – 501B are existing photochemical from the plant of S. officinalis had the highest fitness docking score and hence could be a possible antidiabetic drug.


Cite this article:
Pawan Tiwari, Gurdeep Singh, Ritesh Patel, Mukesh Kr. Singh. Isolation, Characterization and Docking Studies of Isolated Compounds as Antidiabetic Molecules from Scindapsus officinalis (Roxb). Research Journal of Pharmacy and Technology 2023; 16(2):691-7. doi: 10.52711/0974-360X.2023.00118

Cite(Electronic):
Pawan Tiwari, Gurdeep Singh, Ritesh Patel, Mukesh Kr. Singh. Isolation, Characterization and Docking Studies of Isolated Compounds as Antidiabetic Molecules from Scindapsus officinalis (Roxb). Research Journal of Pharmacy and Technology 2023; 16(2):691-7. doi: 10.52711/0974-360X.2023.00118   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-2-37


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