ABSTRACT:
According to the World Health Organization, chronic liver diseases account for approximately 46% of all diseases and 59% of all deaths worldwide. It is critical to look for hepatoprotective crucial findings because they are important for human health. The aim of this study was to compare the hepatoprotective activity of six medicinal plants based on biochemical reduction on the animal study. The increased levels of ALT, AST, ALP, total bilirubin, direct bilirubin, and cholesterol in the blood have been marked to the damaged structural virtue of the liver. When the plant extract was given to rats after they were administered a hepatotoxicant and the level of marker enzymes was discovered to be lower than normal, it meant that the particular dose of the plant extract was considerably supporting the hepatoprotective action. The comparative study of hepatoprotective efficacy of six medicinal plants was determined by a biostatistical analysis of data received from an animal investigation. The Terminalia coriacea and Artocarpus hirsutus at 250 and 500mg/kg respectively revealed that the *P<0.05; **P< 0.01; ***P<0.001; when compared to the CCl4 group. The Cucumis melo revealed P<0.05 and P<0.01 as compared with the liver-damaged control to the drug-treated animal at doses of 100, 250, and 500mg/kg. Buchanania lanzan revealed significant at P<0.05*, 0.01** and 0.001*** at 100 mg/kg, 200mg/kg and 400 mg/kg for aqueous and alcoholic extract both. The Diospyros melanoxylon (Roxb) and Solanum americanum Mill at doses 100, 200, and 400 mg/kg and 200, 400, and 600 mg/kg respectively. The T. coriacea and A. hirsutus revealed a 5%, 1%, and less than 1% chance of false-positive, which is statistically significant at all levels.