Author(s): Seemitr Verma, Ruchee Khanna, Vishwapriya Godkhindi, Anjali Vijay S, Shashidhar V, S M Zeeshan

Email(s): seemitr.verma@manipal.edu , ruchee.khanna@manipal.edu , vishwapriya.mg@manipal.edu , anjali.vijay@manipal.edu , shashidhar.v@manipal.edu , sayed.zeeshan@vitbhopal.ac.in

DOI: 10.52711/0974-360X.2023.00083   

Address: Seemitr Verma*1, Ruchee Khanna2, Vishwapriya Godkhindi3, Anjali Vijay S4, Shashidhar V5, S M Zeeshan6
1Assistant Professor (MD Pathology), Dept. of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka.
2Associate Professor (MD Pathology), Dept. of Pathology, Kasturba Medical College, Manipal. Manipal Academy of Higher Education, Manipal, Karnataka.
3Assistant Professor (MD Pathology), Dept. of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka.
4Assistant Professor (MD Pathology), Dept. of Pathology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka.
5Professor (MD Microbiology), Dept. of Microbiology, Kasturba Medical College, Manipal. Manipal Academy of Higher Education, Manipal, Karnataka.
6Assistant Professor (M.Sc. PhD), Dept. of Statistics, VIT University, Bhopal, Madhya-Pradesh.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023


ABSTRACT:
Introduction: We started this study with a research question that whether prolonged APTT, prolonged PT and decreased platelet counts have any correlation with the patients having HIV, as compared to normal healthy controls and also do these changes go hand in hand with the level of CD4 count thus reflecting disease progression. We look for an answer to the question that, can these coagulation parameters be included in the routine testing and care of the HIV patients? Does the treatment have an effect on these parameters? Aims and Objectives: 1) To evaluate PT, APTT, and platelet count of HIV patients and compare them with normal healthy controls. 2) To analyse these parameters with respect to their CD4 count. Conclusion: In the present study the mean APTT value was prolonged which was statistically significant when compared to normal healthy controls. The mean PT value was not prolonged and the difference between HIV patients and controls was not statistically significant. Mean platelet count was not decreased, but the difference was statistically significant when compared to normal controls. The difference in mean APTT, PT and platelet count was not statistically significant when patients with CD4 count <200cell/mm3 were compared with those having CD4 count >200cells/mm3. Hence these parameters cannot be used for disease monitoring.


Cite this article:
Seemitr Verma, Ruchee Khanna, Vishwapriya Godkhindi, Anjali Vijay S, Shashidhar V, S M Zeeshan. Study of Coagulation parameters in HIV patients and its relation to CD4 counts and ART status. Research Journal of Pharmacy and Technology 2023; 16(2):489-4. doi: 10.52711/0974-360X.2023.00083

Cite(Electronic):
Seemitr Verma, Ruchee Khanna, Vishwapriya Godkhindi, Anjali Vijay S, Shashidhar V, S M Zeeshan. Study of Coagulation parameters in HIV patients and its relation to CD4 counts and ART status. Research Journal of Pharmacy and Technology 2023; 16(2):489-4. doi: 10.52711/0974-360X.2023.00083   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-2-2


REFERENCES:
1.    Mahy M, Marsh K, Sabin K, Wanyeki I, Daher J, Ghys PD. HIV estimates through 2018: data for decision-making. AIDS [Internet]. 2019 Dec 12;33(Suppl 3):S203. doi: 10.1097/QAD.0000000000002321
2.    Sahu D, Kumar P, Chandra N, Rajan S, Shukla D, Venkatesh S, et al. Findings from the 2017 HIV estimation round & trend analysis of key indicators 2010-2017: Evidence for prioritising HIV/AIDS programme in India. Indian J Med Res [Internet]. 2020 Jun 1;151(6):562–70. doi: 10.4103/ijmr.IJMR_1619_19
3.    Arumugam E, David JK, Aridoss S, Jaganathasamy N, Mathiyazhakan M, Balasubramanian G, et al. An Analysis of Levels and Trends in HIV Prevalence Among Pregnant Women Attending Antenatal Clinics in Karnataka, South India, 2003-2019. Int J Matern Child Heal AIDS [Internet]. 2021 Nov 1;10(2):198. doi: 10.21106/ijma.520
4.    Bhatta M, Dutta N, Nandi S, Dutta S, Saha MK. Mother-to-child HIV transmission and its correlates in India: Systematic review and meta-analysis. BMC Pregnancy Childbirth [Internet]. 2020 Sep 4;20(1):1–15. doi.org/10.1186/s12884-020-03193-3
5.    Misao H, Lamare I, Rhetso M, Rana ND, Chyne P, Humtsoe YZ. Knowledge and attitude towards HIV/AIDS among undergraduate students. Asian J Nurs Educ Res [Internet]. 2020 Apr 23;10(2):189–93. doi: 10.5958/2349-2996.2020.00041.5
6.    Patel S, Patidar K. A Study to Assess the Effectiveness of Self Instructional Module on Knowledge Regarding HIV/AIDS among the Barbers in Mehsana City. Asian J Nurs Educ Res. 2017 Aug;7(3):281–3. doi: 10.5958/2349-2996.2017.00058.1
7.    Juliet Sylvia1*, Dr. Basavanthappa2 DR. A Study to Compare and Correlate the Knowledge and Attitude Regarding HIV/AIDS among Young Married and Unmarried Women in Selected Urban Slums of Madurai, Tamil Nadu. Asian J Nur Edu Res. 2012;2(3):118–25. doi: 10.5958/2349-2996
8.    Merlin A. A Study to Assess the Knowledge Regarding HIV/AIDS Among Young Adults in Selected Areas, Mumbai. Int J Nurs Educ Res. 2021 Dec;9(4):467–8. doi: 10.52711/2454-2660.2021.00107
9.    Maheshwari P, Sunny M. A Prospective Study on the Knowledge, Attitude and Perception on HIV/AIDS among the Nursing and other Healthcare Professionals. Res J Pharm Technol. 2016 Sep;9(9):1403–8. doi: 10.5958/0974-360X.2016.00271.7
10.    Thulasi Raman R, Manimaran D, Rachakatla P, Bharathi K, Afroz T, Sagar R. Study of basic coagulation parameters among HIV patients in correlation to CD4 counts and ART status. J Clin Diagnostic Res. 2016;10(5):EC04–6. doi: 10.7860/JCDR/2016/17459.7718
11.    Shankar SS, Dubé MP. Clinical aspects of endothelial dysfunction associated with human immunodeficiency virus infection and antiretroviral agents. Cardiovasc Toxicol. 2004;4(3):261–9. doi.org/10.1385/CT:4:3:261
12.    Bibas M, Biava G, Antinori A. HIV-associated venous thromboembolism. Mediterr J Hematol Infect Dis. 2011;3(1). doi: 10.4084/MJHID.2011.030
13.    Shen YMP, Frenkel EP. Thrombosis and a hypercoagulable state in HIV-infected patients. Clin Appl Thromb. 2004 Jul;10(3):277–80. doi: 10.1177/107602960401000311
14.    Wasif Saif H, Greenberg B. HIV and thrombosis: A review. AIDS Patient Care STDS. 2001;15(1):15–24. doi: 10.1089/108729101460065
15.    WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children [Internet]. Available from: https://apps.who.int/iris/handle/10665/43699
16.    Seyoum M, Enawgaw B, Getaneh Z, Engidaye G, Asrie F, Melku M. Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study. Biomed Res Int. 2018;2018. doi: 10.1155/2018/5320827
17.    Nasir IA, Owolagba A, Ahmad AE, Barma MM, Musa PO, Bakare M, et al. Effects of first-line anti-retroviral therapy on blood coagulation parameters of HIV-infected patients attending a tertiary hospital at Abuja, Nigeria. Malays J Pathol. 2016;38(2):103–9. doi: 10.1371/journal.pone.0174233
18.    Jong E, Meijers JCM, van Gorp ECM, Spek CA, Mulder JW. Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir. AIDS Res Ther. 2010;7:3–9. doi: 10.1186/1742-6405-7-9
19.    Tene L, Tagny CT, Mintya-Ndoumba A, Fossi VN, Mbanya D. Haemostatic trends in HIV-infected individuals in Yaoundé, Cameroon: A pilot study. Blood Coagul Fibrinolysis. 2014;25(5):422–5. doi: 10.1097/MBC.0000000000000066
20.    Baker J V. Chronic HIV disease and activation of the coagulation system. Vol. 132, Thrombosis Research. Elsevier Ltd; 2013. p. 495–9. doi: 10.1016/j.thromres.2013.08.016
21.    Omoregie R1, Osakue SI, Ihemeje V, Omokaro EU OH. Correlation of CD4 count with platelet count, prothrombin time and activated partial thromboplastin time among HIV patients in Benin City, Nigeria. West Indian Med J. 2009;5(Nov 58):437–40. doi: 10.1155/2022/6782595
22.    MO I, Sylvester N I. Activated Partial Thromboplastin Time, Prothrombin Time, Thrombin Time and Platelet Count Study in HIV Seropositive Subjects at Nnamdi Azikiwe Teaching Hospital Nnewi. Transl Biomed. 2016;7(2):5–9. doi: 10.21767/2172-0479.100063
23.    Leticia OI, Ugochukwu A, Ifeanyi OE, Andrew A, Ifeoma UE. The Correlation of Values of Cd4 Count, Platelet, Pt, Aptt, Fibrinogen and Factor VIII Concentrations among HIV Positive Patients in FMC Owerri. Vol. 13, IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN. 2014. doi:10.9790/0853-139294101
24.    Sylvia J. A Care Map for a Youth Friendly Reproductive and Sexual Health Services (YFRSHS) For HIV/ Aids Prevention. Int J Adv Nurs Manag [Internet]. 2015 Sep 28;3(3):283–8. Available from: https://ijanm.com/AbstractView.aspx?PID=2015-3-3-17. doi: 10.5958/2454-2652.2015.00017.7

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