Author(s): Zamroni Afif, Mochammad Istiadjid Eddy Santoso, Husnul Khotimah, Irawan Satriotomo, Edi Widjajanto, Masruroh Rahayu, Sri Budhi Rianawati, Shahdevi Nandar Kurniawan, Rodhiyan Rakhmatiar, Dheka Sapti Iskandar, Annisatul Hakimah, Syafiatul Azizah, Nurvia Andriani, Kartika Agustina

Email(s): husnul_farmako.fk@ub.ac.id

DOI: 10.52711/0974-360X.2023.00100   

Address: Zamroni Afif1, Mochammad Istiadjid Eddy Santoso1, Husnul Khotimah2*, Irawan Satriotomo3, Edi Widjajanto4, Masruroh Rahayu5, Sri Budhi Rianawati5, Shahdevi Nandar Kurniawan5, Rodhiyan Rakhmatiar5, Dheka Sapti Iskandar6, Annisatul Hakimah6, Syafiatul Azizah6, Nurvia Andriani7, Kartika Agustina7
1Doctoral Program, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
2Departement of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
3Indonesian Neuroscience Institute, Indonesia.
4Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
5Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
6Master Program Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
7Residency Program, Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023


ABSTRACT:
Insomnia is a difficulty to start sleeping or maintaining the quality of sleep. The latest concept of insomnia explains the disintegration of molecules that change the brain’s rhythm of waking and sleeping. Neurotransmitters that stimulate awakening are orexin, histamine, dopamine, serotonin, while those responsible for sleeping are ?-aminobutyric acid (GABA), adenosine, serotonin, melatonin, and prostaglandin D2 (PGD2). Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) pathways have a role in various neuroplasticity that also a candidate mechanism that plays a role in sleep plasticity regulation. Centella Asiatica (CA) is a herb which neuroprotectant effect on neurological diseases. CA can provide anti-inflammatory and rejuvenating effects, antioxidant, anxiolytic, stress relief, and improve intelligence. CA has a role in signaling MAPK/ERK pathway. MAPK3 (ERK1) and MAPK1 (ERK2) proteins are targets that are binded by beta-carotene from CA. In this study, based on QSAR analysis, it proved that CA has benefits for insomnia treatment, as ICAM1 expression inhibitor (0.55), nitric oxide antagonist (0.67), anti-inflammatory (0.80), and gastrin inhibitor (0.45). Therefore, it can be predicted that CA can potentially inhibit ICAM-1 and target AKT1 protein. Then, based on molecular docking, Protein Compound Interaction (PCI) results prove that beta carotene is the most potent MAPK1 inhibitor.


Cite this article:
Zamroni Afif, Mochammad Istiadjid Eddy Santoso, Husnul Khotimah, Irawan Satriotomo, Edi Widjajanto, Masruroh Rahayu, Sri Budhi Rianawati, Shahdevi Nandar Kurniawan, Rodhiyan Rakhmatiar, Dheka Sapti Iskandar, Annisatul Hakimah, Syafiatul Azizah, Nurvia Andriani, Kartika Agustina. Centella asiatica improved Insomnia through MAPK/ERK Signaling Pathway: In Silico Study. Research Journal of Pharmacy and Technology 2023; 16(2):587-2. doi: 10.52711/0974-360X.2023.00100

Cite(Electronic):
Zamroni Afif, Mochammad Istiadjid Eddy Santoso, Husnul Khotimah, Irawan Satriotomo, Edi Widjajanto, Masruroh Rahayu, Sri Budhi Rianawati, Shahdevi Nandar Kurniawan, Rodhiyan Rakhmatiar, Dheka Sapti Iskandar, Annisatul Hakimah, Syafiatul Azizah, Nurvia Andriani, Kartika Agustina. Centella asiatica improved Insomnia through MAPK/ERK Signaling Pathway: In Silico Study. Research Journal of Pharmacy and Technology 2023; 16(2):587-2. doi: 10.52711/0974-360X.2023.00100   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-2-19


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