Author(s):
Nishmitha D. Shetty, Deepa G. Kamath, Neetha J. Shetty
Email(s):
deepa.gkamath@manipal.edu
DOI:
10.52711/0974-360X.2023.00991 
Address:
Nishmitha D. Shetty1, Deepa G. Kamath2, Neetha J. Shetty3
1Department of Periodontology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka 575001.
2Department of Periodontology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka 575001.
3Department of Periodontology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka 575001.
*Corresponding Author
Published In:
Volume - 16,
Issue - 12,
Year - 2023
ABSTRACT:
Periodontal diseases are chronic infectious illnesses that have become a significant burden on oral health. Several new treatment targets have been found because of advances in the study of the epidemiology, aetiology, and pathophysiology of periodontitis, as well as the analysis of the polymicrobial interaction in the oral bacterial communities. Efforts to limit growth of bacteria and the formation of substances that eventually damage the tissues supporting the teeth have been the foundation of periodontal therapy. Systemic antibiotic administration for periodontitis has significant shortcomings, attracting attentiontowards the advancement of localized drug delivery systems capable ofmaintaining effective antibiotic concentrations at the intended site throughout the course of treatment with minimum side effects. A controlled release system that can be placed within the periodontal pocket so as to extend therapeutic concentrations at the desired site at a considerably lesser dosage is a pressing priority. Chitosan, a potential carbohydrate biopolymer, is receiving scientific interest in a diverse range of biomedical fields due to its exceptional chemical and pharmacokinetic attributes. Chitosan is a biocompatible and biodegradable naturally occurring polysaccharide with several uses in dentistry owing to its functional versatility and easy accessibility. The applications of chitosan are vast, exciting, and still unexplored. Thisreviewfocusesonthe potential uses of chitosan in periodontology.
Cite this article:
Nishmitha D. Shetty, Deepa G. Kamath, Neetha J. Shetty. Chitosan- A Promising agent for site specific drug delivery in periodontics. Research Journal of Pharmacy and Technology.2023; 16(12):6105-9. doi: 10.52711/0974-360X.2023.00991
Cite(Electronic):
Nishmitha D. Shetty, Deepa G. Kamath, Neetha J. Shetty. Chitosan- A Promising agent for site specific drug delivery in periodontics. Research Journal of Pharmacy and Technology.2023; 16(12):6105-9. doi: 10.52711/0974-360X.2023.00991 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-12-92
REFERENCES:
1. Vyas SP, Sihorkar V, Mishra V. Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. J Clin Pharm Ther. 2000; 25(1): 21–42. doi: 10.1046/j.1365-2710.2000.00261.x.
2. Zimmerman SO. Discussion: Attachment level changes in destructive periodontal diseases. J Clin Periodontol. 1986; 13(5): 473–5. doi: 10.1111/j.1600-051x.1986.tb01491.x.
3. Jain N, Jain GK, Javed S, Iqbal Z, Talegaonkar S, Ahmad FJ, et al. Recent approaches for the treatment of periodontitis. Drug Discov Today. 2008; 13(21–22): 932–43. doi: 10.1016/j.drudis.2008.07.010.
4. Walker CB, Gordon JM, Cornwall HA, Murphy JC, Socransky SS. Gingival crevicular fluid levels of clindamycin compared with its minimal inhibitory concentrations for periodontal bacteria. Antimicrob Agents Chemother. 1981; 19(5): 867–71.doi: 10.1128/aac.19.5.867
5. Slots J, Rams TE. Antibiotics in periodontal therapy: advantages and disadvantages. J Clin Periodontol. 1990;17(7):479-93. doi: 10.1111/j.1365-2710.1992.tb01220.x.
6. Williams KR, Blayney AW. Tissue response of several polymeric materials implanted in the rat middle ear. Biomaterials. 1987; 8(4): 254–8. doi: 10.1016/0142-9612(87)90112-8.
7. Hall EE, Meffert RM, Hermann JS, Mellonig JT, Cochran DL. Comparison of Bioactive Glass to Demineralized Freeze-Dried Bone Allograft in the Treatment of Intrabony Defects Around Implants in the Canine Mandible. J Periodontol. 1999; 70(5): 526–35. doi: 10.1902/jop.1999.70.5.526.
8. Jain V, Garg G, Patil UK, Jain S. Recent Perspectives of Chitosan : A Review. 2010; 2(3): 220–4.
9. Gokilavani S, Vijayabharathi V, Parthasarathy R. Physico-Chemical Characteristics and Antibacterial Activity of Chitosan Extracted from Shell of Crab Paratelphusa hydrodromous. 2014; 4(3): 125–8.
10. Aguilar A, Zein N, Harmouch E, Hafdi B, Bornert F, Damien O, et al. Biodental Engineering V. Biodental Eng V. 2019; 1–17. doi: 10.3390/molecules24163009
11. Lestari W, Yusry WNAW, Haris MS, Jaswir I, Idrus E. A glimpse on the function of chitosan as a dental hemostatic agent. Jpn Dent Sci Rev. 2020; 56(1): 147–54. https://doi.org/10.1016/j.jdsr.2020.09.001
12. Tarsi R, Muzzarelli RAA, Guzmàn CA, Pruzzo C. Inhibition of Streptococcus mutans adsorption to hydroxyapatite by low-molecular-weight chitosans. J Dent Res. 1997; 76(2): 665–72. doi: 10.1177/00220345970760020701.
13. Prakash S, Vandana K V, Sarkar S. Antimicrobial Efficacy of 1% Chitosan Gel against Periodontal Pathogens: An In Vitro Study. CODS J Dent. 2021; 12(2): 31–4. https://doi.org/10.5005/jp-journals-10063-0060
14. Kmiec M, Pighinelli L, Tedesco MF, et al. Chitosan-Properties and Applications in Dentistry. Adv Tissue Eng Regen Med Open Access. 2017; 2(4): 205–211. DOI: 10.15406/atroa.2017.02.00035
15. Mohire NC, Yadav A V. Chitosan-based polyherbal toothpaste: As novel oral hygiene product. Indian J Dent Res. 2010; 21(3): 380–4. doi: 10.4103/0970-9290.70808.
16. Klokkevold PR, Newman MG. Current status of dental implants: a periodontal perspective. Int J Oral Maxillofac Implants. 2015; 15(1): 56–65. http://www.ncbi.nlm.nih.gov/pubmed/10697940
17. Lee Y-M, Choi S-M, Park Y-J, Lee S-J, Ku Y, Chung C-P. Tissue Engineered Bone Formation Using Porous Chitosan and Chitosan/Tricalcium Phosphate Matrices. J Korean Acad Periodontol. 1998; 28(4): 577. doi: 10.1902/jop.2000.71.3.410.
18. Jeong Park Y, Moo Lee Y, Nae Park S, Yoon Sheen S, Pyoung Chung C, Lee SJ. Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration. Biomaterials. 2000; 21(2): 153–9. doi: 10.1016/s0142-9612(99)00143-x.
19. Mukherjee DP, Tunkle AS, Roberts RA, Clavenna A, Rogers S, Smith D. An Animal Evaluation of a Paste of Chitosan Glutamate and Hydroxyapatite as a Synthetic Bone Graft Material. J Biomed Mater Res - Part B Appl Biomater. 2003; 67(1): 603–9. doi: 10.1002/jbm.b.10050.
20. Bisen A, Jain AP, Jain S. Formulation and Evaluation of Zidovudine Loaded Microsphere.Asian J. Res. Pharm. Sci. 2013; 3(4):200–5.
21. Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release. 2004; 100(1): 5–28. doi: 10.1016/j.jconrel.2004.08.010.
22. Govender S, Pillay V, Chetty DJ, Essack SY, Dangor CM, Govender T. Optimisation and characterisation of bioadhesive controlled release tetracycline microspheres. Int J Pharm. 2005; 306(1–2): 24–40. doi: 10.1016/j.ijpharm.2005.07.026.
23. Shanmuganathan S, Shanumugasundaram N, Adhirajan N, Ramyaa Lakshmi TS, Babu M. Preparation and characterization of chitosan microspheres for doxycycline delivery. Carbohydr Polym. 2008; 73(2): 201–11. https://doi.org/10.1016/j.carbpol.2007.11.039
24. Peng X, Zhang L, Kennedy JF. Release behavior of microspheres from cross-linked N-methylated chitosan encapsulated ofloxacin. Carbohydr Polym. 2006; 65(3): 288–95. https://doi.org/10.1016/j.carbpol.2006.01.014
25. Ar B, Sevda A, Süheyla H. Natamycin loaded chitosan microspheres for periodontal therapy. Journal of the Faculty of Pharmacy. 2003; 23(2): 77-84
26. Sah AK, Dewangan M, Suresh PK. Potential of chitosan-based carrier for periodontal drug delivery. Colloids Surfaces B Biointerfaces. 2019; 178: 185–98. https://doi.org/10.1016/j.colsurfb.2019.02.044
27. Kumari GD, Raksha G, Deepak K, Anjana G. REVIEW ARTICLE A Review on Chitosan Nanoparticle as a Drug delivery system: Asian J. Pharm. Res. 2020; 10(4): 299-306. doi: 10.5958/2231-5691.2020.00051.9
28. Kong LX, Peng Z, Li SD, Bartold PM. Nanotechnology and its role in the management of periodontal diseases. Periodontol 2000. 2006; 40: 184-96. doi: 10.1111/j.1600-0757.2005.00143.x. PMID: 16398694
29. Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, et al. Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Amlodipine Besylate (AMB ). Asian J. Res. Pharm. Sci. 2017; 7(2): 97-104. doi: 10.5958/2231-5659.2017.00015.7
30. Soskolne WA. Subgingival delivery of therapeutic agents in the treatment of periodontal diseases. Crit Rev Oral Biol Med. 1997; 8(2): 164–74. doi: 10.1177/10454411970080020501.
31. Goudanavar P, Acharya A. Development and Evaluation of In-situ gel containing Linezolid and Diclofenac Sodium in the treatment of Periodontitis. Asian J. Pharm. Tech. 2020; 10(1): 20-26. doi: 10.5958/2231-5713.2020.00005.7
32. Mi FL, Shyu SS, Wu YB, Lee ST, Shyong JY, Huang RN. Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing. Biomaterials. 2001; 22(2): 165-73. doi: 10.1016/s0142-9612(00)00167-8.
33. Lee Y-M, Park Y-J, Lee S-J, Ku Y, Han S-B, Klokkevold PR, et al. The Bone Regenerative Effect of Platelet-Derived Growth Factor-BB Delivered With a Chitosan/Tricalcium Phosphate Sponge Carrier. J Periodontol. 2000; 71(3): 418–24. doi: 10.1902/jop.2000.71.3.418.
34. Lai HL, Abu’Khalil A, Craig DQM. The preparation and characterisation of drug-loaded alginate and chitosan sponges. Int J Pharm. 2003; 251(1–2): 175–81. doi: 10.1016/s0378-5173(02)00590-2.
35. Harish Prashanth K V., Tharanathan RN. Chitin/chitosan: modifications and their unlimited application potential-an overview. Trends Food Sci Technol. 2007; 18(3): 117–31. doi: 10.1016/j.tifs.2006.10.022
36. John J, Emmadi P, Ambalavanan N, Verma E. Comparative Evaluation of Adjunctive Use of Locally Delivered Tetracycline Fiber ( Actisite ) With Scaling and Root Planning in the Treatment of Chronic Periodontitisa Clinical Study. Research Journal of Pharmacy and Technology. 2013; 6(l): 90-95.
37. Barnes CM. Treatment of periodontal disease and the risk of preterm birth. Pract Proced Aesthet Dent. 2007; 19(2): 118. doi: 10.1056/NEJMoa062249.