Author(s): Naveen Kumari K, Srikanth Jeyabalan, Jayaraman Rajangam, N. Gopinathan, S.R. Ramakrishnan, V. Jayashankar reddy

Email(s): srikanth.j@sriramachandra.edu.in

DOI: 10.52711/0974-360X.2023.00965   

Address: Naveen Kumari K1, Srikanth Jeyabalan2*, Jayaraman Rajangam3, N. Gopinathan4, S.R. Ramakrishnan5, V. Jayashankar reddy6
1Research Scholar, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 600116, Tamilnadu, India.
2Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 600116, Tamilnadu, India.
3Principal and Professor, Shri Venkateshwara College of Pharmacy, Ariyur, Pondicherry, India.
4Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dr. M.G.R Educational and Research Institute, Chennai - 600116, Tamilnadu, India.
5Professor/Senior Consultant, Department of Medicine, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai.
6Vice-Principal and Head, Department of Pharmacology, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati - 517506, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 12,     Year - 2023


ABSTRACT:
Alzheimer's disease (AD) is mainly general form of dementia that is linked to the increase of extracellular amyloid beta (Aß) plaques. Oxidative stress and neurotoxicity events that are linked to the aetiology of AD have been postulated to be influenced by genetic, environmental, and dietary variables. Using the use of in vitro models, we attempted to determine whether or not Ulva lactuca had antioxidant and neuroprotective properties. SH-SY5Y The research employed pre-existing Neuroblastoma cell lines. Caspase 3 expression was also determined to know the level of protection of neuronal cells. Our results showed that the total extract of UL effectively reduced cell death and caspase 3 levels were also decreased in the cells treated with TEUL. The extract also has effective antioxidant properties proved. Further, it was also proved that the extract also has acetylcholinesterase enzyme inhibitory activity which is essential in treating AD.


Cite this article:
Naveen Kumari K, Srikanth Jeyabalan, Jayaraman Rajangam, N. Gopinathan, S.R. Ramakrishnan, V. Jayashankar reddy. Neuroprotective Potential of Total Extract of Ulva Lactuca: An In vitro study. Research Journal of Pharmacy and Technology.2023; 16(12):5948-3. doi: 10.52711/0974-360X.2023.00965

Cite(Electronic):
Naveen Kumari K, Srikanth Jeyabalan, Jayaraman Rajangam, N. Gopinathan, S.R. Ramakrishnan, V. Jayashankar reddy. Neuroprotective Potential of Total Extract of Ulva Lactuca: An In vitro study. Research Journal of Pharmacy and Technology.2023; 16(12):5948-3. doi: 10.52711/0974-360X.2023.00965   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-12-66


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