Author(s): Ramu Samineni, Shaik Firoz, Nagaraju Bandaru, Swagat Lenka, P. Pravallika, S. Ooha, Sampath A Gouru, M. Sivakumar

Email(s): samineniramu123@gmail.com , firoz.kallur@gmail.com

DOI: 10.52711/0974-360X.2023.00901   

Address: Ramu Samineni1*, Shaik Firoz2, Nagaraju Bandaru1, Swagat Lenka3, P. Pravallika4, S. Ooha4, Sampath A Gouru5, M. Sivakumar6
1Department of Pharmaceutics, School of Pharmaceutical Sciences, Sandip University, Nashik, Maharashtra 422213.
2Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India - 517127.
3Assistant Professor, Department of Pharmaceutics, Ranchi College of Pharmacy, Chandaghashi, Kutetoli, Ranchi, Jharkhand - 834003.
4Assistant Professor, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India - 517127.
5Senior QA Specialist, ND Global Consulting Services, Texas, USA – 75070.
6Professor and Head, Department of Pharmacognosy, Faculty of Pharmacy, Sree Balaji Medical College and Hospital, BIHER (DU), Chromepet, Chennai - 600044.
*Corresponding Author

Published In:   Volume - 16,      Issue - 12,     Year - 2023


ABSTRACT:
An anti-diabetic drug called Empagliflozin is used to control blood glucose levels in type 2 diabetics. Due to the high rate of hepatic first pass metabolism, it exhibits limited bioavailability. The current study was done to create Mucoadhesive buccal films of Empagliflozin with the aim of increasing bioavailability, patient compliance, and therapeutic efficacy. The solvent casting process used for the preparation of Empagliflozin Mucoadhesive buccal films by using the Mucoadhesive polymers like HPMC K100 and HEC. The prepared films' evaluated for weight variation, thickness, surface pH, uniformity of the drug content, in-vitro residence time, folding durability, in-vitro release, and permeation investigations were all assessed. Formulations (F1-F4) were created by altering the concentrations of various polymers, with F2 and F4 formulations having the highest polymer ratios and the longest-lasting drug release rates. According to characterization results such as in-vitro dissolution experiments, the sustained release formulation F2, F4 shows the best drug release rate, the order of drug release is F1>F3>F2>F4. It was determined that the films could be chosen for the development of buccal films for effective therapeutic applications because they exhibited effective enlargement, a practicable residence duration, and promising controlled drug release.


Cite this article:
Ramu Samineni, Shaik Firoz, Nagaraju Bandaru, Swagat Lenka, P. Pravallika, S. Ooha, Sampath A Gouru, M. Sivakumar. Design and Characterization of Oral Mucoadhesive Buccal Films of Empagliflozin. Research Journal of Pharmacy and Technology. 2023; 16(12):5576-0. doi: 10.52711/0974-360X.2023.00901

Cite(Electronic):
Ramu Samineni, Shaik Firoz, Nagaraju Bandaru, Swagat Lenka, P. Pravallika, S. Ooha, Sampath A Gouru, M. Sivakumar. Design and Characterization of Oral Mucoadhesive Buccal Films of Empagliflozin. Research Journal of Pharmacy and Technology. 2023; 16(12):5576-0. doi: 10.52711/0974-360X.2023.00901   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-12-2


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