Author(s): Ramu Samineni, Shaik Firoz, Nagaraju Bandaru, Swagat Lenka, P. Pravallika, S. Ooha, Sampath A Gouru, M. Sivakumar

Email(s): samineniramu123@gmail.com , firoz.kallur@gmail.com

DOI: 10.52711/0974-360X.2023.00901   

Address: Ramu Samineni1*, Shaik Firoz2, Nagaraju Bandaru1, Swagat Lenka3, P. Pravallika4, S. Ooha4, Sampath A Gouru5, M. Sivakumar6
1Department of Pharmaceutics, School of Pharmaceutical Sciences, Sandip University, Nashik, Maharashtra 422213.
2Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India - 517127.
3Assistant Professor, Department of Pharmaceutics, Ranchi College of Pharmacy, Chandaghashi, Kutetoli, Ranchi, Jharkhand - 834003.
4Assistant Professor, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India - 517127.
5Senior QA Specialist, ND Global Consulting Services, Texas, USA – 75070.
6Professor and Head, Department of Pharmacognosy, Faculty of Pharmacy, Sree Balaji Medical College and Hospital, BIHER (DU), Chromepet, Chennai - 600044.
*Corresponding Author

Published In:   Volume - 16,      Issue - 12,     Year - 2023


ABSTRACT:
An anti-diabetic drug called Empagliflozin is used to control blood glucose levels in type 2 diabetics. Due to the high rate of hepatic first pass metabolism, it exhibits limited bioavailability. The current study was done to create Mucoadhesive buccal films of Empagliflozin with the aim of increasing bioavailability, patient compliance, and therapeutic efficacy. The solvent casting process used for the preparation of Empagliflozin Mucoadhesive buccal films by using the Mucoadhesive polymers like HPMC K100 and HEC. The prepared films' evaluated for weight variation, thickness, surface pH, uniformity of the drug content, in-vitro residence time, folding durability, in-vitro release, and permeation investigations were all assessed. Formulations (F1-F4) were created by altering the concentrations of various polymers, with F2 and F4 formulations having the highest polymer ratios and the longest-lasting drug release rates. According to characterization results such as in-vitro dissolution experiments, the sustained release formulation F2, F4 shows the best drug release rate, the order of drug release is F1>F3>F2>F4. It was determined that the films could be chosen for the development of buccal films for effective therapeutic applications because they exhibited effective enlargement, a practicable residence duration, and promising controlled drug release.


Cite this article:
Ramu Samineni, Shaik Firoz, Nagaraju Bandaru, Swagat Lenka, P. Pravallika, S. Ooha, Sampath A Gouru, M. Sivakumar. Design and Characterization of Oral Mucoadhesive Buccal Films of Empagliflozin. Research Journal of Pharmacy and Technology. 2023; 16(12):5576-0. doi: 10.52711/0974-360X.2023.00901

Cite(Electronic):
Ramu Samineni, Shaik Firoz, Nagaraju Bandaru, Swagat Lenka, P. Pravallika, S. Ooha, Sampath A Gouru, M. Sivakumar. Design and Characterization of Oral Mucoadhesive Buccal Films of Empagliflozin. Research Journal of Pharmacy and Technology. 2023; 16(12):5576-0. doi: 10.52711/0974-360X.2023.00901   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-12-2


REFERENCES:
1.    Shojaei AH, Chang RK, Guo X, Burnside BA, Couch RA. Systemic drug delivery via the buccal mucosa route. Pharm Tech. 2001; 6:70–81. https://www.semanticscholar.org/paper/Systemic-drug-delivery-via-the-buccal-mucosal-route-Shojaei-Chang/b0a8905cbaeb0f35d1770ebf43e550130f8bcdf4
2.    Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs. J Control Release. 2006; 114:15–40. DOI: 10.1016/j.jconrel.2006.04.012
3.    Phalguna Yadagiri, Rama Rao Korapati. Formulation, Characterization and invitro Evaluation of Lamivudine Microspheres. Asian J. Res. Pharm. Sci. 2016; 6(4): 235-239.https://ajpsonline.com/AbstractView.aspx?PID=2016-6-4-5
4.    Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev. 2005; 57:1666–91. DOI: 10.1016/j.addr.2005.07.003
5.    Chetan M Patel, Sejal N Patel, Nikhil P Patel, DM Patel, CN Patel. Formulation and Evaluation of Buccal Adhesive Drug Delivery System of Lercanidipine. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2): 164-168.https://www.rjpdft.com/AbstractView.aspx?PID=2010-2-2-8
6.    NagpalNavneet, Arora Manisha, Rahar Sandeep, Swami Gaurav, Sharma Dinesh, Kapoor Reni. Mucoadhesion Based Solid Dosage Form: The Next Generation. Research J. Pharma. Dosage Forms and Tech. 2010; 2(5): 323-328. https://rjpdft.com/AbstractView.aspx?PID=2010-2-5-2
7.    Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Indian J Pharm Sci. 2008; 70:43–8. DOI: 10.4103/0250-474X.40330
8.    Junginger HE, Hoogstraate JA, Verhoef JC. Recent advances in buccal drug delivery and absorption: in vitro and in vivo studies. J Control Release. 1999; 62:149–59. DOI: 10.1016/s0168-3659(99)00032-2
9.    Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of RasagilineMesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354. https://rjpdft.com/AbstractView.aspx?PID=2013-5-6-8
10.    Samuelov Y, Donbrow M, Friedman M. Sustained release of drugs from ethylcellulose--polyethylene glycol films and kinetics of drug release. J Pharm Sci. 1979; 68:325–9. DOI: 10.1002/jps.2600680318
11.    UbarhandeYB,Regupathy T, Vijaya C, Deshmane SV. Formulation and Evaluation of Mucoadhesive Buccal Films of Losartan Potassium. Research J. Pharm. and Tech. 2009; 2(4): 833-836. https://rjptonline.org/AbstractView.aspx?PID=2009-2-4-108
12.    Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani. Development and Validation of Stability Indicating RP-HPLC Method for Empagliflozin. Asian J. Pharm. Ana. 2016; 6(4): 201-206. DOI: 10.5958/2231-5675.2016.00030.2
13.    Saravanakumar K, Ashok Thulluru, Ramu Samineni, Ishwarya M, PommalaNagaveni, Nawaz Mahammed. Effect of sodium alginate in combination with natural and synthetic polymers on the release of verapamil HCl from its floating microspheres. Journal of Pharmaceutical Sciences and Research. 2019; 11(5): 2028-2035. https://www.openacessjournal.com/abstract/491
14.    Ramu S, Ashok Kumar Y, Srinivasa Rao D, Ramakrishna G. Formulation and evaluation of Valsartan oral dispersible tablets by direct compression method. American Journal of Advanced Drug Delivery. 2014; 2(6): 719-733. https://www.primescholars.com/articles/formulation-and-evaluation-of-valsartan-oral-dispersible-tablets-by-direct-compression-method.pdf
15.    Narahari Narayan Palei, S. Ramu, V. Vijaya, K. Thamizhvanan, Anna Balaji. Green synthesis of silver nanoparticles using leaf extract of Lantana camara and its antimicrobial activity. International Journal of Green Pharmacy. 2020; 14(1): 1-7.DOI: https://doi.org/10.22377/ijgp.v14i02.2878
16.    Ramu S, Suresh P, Srinivasa Rao D, Ramakrishna G. Formulation and evaluation of floating microspheres of Rosiglitazone.International Journal of Pharmaceutical, Chemical and Biological Sciences. 2015; 5(4): 907-918. https://www.ijpcbs.com/abstract/formulation-and-evaluation-of-floating-microspheres-of-rosiglitazone-77544.html
17.    Srinivasa Rao D, Haranadh Reddy S, Ramu S, Rambabu E. Preparation and Evaluation of Mucoadhesive Microspheres of Simvastatin by Ionic Gelation Technique. American Journal of Advanced Drug Delivery. 2014; 2(5): 594-608. https://www.primescholars.com/abstract/preparation-and-evaluation-of-mucoadhesive-microspheres-of-simvastatin-by-ionic-gelation-technique-101830.html
18.    Saravana Kumar K, Ishwarya M, Ramu S. Floating micro spheres: A promising drug delivery. IJPPR. 2017; 11(1):375-388. https://ijppr.humanjournals.com/wp-content/uploads/2018/01/27.M.-Ishwarya-S.-Ramu-K.-Saravana-kumar.pdf
19.    Ramu Samineni, Sumalatha K, Dharani G, Rachana J, Anitha P, Manasa K. Formulation and Evaluation of Oral Disintegrating Tablets of Montelukast Sodium and Desloratidine. Research Journal of Pharmaceutical Dosage Forms and Technology. 2019; 11(3): 152-158. DOI: 10.5958/0975-4377.2019.00026.0
20.    Ramu Samineni, Jithendra Chimakurthy, Sumalatha K, Dharani G, Rachana J, Manasa K, Anitha P. Co-crystals: a review of recent trends in co crystallization of BCS class II drugs. Research Journal of Pharmacy and Technology. 2019; 12(7): 3117-3124. DOI: 10.5958/0974-360X.2019.00527.4
21.    Ramu Samineni, Jithendra Chimakurthy, Sathish Kumar Konidala, VenkateswaraoYamarthy. Development and Validation of Analytical Method for Estimation of Balofloxacin in Bulk and Pharmaceutical Dosage Form by RP-HPLC. Research J. Pharm. and Tech. 2022; 15(7): 2992-2996. DOI: https://doi.org/10.52711/0974-360X.2022.00499
22.    Sathish Kumar Konidala, Ramu Samineni, Yamarthi Venkateswara Rao, Jithendra Chimakurthy, Chaitanya SucharithaKolakaluri, VishaliKorrapati. Novel RP-UPLC Method Development and Validation for Simultaneous Quantification of Emtricitabine, Tenofovir and Efavirenz in Bulk and Tablet Dosage Forms. Research J. Pharm. and Tech. 2022; 15(7): 3141-3146. DOI: https://doi.org/10.52711/0974-360X.2022.00525

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