Author(s):
Daisy Sharma, Manash Pratim Sarma, Chandana Choudhury Barua, Radali Duarah, Pameena Narzary
Email(s):
manash3268@gmail.com
DOI:
10.52711/0974-360X.2023.00916
Address:
Daisy Sharma1, Manash Pratim Sarma2, Chandana Choudhury Barua3, Radali Duarah1, Pameena Narzary1
1Program of Food, Nutrition and Dietetics, Assam Down Town University, Guwahati, Assam.
2Program of Biotechnology, Assam Down Town University, Guwahati, Assam.
3Dept. of Pharmacology and Toxicology, College of Veterinary Science, Khanapara, Guwahati, Assam.
*Corresponding Author
Published In:
Volume - 16,
Issue - 12,
Year - 2023
ABSTRACT:
The present study was performed to determine the antidiabetic activity of Musa balbisiana colla seed, peel, pulp and flower extract. The methanolic extract of Musa balbisiana was evaluated for its inhibition activity on a- amylase and a- glucosidase enzymes. The methanolic seed extract exhibited highest inhibition against a- amylase and a- glucosidase with IC50 values of 121±0.40 and 101±0.53. The effect of Musa balbisiana pulp, seed and flower on fasting blood glucose level in streptozotocin (STZ) induced diabetic rat was studied. On prolong administration of seed extract, it was seen that effectively reduced the blood glucose level and has effective slight increase in body weight. Thus the result indicates that extract of Musa balbisiana colla seed and flower posses potent antidiabetic property.
Cite this article:
Daisy Sharma, Manash Pratim Sarma, Chandana Choudhury Barua, Radali Duarah, Pameena Narzary. In-vivo and In- vitro Antidiabetic potential of Musa balbisiana colla and its different parts. Research Journal of Pharmacy and Technology. 2023; 16(12):5667-0. doi: 10.52711/0974-360X.2023.00916
Cite(Electronic):
Daisy Sharma, Manash Pratim Sarma, Chandana Choudhury Barua, Radali Duarah, Pameena Narzary. In-vivo and In- vitro Antidiabetic potential of Musa balbisiana colla and its different parts. Research Journal of Pharmacy and Technology. 2023; 16(12):5667-0. doi: 10.52711/0974-360X.2023.00916 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-12-17
REFERENCES:
1. Marles, R. J., and Farnsworth, N. R. Antidiabetic plants and their active constituents. Phytomedicine. 1995; 2(2): 137-189. doihttps://doi.org/10.1016/S09447113(11)800590
2. Kumari, S., Katare, P. B., Elancheran, R., Nizami, H. L., Paramesha, B., Arava, S. and Banerjee, S. K. Musa balbisiana fruit rich in polyphenols attenuates isoproterenol-induced cardiac hypertrophy in rats via inhibition of inflammation and oxidative stress. Oxidative Medicine and Cellular Longevity. 2020. doi.https://doi.org/10.1155/2020/7147498
3. Rafa Zubair, N. V., Suresh, A., Babu, G., Asma, M. A., Prahlad, A., and Hanisha, K. P.Assessment of anti-ulcer potential of unripe fruit extract of Musa balbisiana in stress induced ulcer model. World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7(8): 1328-1336.doi.10.20959/wjpps20188-12181
4. Ara, F., Tripathy, A., and Ghosh, D. Possible Antidiabetic and Antioxidative Activity of Hydro-Methanolic Extract of Musa balbisiana (Colla) Flower in Streptozotocin-Induced Diabetic Male Albino Wistar Strain Rat: A Genomic Approach. Assay and Drug Development Technologies. 2019; 17(2): 68-76 doi..https://doi.org/10.1089/adt.2018.889
5. Gopalan, G., Prabha, B., Joe, A., Reshmitha, T. R., Sherin, D. R., Abraham, B., and Nisha, P. Screening of Musa balbisianaColla. seeds for antidiabetic properties and isolation of apiforol, a potential lead, with antidiabetic activity. Journal of the Science of Food and Agriculture. 2019: 99(5): 2521-2529. doi.https://doi.org/10.1002/jsfa.9462
6. Borah, M., and Das, S. Antidiabetic, antihyperlipidemic, and antioxidant activities of Musa balbisiana Colla. in Type 1 diabetic rats. Indian Journal of Pharmacology. 2017; 49(1): 71. doi http://doi.org/10.4103/0253-7613.201030
7. Punithavathi, V. R., Prince, P. S. M., Kumar, R., and Selvakumari, J. Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats. European Journal of Pharmacology. 2011; 650(1): 465-471 doi..https://doi.org/10.1016/j.ejphar.2010.08.059
8. Kalita, H., Boruah, D. C., Deori, M., Hazarika, A., Sarma, R., Kumari, S. and Devi, R. Antidiabetic and antilipidemic effect of Musa balbisiana root extract: A potent agent for glucose homeostasis in streptozotocin-induced diabetic rat. Frontiers in Pharmacology. 2016; 7: 102 doi..https://doi.org/10.3389/fphar.2016.00102
9. Tadera, K., Minami, Y., Takamatsu, K., and Matsuoka, T. Inhibition of α-glucosidase and α-amylase by flavonoids. Journal of Nutritional Science and Vitaminology. 2006; 52(2): 149-153. doi.https://doi.org/10.3177/jnsv.52.149
10. Sabu, M. C., and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. Journal of Ethnopharmacology. 2002; 81(2): 155-160. doi.https://doi.org/10.1016/S0378-8741(02)00034-X
11. Ahamad, J., and Naquvi, K. J. Review on role of natural Αlpha-Glucosidase inhibitors for Management of Diabetes Mellitus. Int J Biomed Res. 2011; 2: 374-80.www.ssjournals.com
12. Agarwal, P., and Gupta, R. Alpha-amylase inhibition can treat diabetes mellitus. Res. Rev. J. Med. Health Sci, 2016; 5(4): 1-8.
13. Mai, T. T., and Chuyen, N. V. Anti-hyperglycemic activity of an aqueous extract from flower buds of Cleistocalyxoperculatus (Roxb.) Merr and Perry. Bioscience, Biotechnology, and Biochemistry. 2007; 71(1): 69-76. doi.https://doi.org/10.1271/bbb.60373
14. Wongsa, P., Chaiwarit, J., and Zamaludien, A. In vitro screening of phenolic compounds, potential inhibition against α-amylase and α-glucosidase of culinary herbs in Thailand. Food Chemistry. 2012; 131(3): 964-971 doi.https://doi.org/10.1016/j.foodchem.2011.09.088
15. T. Sundarrajan, V. Velmurugan, R.Srimathi. Phytochemical Evaluation and In Vitro Antidiabetic Activity of Ethanolic extract of Alternanthera ficodia Linn. Research J. Pharm. and Tech. 2017; 10(9): 2981-2983.
16. SLDV Ramana Murty Kadali, Magala Charan Das, MHRK Gupatha Bayya, Vijay Kumar M. Preliminary Phytochemical Screening and Evaluation of effect of aqueous and Ethanolic leaf extracts of Chloroxylon swietenia on blood glucose in Streptozotocin Induced Diabetic rats. Research J. Pharm. and Tech. 2019; 12(11):5495-5500.
17. .AlimuddinSaifi, Rajani Chauhan, Jaya Dwivedi. Development of a polyherbal formulation FMST and evaluation for antidiabetic activity in alloxan induced diabetic rats. Asian J. Pharm. Res. 2017; 7(1): 1-7.
18. Sherin A. Hameed, JoyammaVarkey, P. Jayasekhar. Schiff bases and Bicyclic derivatives comprising 1, 3, 4-thiadiazole moiety- A Review on their Pharmacological activities. Asian J. Pharm. Res. 2019; 9(4):299-306.
19. Sravan Prasad Macharla, Venkateshwarlu Goli, Ravinder Nath A. Antidiabetic Activity of Bambusaarundinaceae Root Extracts on Alloxan Induced Diabetic Rats. Asian J. Res. Pharm. Sci. 2012; 2(2):73-75.
20. P. B. Suruse, M. K. Kale, N. J. Duragkar, A. Gundawar. Formulation and Evaluation of Antidiabetic Herbal Capsules. Research J. Pharma. Dosage Forms and Tech. 2011; 4(2): 113-118.
21. Mayank Panchal, Biren Shah, Krishna Murti, Megha Shah. Phytochemical investigation and antidiabetic activity studies of Moringa oliefera roots. Research J. Pharmacology and Pharmacodynamics. 2011; 3(5): 268-277
22. Alimuddin Saifi, Rajani Chauhan, Jaya Dwivedi. Assessment of the antidiabetic activity of Syzygiumcumini (Linn.) Skeels in alloxan induced diabetic rats. Res. J. Pharmacology and Pharmacodynamics. 2016; 8(3): 91-96
23. Godavari A, Amutha K. In vitro Antidiabetic Activity of Garcinia mangostana by Enzymatic Inhibition Assay. Research J. Pharm. and Tech. 2017; 10(2): 508-512.
24. Vidyasabbani, RameshAlluri, ShobharaniSatla. Comparative In vitro antidiabetic and antioxidant activity of Pulicariawightinia, Curcuma inodora ,Derris scandens leaf extracts. Research J. Pharm. and Tech. 2017; 10(6): 1615-1620.